In Young Adults, certain health factors predict the risk of mod-severe #COVID19:
👉BMI > 30
👉Fatty liver (increases risk 6-fold)
👉Ectopic fat in the kidney, albuminuria
👉BMI > 30
👉Fatty liver (increases risk 6-fold)
👉Ectopic fat in the kidney, albuminuria
1) academic.oup.com/cid/article/71…
thelancet.com/journals/lance…
2)ncbi.nlm.nih.gov/pmc/articles/P…
3) onlinelibrary.wiley.com/doi/10.1002/ob…
thelancet.com/journals/lance…
2)ncbi.nlm.nih.gov/pmc/articles/P…
3) onlinelibrary.wiley.com/doi/10.1002/ob…
Risk factors for inpatient mortality from #COVID19:
Obesity (OR 1.7, 1.1-2.8)
Male (OR 5.2, 1.6-16.5)
Older age (OR 1.3, 1-1.6)
*After adjusting for age, gender, and comorbid...for every increase from one BMI category to the next, there was a 70% increased odds of mortality."
Obesity (OR 1.7, 1.1-2.8)
Male (OR 5.2, 1.6-16.5)
Older age (OR 1.3, 1-1.6)
*After adjusting for age, gender, and comorbid...for every increase from one BMI category to the next, there was a 70% increased odds of mortality."
In one study from NYC, 41.7% of patients hospitalized for #COVID19 had obesity (BMI>/= 30).
jamanetwork.com/journals/jama/…
jamanetwork.com/journals/jama/…
Why the association? There are several hypotheses:
👉chronic inflammation in OB predisposes to cytokine storm
👉interleukin dysregulation impairs immune defense against virus
👉Physiological impaired respiratory function (⬇️diaphragmatic excursion)
👉Thrombogenic state
👉chronic inflammation in OB predisposes to cytokine storm
👉interleukin dysregulation impairs immune defense against virus
👉Physiological impaired respiratory function (⬇️diaphragmatic excursion)
👉Thrombogenic state
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