Six Potential Treatments for COVID19 Identified using AI
cytokine storm🚫
- antifibrinolytic agent aprotinin
- ang II blocker irbesartan
blood clotting and inflammation🚫
- caplacizumab
- ezetimibe/atorvastatin
MoA not specified
- lycopene
- vitamin D
medscape.com/viewarticle/93…
cytokine storm🚫
- antifibrinolytic agent aprotinin
- ang II blocker irbesartan
blood clotting and inflammation🚫
- caplacizumab
- ezetimibe/atorvastatin
MoA not specified
- lycopene
- vitamin D
medscape.com/viewarticle/93…
Website with many links and other potential drug repurposing candidates, such as hydrocortisone and doxycycline biovista.com/solutions/proj… 
Aprotinin
A bit of a strange finding, used to reduce bleeding during complex surgery (heart/liver). Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots
…-publications.onlinelibrary.wiley.com/doi/pdf/10.111…
academic.oup.com/bja/article/11…
pubmed.ncbi.nlm.nih.gov/7543841/
A bit of a strange finding, used to reduce bleeding during complex surgery (heart/liver). Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots
…-publications.onlinelibrary.wiley.com/doi/pdf/10.111…
academic.oup.com/bja/article/11…
pubmed.ncbi.nlm.nih.gov/7543841/
Might be due to the fact that aprotinin has been found to be a TMPRSS2 inhibitor, same MoA as e.g. camostat
drugtargetreview.com/wp-content/upl…
drugtargetreview.com/wp-content/upl…
Irbesartan
Our recent systems biology study suggested several repurposable drugs for potential treatment of COVID-19, including melatonin and angiotensin II receptor blockers (ARBs) i.e., irbesartan
thelancet.com/journals/ebiom…
Our recent systems biology study suggested several repurposable drugs for potential treatment of COVID-19, including melatonin and angiotensin II receptor blockers (ARBs) i.e., irbesartan
thelancet.com/journals/ebiom…
Caplacizumab
A bivalent Single-domain antibody (VHH) designed for the treatment of thrombotic thrombocytopenic purpura and thrombosis.
Severe COVID-19 is a Microvascular Disease ahajournals.org/doi/pdf/10.116…
A bivalent Single-domain antibody (VHH) designed for the treatment of thrombotic thrombocytopenic purpura and thrombosis.
Severe COVID-19 is a Microvascular Disease ahajournals.org/doi/pdf/10.116…
Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications nature.com/articles/s4158…
COVID-19 is, in the end, an endothelial disease academic.oup.com/eurheartj/arti…
COVID-19 is, in the end, an endothelial disease academic.oup.com/eurheartj/arti…
ezetimibe/atorvastatin
Risk assessment: Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK
ncbi.nlm.nih.gov/pmc/articles/P…
Combination been mentioned previously (not Covid-19 related): thailandmedical.news/news/combinati…
Risk assessment: Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK
ncbi.nlm.nih.gov/pmc/articles/P…
Combination been mentioned previously (not Covid-19 related): thailandmedical.news/news/combinati…
Lycopene:
Previous assessment (not Covid-19): Although lycopene from tomatoes has been tested in humans for cardiovascular diseases and prostate cancer, no effect on any disease was found.
web.archive.org/web/2017072210…
efsa.onlinelibrary.wiley.com/doi/abs/10.290…
Previous assessment (not Covid-19): Although lycopene from tomatoes has been tested in humans for cardiovascular diseases and prostate cancer, no effect on any disease was found.
web.archive.org/web/2017072210…
efsa.onlinelibrary.wiley.com/doi/abs/10.290…
Vitamin D
Several AI's have now come to the same conclusion regarding vitamin D
Several AI's have now come to the same conclusion regarding vitamin D
Identification of potential treatments for COVID-19 through artificial intelligence-enabled
phenomic analysis of human cells infected with SARS-CoV-2
biorxiv.org/content/10.110…
phenomic analysis of human cells infected with SARS-CoV-2
biorxiv.org/content/10.110…
Preprint from a collaboration between NIH, King's College London, University of Purdue, Oxford, Auckland, Concepcion, Virginia, and Lübeck:
https://twitter.com/RHCMcG/status/1285293367702614016?s=20
Oak Ridge supercomputer finds link to bradykinin and RAS / vitamin D
elemental.medium.com/a-supercompute…
elemental.medium.com/a-supercompute…
https://twitter.com/MartinJuhl2/status/1314877659017609216?s=20
A thread on seasonality with additional links to vitamin D
https://twitter.com/MartinJuhl2/status/1314877624347496450?s=20
Disclaimer: I am not a medical doctor and I am only sharing data, thus this should not be seen as a recommendation for the various treatments as such
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