Kai Kupferschmidt Profile picture
Sep 28, 2020 10 tweets 12 min read Read on X
“Last week we reached an important milestone in which, @WHO issued the first Emergency Use Listing for a quality antigen based rapid diagnostic test, and we expect other rapid tests to follow. ”, says @DrTedros at #covid19 presser.
@WHO @DrTedros Good news: 120 million of these tests will be made available to low- and middle-income countries, to "enable the expansion of testing, particularly in hard to reach areas that do not have lab facilities or enough trained health workers to carry out PCR tests”, says @DrTedros.
@WHO @DrTedros These tests are cheaper ("priced at a maximum of 5 US dollars per unit”) and faster (15-30 minutes) than PCR, says @DrTedros. "The quicker #COVID19 can be diagnosed, the quicker action can be taken to treat and isolate those with a virus and trace their contacts."
@WHO @DrTedros (Side note: @DrTedros also gave a shout-out to @c_drosten’s lab in his opening remarks. "Working with our partner lab in Germany, Charité University, we published the first instructions on how to build a validated #COVID19 PCR test.")
@WHO @DrTedros @c_drosten “This is a big step towards more equitable allocation of diagnostics”, says @PeterASands. "Right now, high income countries are conducting 292 tests per day, per 100,000 people”
upper middle-income countries: 77
lower middle-income countries: 61
low-income countries: 14
@WHO @DrTedros @c_drosten @PeterASands "They're not a silver bullet”, says @PeterASands of rapid diagnostic tests, "but hugely valuable as a complement to PCR tests, since although they're a bit less accurate, they're much faster, cheaper, and don't require a lab."
@WHO @DrTedros @c_drosten @PeterASands Just over 50 million tests conducted in Africa, says @JNkengasong. “not because the continent doesn't know how to test. It's essentially because the current tools that we have, do not enable us to fulfil those four criteria that is easy to use, affordable, scalable and reliable."
@WHO @DrTedros @c_drosten @PeterASands @JNkengasong Volume guarantee agreements have been signed between Gates Foundation and two rapid diagnostic test producers (Abbott and SD Biosensors) "to make 120 million tests available at $5 dollars for low, middle income countries over a period of six months”, says @BoehmeCatharina.
@WHO @DrTedros @c_drosten @PeterASands @JNkengasong @BoehmeCatharina Three areas in particular where rapid tests will be helpful, says @mvankerkhove:
1. "respond to suspected outbreaks in remote settings or institutions or semi-closed communities where we don't have access to PCR”
2. speedy cluster investigations
3. monitor high-risk populations
@WHO @DrTedros @c_drosten @PeterASands @JNkengasong @BoehmeCatharina @mvankerkhove Q about deaths being wrongly attributed to #covid19
“When you count anything, you never count it perfectly, but I can assure you that the current numbers are likely an underestimate of the true toll of COVID”, says @DrMikeRyan

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More from @kakape

Jun 20
One question at the heart of the #h5n1 outbreak in US cows has been: Is there something special about this virus? Or is H5N1 generally able to do this and this particular version was just "in the right place at the right time"?
Quick thread, because it seems we have an answer
Researchers in Germany have done an experiment in a high-security lab infecting cows directly with the strain of #H5N1 circulating in cows in the US (B3.13) and infecting others with an #h5n1 strain from a wild bird in Germany.
(I wrote about the plans here: )science.org/content/articl…
In both cases they infected the udders directly through the teats and in both cases the animals got sick. They "showed clear signs of disease such as a sharp drop in milk production, changes in milk consistency and fever." That suggests there is nothing special about B3.13.
Read 8 tweets
Jun 13
The thing that I find most frustrating about the entire mpox/gain-of-function debate is how the uncertainties that lie at the base of it all just become cemented as certainties that are then carried forward.
(If you know anything about me you know I love me some uncertainty...)
Most importantly: The interim report on the investigation into these experiments released on Tuesday numerous times calls clade II "more transmissible" or even "much more transmissible".
But that is a claim that has very little evidence at all.
In fact you can find plenty of literature that argue the exact opposite, that in fact clade I is more transmissible.
Just, as an example, here is Texas HHS:
"Clade I MPXV, which may be more transmissible and cause more severe infection than Clade II..."
dshs.texas.gov/news-alerts/he…
Read 7 tweets
May 30
Some more details on the latest (3rd) human case of #H5N1 #avianflu linked to the current outbreak in dairy cows:
- second case in Michigan but not linked to the other case (different farm)
- reported cough and eye discomfort with watery discharge
- given oseltamivir, isolating at home
"As with the previous two cases (one in Texas, one in Michigan), the person is a dairy farm worker with exposure to infected cows, making this another instance of probable cow-to-person spread."
"The patient reported upper respiratory tract symptoms including cough without fever, and eye discomfort with watery discharge.  The patient was given antiviral treatment with oseltamivir, is isolating at home, and their symptoms are resolving."
Read 5 tweets
May 16
A thought on communication:
In today’s presser's opening statement @USDA presented work on killing H5N1 in ground beef through cooking. They mentioned no virus being present at 160°F and 145°F. Only later when someone asked, they mentioned that at 120°F there was some virus left.
@USDA I have thought a lot about trust and transparency in the wake of the #covid19 pandemic and to me this seems exactly the kind of communication style that does not build trust.
Yet another lesson not learnt in my book...
@USDA For reference, my thread on this:
Read 4 tweets
May 16
Researchers at @USDA have done a “ground beef cooking study” to test at what temperature #H5N1 in meat is killed. To be clear: Tests have found no H5N1 in beef samples, so this was done “in the interest of scientific inquiry and to further reaffirm consumer confidence”
@USDA So researchers added #H5N1 to ground beef patties then cooked them:
“There was no virus present in the burgers cooked to 145° [Fahrhenheit] internal temperature, or roughly medium, or 160°, which equates with a well done burger, which is the recommended cooking temperature”
@USDA At lower temperatures, some virus survived. "Cooking to I believe it was 120° [Fahrenheit] did show that there was virus still in the cooked hamburger patty, although at much, much reduced levels."
(But remember that these were experimentally infected burgers.)
Read 4 tweets
May 16
#h5n1 presser by @USDA and @HHSGov just ended. Had some some interesting bits (but what I would really love to see is still... serology):
@USDA @HHSGov - USDA researchers have done a “ground beef cooking study” to test at what temperature #H5N1 in meat is killed. To be clear: Tests have found no H5N1 in beef samples, so this was done “in the interest of scientific inquiry and to further reaffirm consumer confidence”
@USDA @HHSGov So the researchers added H5N1 to ground beef patties then cooked them. “There was no virus present in the burgers cooked to 145 degrees internal temperature, or roughly medium, or 160 degrees, which equates with a well done burger, which is the recommended cooking temperature”
Read 9 tweets

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