Nice data from Arizona on the power of mask mandates, CDC, MMWR in controlling surge. Our group analyzing mask mandates and disease severity across counties in U.S. now
cdc.gov/mmwr/volumes/6…
cdc.gov/mmwr/volumes/6…
Nice paper also showing blocking of virus with cloth masks: Aydin O et al. Performance of fabrics for home-made masks against the spread of COVID-19 through droplets: A quantitative mechanistic study. Extreme Mech Lett. 2020 Oct;40:100924. doi: 10.1016/j.eml.2020.100924.
5 more papers around hypothesis of reduced viral inoculum -->less severe disease if exposed (and strong T-cell immunity w/ mild infection). 1) Ferrets given higher viral dose more sick: Dose-dependent response to infection with SARS-CoV-2 in ferrets: doi.org/10.1101/2020.0…
2nd paper: Robust adaptive immune response even with mild infection: Nielson S, Vibholm L et al. SARS-CoV-2 Elicits Robust Adaptive Immune Responses Regardless of Disease Severity. bioRxiv 2020.10.08.331645; doi: doi.org/10.1101/2020.1…. Available at: biorxiv.org/content/10.110…
Papers 3-4: 3. Guallar MP et al. Inoculum at the time of SARS-CoV-2 exposure & risk of disease severity. Int J Infect Dis. 2020. pubmed.ncbi.nlm.nih.gov/32553720; 4. Little P Reducing risks from coronavirus transmission in the home—the role of viral load. BMJ. bmj.com/content/369/bm…
Also, interesting recent preprint: 6.Karimzadeh S et al. Review of Infective Dose, Routes of Transmission, and Outcome of COVID-19 Caused by the SARS-CoV-2 Virus: Comparison with Other Respiratory Viruses . Preprints 2020, 2020070613. Available at: preprints.org/manuscript/202…
We are trying to review now all the literature on pathogen dose and incubation period shortening/severity disease influencing to put together. But whatever you "believe" about masks (I think data compelling), still don't think ridiculing or yelling at one another appropriate.
Convince by adding to database, giving examples of correlation (yes, hard to prove causation but the more and more data behind something, it elevates from hypothesis to theory), etc. Finally, I stick to position that lockdowns hurt poor disproportionally so masks+ distancing
plus selective testing + isolation/quarantine + contact tracing until we get to safe/effective vaccine. Facial masks are hard to adapt to so want to keep accumulating convincing data in order to deliver message with love, compassion, not-yelling, harm reduction way.
Okay that is my long twitter moment after being away. Continue good work and respectful dialogue my friends.
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