Some persons, through absolutely no fault of their own, present with metastatic disease.
In some persons, through absolutely no fault of their own, breast cancer comes back in another part of their body. #bcsm#bcam /2
Persons with zero risk factors are diagnosed with the disease. It does not matter if you do not have a family history. It does not matter if you faithfully do your mammogram (mammos detect early, they don’t prevent). #bcsm#bcam /3
Breast cancer can come back.
Even after all the “right” treatment.
Even with the best doctors.
Even if you remove both breasts.
B/c it can come back in other parts of the body.
When breast cancer spreads to the lungs/bone/liver/brain—it is still breast cancer. #bcsm#bcam /4
And this “it can come back”—we call that all sorts of things: recurrence, stage 4, metastatic, advanced breast cancer.
But often it simply goes unsaid. That ugly, scary risk.
I know-that data is 20 years old! In the last 20 years there have been amazing advances breast cancer treatment—hopefully the 20 year historical curves for women diagnosed in 2020 are better. #bcsm#bcam /8 (Breast cancer: 45 years of research & progress fal.cn/37KOd )
But I want everyone to know & understand that not everyone feels very pink this month.
Some are mourning the loss of a cherished loved one to a terrible cancer.
Some are living with a diagnosis that will someday take their life.
Each individual can have their own experience with breast cancer.
And we can hold space for that.
We can even hold un-pink, uncomfortable, hard ugly space for that.
T2
KAITLIN randomized patients after adriacymycin/cyclophosphamide to either paclitaxel/trastuzumab/pertuzumab or TDM-1/pertuzumab. #bcsm
The two arms were nearly identical for primary endpoint IDFS, subsequently a “ negative “ trial. This trial raises all sorts of questions and controversies. Based on TRAIN-2, the administration of anthracycline to all patients likely could have been avoided #bcsm
Additionally, we have little data about the specific benefits of adding pertuzumab to TDM-1. #bcsm
America,
In WW1, America lost 116,516 people, with over half (63,114) of those deaths attributed to influenza/disease rather than combat. I know these figures because #KansasCity is home to the remarkable the National WW1 museum. You should visit when this is all over.
Thread/1
But as I watch the numbers unfold and read the predictions, I can’t help but wonder—where will the international COVID19 memorial be located? New York? They already currently have 1552 #COVID19 deaths.
On September 11 there were 2,997 victims /2
There were indications that use of any antioxidant supplement (vitamins A, C, and E; carotenoids; coenzyme Q10) both before and during treatment was associated with an increased hazard of recurrence (adjusted hazard ratio [adjHR], 1.41; 95% CI, 0.98 to 2.04; P = .06) /2
Relationships with individual antioxidants were weaker perhaps because of small numbers. For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; P < .01)... /3
Dr. Marks says radiation (XRT) technique allows for both better treatment planning for treating disease area and to minimize collateral damage (heart, lung) #SABCS19