An estimated 750M, 10% of world’s population have been infected by Covid-19, says WHO's Dr M Ryan

This implies far lower Infection Fatality Rate than previously claimed & potentially significant implications for many countries.

Analysis:

[5Oct2020_1]

irishtimes.com/news/ireland/i…
While clearly this is only a "best guess" figure, we can still conduct a rough analysis, leading to an interesting conclusion.

10% of world population ~ 750M
Covid-19 deaths to date ~ 1M
Implied IFR = 1/750 = ~ 0.13%
(IFR = Infection Fatality Rate)
An IFR of ~0.13% is almost an order of magnitude lower than the ~1% values seen in much of the predictive modelling that has been used to guide policy, lockdown decisions etc. (E.g. ICL used 0.9% for UK in March).

Even for a rough estimate, this is a significant difference.
An order of magnitude reduction in IFR implies a similar reduction in predicted fatalities

For, e.g, UK & others, this means 10's rather than 100's of thousands of deaths.

ICL predicted several hundred thousand UK deaths in the "do nothing" scenario.

This did not happen.
UK total covid-19 fatalities to date are ~42k; indeed 10's & not 100's of thousands.

The same appears generally to be true for the higher fatality locations. Fatalities have been approximately an order of magnitude lower than predicted.
Responsible & fair to re-remind ourselves that the WHO surely meant this number as a rough estimate. However an order of magnitude difference is very large in this situation & adjusting that "10% infected" figure up or down somewhat would make little difference to the results.
Even more interesting is the potential implication of this for today & the future, especially for those locations that have already experience high fatalities (eg. UK)

Many in these locations believe that, unless strict measures are maintained, huge numbers of deaths will occur.
However, the WHO's own implied IFR & it's consequences would seem to support the hypothesis that, while further infections & deaths in these locations are possible (as with many viruses), in terms of the bigger picture the epidemic may well have largely run its course.
[Analysis, opinions and errors my own.]

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More from @RuminatorDan

26 Sep
ANALYSIS OF SARS-CoV-2 GROWTH ILLUSTRATION PRESENTED AT VALLANCE-WHITTY DOWNING STREET BRIEFING ON 21 SEP 2020

Implied CFR appears to be >50% lower than IFR used by ICL in March, suggesting new cases in red area would lead to ~2,000 deaths (~5% of spring total).

[26 Sep 2020v1] Image
The red area would contain a total of ~500,000 new cases.

How many deaths would be expected to occur as a result?

PV commented that, by mid October, there might be 50,000 new cases per day & that this would be expected to lead, a month or so later, to 200 plus deaths per day.
This implies a Case Fatality Rate of approx:
CFR = 200 / 50,000 = ~ 0.4%.

Since not all infections are detected, the Infection Fatality Rate (IFR) will be lower still.

This ~0.4% CFR is, however, in itself 50%+ lower than the 0.9% IFR used in ICL’s March paper & modelling.
Read 6 tweets
24 Sep
SEP 2020 CORONAVIRUS CASES INCREASES
IN UK, FRANCE, ITALY, SPAIN
APPEAR DIFFERENT FROM SPRING

The UK, along with other European countries, is experiencing a rise in SARS-CoV-2 cases.

[24 September 2020, v1.1]
[Analysis, opinions & errors my own.]
Many think this to be a similar situation to that experienced in the spring. However, there are also reasons to suspect that this might not be the case.

Here, an analysis using testing, cases and deaths data:
TESTING:

Testing has increased enormously. In spring mainly the ill were tested & the quantity of tests was far lower. In terms of true numbers of infections, we were only detecting the tip of the iceberg. Today, we conduct mass testing of the healthy.
Read 14 tweets
23 Sep
Faucci & recent UK comments disagree with recent evidence re low HE threshold/pre existing immunity etc. However, even without knowing the underlying mechanism, the observed reality (data) strongly suggests it. Sweden, e.g., is prime evidence. Note also how those locations 1/4
in which the virus appears to have run its course have fairly similar outcomes. The differences between fatalities in these locations are small compared to the fact that they are all about a tenth of what was predicted. This is meaningful information. 2/4
If the "high fatality & all susceptible & lockdowns worked" scenario was true for these locations, one would expect more variance between them than we see, because outcomes would be highly sensitive to the measures taken & their timing (as Neil F himself has, I believe said) 3/4
Read 4 tweets
15 Sep
Glanced through it so apols to all concerned for any misintetptetation on my part. Many points there so will comment on just 2.
1) Gompertz: Agree & disagree. The death curves for most locations are gompertz-like but not 'perfect' Gompertz, due, for example to effects of 1/n
2/n. time lag to death, which kinks that now-famous near-linear log(daily/cumulative) deaths plot. Happy to discuss that with any of the technical guys. I think the key point with Gompertz though is that what we have here appears to act as a natural process - which it does.
...
3/n 2) Sweden: here's some work I did looking at the UK & Sweden. Please understand it though. The fact that Sweden and UK both have near identical deaths isn't as interesting as the fact that they don't have very different deaths.
...
Read 8 tweets
27 Aug
SWEDEN & UNITED KINGDOM, SARS-CoV-2
AN ANALYSIS & DISCUSSION (v1.1):

Despite claims to the contrary the data are clear:
The outcomes for both countries have been remarkably similar.
This has happened in spite of the very different approaches taken.
Several people suspected months ago (I began in March) that, although SARS-CoV-2 was serious, the overall damage was probably overestimated. This post from May forecasts similar outcomes to what we now see.
Yet the narrative says Sweden has "failed". It is true that everyone made mistakes, e.g. care homes, & there have been differences between Sweden & other Scandinavian countries.

However the overall outcome, as shown above, speaks for itself. Sweden & UK are very similar.
Read 12 tweets
26 Aug
SWEDEN & UNITED KINGDOM, SARS-CoV-2
AN ANALYSIS & DISCUSSION:

Despite claims to the contrary the data are clear:
The outcomes for both countries have been remarkably similar.
This has happened in spite of the very different approaches taken.
Several people suspected months ago (I began in March) that, although SARS-CoV-2 was serious, the overall damage was probably overestimated. This post from May forecasts similar outcomes to what we now see.
Yet the narrative says Sweden has "failed". It is true that everyone made mistakes, e.g. care homes, & there have been differences between Sweden & other Scandinavian countries.

However the overall outcome, as shown above, speaks for itself. Sweden & UK are very similar.
Read 13 tweets

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