Discover and read the best of Twitter Threads about #Aging
Most recents (24)
Outcomes after Critical Illness: @NEJM
Cardiac critical care and CCM often overlap
Here are few point summary
👇👇👇
Cardiac critical care and CCM often overlap
Here are few point summary
👇👇👇
1/ 🚑 Critical care has seen major advancements, but post-critical illness complications are prevalent & can persist for years. Health inequities can worsen outcomes. Covid-19 pandemic has highlighted this issue.
2/ 🌐 A continuum of care from ICU to community is needed, alongside basic science inquiry to understand multiple mechanisms of morbidity. Transparent reporting of long-term ICU outcomes is essential.
Muscle growth occurs when muscle protein synthesis exceeds muscle protein breakdown. Resistance exercise stimulates both muscle protein synthesis and breakdown. Ingestion of protein further increases muscle protein synthesis and is needed to achieve positive protein net balance.
In young adults, 20 g of high-quality protein seems optimal to stimulate post-exercise muscle protein synthesis. However, is this also true for older adults?
3/
3/
1/5 Fascinating work from Jae-Hyun Yang and colleagues on #mammalian #aging, published in Cell...
An abstract thread 🧵...
"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."
cell.com/cell/fulltext/…
An abstract thread 🧵...
"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."
cell.com/cell/fulltext/…
2/5 "In #yeast, #epigenetic information is lost over time due to the relocalization of #chromatin-modifying proteins to #DNA breaks, causing cells to lose their identity, a hallmark of yeast #aging."
3/5 "Using a system called “#ICE” (#inducible changes to the #epigenome), we find that the act of faithful #DNA #repair advances aging at #physiological, #cognitive, and #molecular #levels, including #erosion of the #epigenetic #landscape,..."
The findings of this one support the hypothesis of a compensatory upregulation of autophagy in the setting of deterioration of tissue composition and muscle dysfunction, as seen in ageing.
- "In contrast to what has been observed in preclinical models... in our study, the protein content of the lysosomal mediators TFEB, vATPase, and LAMP1 was not different between age groups".
- "Therefore, upregulation of upstream autophagy and mitophagy proteins in muscle of older adults not accompanied by increased expression of lysosomal markers may indicate greater autophagic signaling with no actual disposal of damaged mitochondria."
Our immune system is essential in keeping us healthy.
But the immune system also changes profoundly as we age.
Why is that? Could we prevent it?
Let's see how #singlecell biology can help us better understand #immune #aging
🧵👇
But the immune system also changes profoundly as we age.
Why is that? Could we prevent it?
Let's see how #singlecell biology can help us better understand #immune #aging
🧵👇
First, some background.
Everybody knows that the immune system is hugely complex.
#singlecell sequencing has (arguably) done more for the immune system than for other health applications.
Via #scRNAseq, we discovered & characterized crazily detailed immune cell phenotypes.
Everybody knows that the immune system is hugely complex.
#singlecell sequencing has (arguably) done more for the immune system than for other health applications.
Via #scRNAseq, we discovered & characterized crazily detailed immune cell phenotypes.
Such detailed phenotypes have been found in both healthy and diseased tissues.
I wrote several threads about this topic and find it to be one of the most foundational & fascinating progresses that have happened in biomedicine in the past 10 years.
I wrote several threads about this topic and find it to be one of the most foundational & fascinating progresses that have happened in biomedicine in the past 10 years.
This one found that Sicilian long-lived individuals have changes in circulatory fatty acids status with advancing age, characterized by a reduction in blood levels of total PUFA and trans FA with age, whereas total SFA remained unchanged throughout life.
- This fatty acid profle characterized by high MUFA content may indicate reduced peroxidation while maintaining membrane fluidity.
- "We suppose that the high consumption of the extra virgin olive oil (EVOO) may have infuenced this datum"
In this one, the addition of protein in a resistance training program was more effective than the program alone in increasing skeletal muscle mass and strength in older adults, and was also associated with less declines in skeletal muscle mass and strength after cessation.
- The PRO supplement beverage contained 160 kcal of energy, 11.0 g of protein, 2.2 g of fat, 24.0 g of carbohydrate, and 2,300 mg of leucine per serving.
Participants in the RT+PRO group ingested the protein supplement within 5 min after completion of the RT program.
This one suggests that age acceleration is associated with lower strength and/or loss of strength over time in US adults aged 51 years and older, followed over an 8-10 year period.
- "A growth in research evidence documents that epigenetic phenomena, such as DNA methylation (DNAm), are highly implicated in the development of disease and rate of biological ageing...
Ref:
doi.org/10.1186/s13059…
Ref:
doi.org/10.1186/s13059…
"...Given that methylation profiles are thought to be modifiable by lifestyle and other environmental factors, it has been proposed that DNAm age is a robust biological ageing clock providing a superior estimate of true biological age over chronological age...
I'm absolutely delighted to share my newest review on how the #GutMicrobiota influences adult hippocampal #Neurogenesis! @jfcryan @oliviafoleary @Pharmabiotic @BPL_Journal
Our figure👇 shows key pathways by which #GutMicrobiota is known to influence AHN.
content.iospress.com/articles/brain…
Our figure👇 shows key pathways by which #GutMicrobiota is known to influence AHN.
content.iospress.com/articles/brain…
@jfcryan @oliviafoleary @Pharmabiotic @BPL_Journal 2/5 #Neurogenesis (the birth, development, integration, and survival of neurons) in the #hippocampus regulates learning, memory, and mood, but is disrupted by lifestyle factors & diseases, including unhealthy diet, #aging, #stress, #AlzheimerDisease & in 🐭models of #Depression
3/5 (It is hard to measure hippocampal neurogenesis in human tissue, so most of our evidence relies on preclinical studies, along with mixed evidence in post-mortem tissue.
Below's figure outlines some common techniques for measuring neurogenesis)
Below's figure outlines some common techniques for measuring neurogenesis)
An Israeli biotech company, Renewal Bio that recently created mouse embryos using stem cells, has announced plans to make human embryos to harvest tissue for organ transplants and anti-aging procedures.
#Stemcells #biotech #biology #Syntheticbiology #Aging #transplant
#Stemcells #biotech #biology #Syntheticbiology #Aging #transplant
The scientist behind the work clarified that:
The synthetic embryos were not "real" embryos and did not have the potential to develop into live animals. But that is partly because they don't have the technology, right now, to do so.
The synthetic embryos were not "real" embryos and did not have the potential to develop into live animals. But that is partly because they don't have the technology, right now, to do so.
He admits to taking his "ground-breaking" technology to the next level and creating human embryos. The purpose is to harvest tissue to be used in transplant treatments meant to lengthen a person's life and health.
How wounds heal
#woundhealing #injury #homeostasis #angiogenesis #epidermal #skin #MedTwitter #meded #foamed #InnoMed
#woundhealing #injury #homeostasis #angiogenesis #epidermal #skin #MedTwitter #meded #foamed #InnoMed
Timelapse Of A Wound Healing
#epidermal #medtwitter #meded #foamed #InnoMed #homeostasis #injuy #woundhealing #sciencetwitter
#epidermal #medtwitter #meded #foamed #InnoMed #homeostasis #injuy #woundhealing #sciencetwitter
How does #aging affect #WoundHealing?
#scRNAseq identifies major changes in cell compositions, kinetics, and molecular profiles during #woundhealing in aged #skin @CellReports
bit.ly/3PZMies
#epidermal #MedTwitter #meded #foamed #InnoMed #bioinformatics #homeostasis
#scRNAseq identifies major changes in cell compositions, kinetics, and molecular profiles during #woundhealing in aged #skin @CellReports
bit.ly/3PZMies
#epidermal #MedTwitter #meded #foamed #InnoMed #bioinformatics #homeostasis
Using data from 3095 people living in Sweden, this one identified the most relevant predictors of 18-year mortality in individuals aged ≥60 years.
- Individuals’ social connections and civil status were identified as meaningful predictors of mortality, as well as socio-environmental characteristics such as living conditions, civil status, and leisure activities.
- Physical function also had a strong prognostic role, as the functional status domain, encompassing several measures of physical performance and dependency, was the only single domain that showed comparable predictive performance to chronological age.
This systematic review comes to the conclusion that physical activity with regular aerobic training of moderate to vigorous intensity appears to help preserve leukocyte telomere length, a biomarker of biological aging associated with several age-related diseases.
* Key points:
- As life-expectancy increases, lifestyle choices like exercise take on increasing importance in healthy aging.
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures & accreditation statement are at ckd-ce.com/disclosures/. FOLLOW US!
I was recently in Switzerland, mostly around Berne. Since there are municipal elections in #Ontario, I thought that it would be nice to talk more about quality of life beyond lower taxes. #onpoli #topoli 1/14
They come from government, the non-profit and private sectors. They may not all be applicable - of course. Thanks for the inspiration @shawnmicallef #switzerland 2/14
On Saturdays in August, all #museums in Berne were free. @museenbern museen-bern.ch/en/specials/fr… 3/14
El ejercicio como mimético del envejecimiento
#hormesis #aging #Hilo 🧵🧵🧵👇
👉La respuesta al ejercicio es la misma que "envejecer"😱De hecho, el ejercicio "puntual" podría conceptualizarse como un episodio transitorio d "envejecimiento" #Seguimos 🧐👇
doi.org/10.3389/fphys.…
#hormesis #aging #Hilo 🧵🧵🧵👇
👉La respuesta al ejercicio es la misma que "envejecer"😱De hecho, el ejercicio "puntual" podría conceptualizarse como un episodio transitorio d "envejecimiento" #Seguimos 🧐👇
doi.org/10.3389/fphys.…
🟢Estamos hablando de una dosis hormética de ejercicio, es decir, exponerse a un factor estresante, en una dosis puntual, de tal forma que pueda crearse una adaptación... 🤔Uhm.. digamos, un "envejecimiento temporal".
Lo vemos en una gráfica abajo 🧐👇
Lo vemos en una gráfica abajo 🧐👇
El cuerpo se somete a un esfuerzo puntual😥(pico-A) La inflamación, los efectos en el sistema cardiovascular, el estrés oxidativo, etc... inducidos por el ejercicio se atenúan después del entrenamiento creando adaptaciones a este "envejecimiento puntual" (valle-B) #Seguimos👇
Efecto del Ejercicio sobre el Estrés Oxidativo y la Inflamación en el Envejecimiento Muscular y Vascular
👉El ejercicio mejora las funciones musculares y vasculares favoreciendo el envejecimiento saludable
#Hilo🧵👇
#ROS #músculo #ECV #aging #mioquinas
doi.org/10.3390/ijms23…
👉El ejercicio mejora las funciones musculares y vasculares favoreciendo el envejecimiento saludable
#Hilo🧵👇
#ROS #músculo #ECV #aging #mioquinas
doi.org/10.3390/ijms23…
🔴El daño oxidativo⚡️ asociado con el envejecimiento y la inflamación crónica🎈 que ocurre a nivel celular y de los tejidos, forman un trasfondo que promueve la disfuncionalidad del sistema cardiovascular y el músculo. 👇#ROS
✅En el musculo, el ejercicio regula: La proteostasis (más síntesis y menos degradación de proteínas), aumenta la biogénesis mitocondrial, reduce el daño oxidativo, disminuye la inflamación crónica y mejora el perfil de mioquinas, favoreciendo la estructura y la función muscular
This study tried to determine the molecular changes with ageing in tendons in humans (specifically, at the level of tendon protein synthesis and gene expression changes), as well as the subsequent impacts of 4 and 8 weeks of training.
- Changes in remodelling with exercise appeared to occur early in tendon (with few changes seen with 8 weeks of training).
- While it appeared that the older tendon was less responsive to exercise training, in terms of a molecular remodelling perspective, protein synthesis was similar for both age groups.
This one in individuals ≥65 years living in Germany found that compared to physically inactive individuals, those being physically active are less likely to utilize long-term care.
- Compared to physically inactive individuals, those being physically active were less likely to utilize long-term care.
- The combination of walking and exercise showed the strongest association with non-utilization of long-term care in the entire cohort and in males.
This Mendelian randomization study provides evidence that genetically predicted walking may reduced the risk of Alzheimer’s disease.
- Genetically predicted higher levels of walking were found to decrease the risk of AD.
- Interestingly, the study failed to find any associations between genetically predicted overall activity, sedentary behavior, and moderate-intensity activity with AD.
This systematic review and meta-analysis of randomized controlled trials finds that resistance training exercise may promote increases in bioelectrical phase angle, an indicator of body cell mass and cellular health, in older adults.
- Phase angle is an indicator of body cell mass and cellular health, that is also moderately associated with muscle quality.
- Resistance training programs lasting ≥ 8 weeks were found to result in phase angle increases in participants aged ≥ 60 years.
1/15 I interview antiaging expert Aubrey de Grey. He has been interviewed by Joe Rogan and 60 minutes. He corrects mistaken views on aging and talks big new developments. significant human life extension by 2035 #aging #antiaging #Future youtube.com/embed/xWAIb1Mv…
2/15 Next Level Funding has been reached for Antiaging has been reached. Over $12B+ invested. Billions from Jeff Bezos and Saudi Hevolution fund. Progress is not money limited.
youtube.com/embed/xWAIb1Mv…
youtube.com/embed/xWAIb1Mv…
3/15 Antiaging expert Aubrey de Grey talks new trends and big new antiaging developments
youtube.com/embed/xWAIb1Mv…
youtube.com/embed/xWAIb1Mv…
Interested in 2nd a2PilotAwards.ai for projects at the intersection of #AI and #healthyaging?
Register for our July 14 webinar and Q&A with @JH_AITC, @pennaitech, and #MassAITC:
a2PilotAwards.ai/webinar
#agetech #ADRD #aging #longevity #healthtech #digitalhealth
Register for our July 14 webinar and Q&A with @JH_AITC, @pennaitech, and #MassAITC:
a2PilotAwards.ai/webinar
#agetech #ADRD #aging #longevity #healthtech #digitalhealth
Using metabolomics, this one identified associations between 13 metabolites and future risk of all-cause mortality, suggesting that the risk of all-cause mortality is linked to alternations in metabolism earlier in life.
- Circulating levels of 13 metabolites were associated with future risk of all-cause mortality.
- These associations were replicable in two independent cohorts, comprising over 5,000 individuals with different baseline ages, sex distributions, and follow-up times.
