In Young Adults, certain health factors predict the risk of mod-severe #COVID19:
👉BMI > 30
👉Fatty liver (increases risk 6-fold)
👉Ectopic fat in the kidney, albuminuria
Risk factors for inpatient mortality from #COVID19:

Obesity (OR 1.7, 1.1-2.8)
Male (OR 5.2, 1.6-16.5)
Older age (OR 1.3, 1-1.6)

*After adjusting for age, gender, and comorbid...for every increase from one BMI category to the next, there was a 70% increased odds of mortality."
In one study from NYC, 41.7% of patients hospitalized for #COVID19 had obesity (BMI>/= 30).

jamanetwork.com/journals/jama/…
Why the association? There are several hypotheses:
👉chronic inflammation in OB predisposes to cytokine storm
👉interleukin dysregulation impairs immune defense against virus
👉Physiological impaired respiratory function (⬇️diaphragmatic excursion)
👉Thrombogenic state

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More from @MikeAlbertMD

17 Oct
1/ WHY INCREASING PHYSICAL ACTIVITY/EXERCISE SHOULD BE A GREATER FOCUS THAN LOSING WEIGHT:

I still think a weight-centric approach to managing chronic dz is the best approach, but if you are going to focus on ONE change in your life, I hope it is increasing PA.
[thread]
2/ To understand my point you need context. First, losing WT and maintaining it is hard. I could give you any number of obscure stats on this, but I think you all know from experience. The obesogenic environment (sedentary life + modern UPFs food) is unforgiving.
3/And while I think we should cont to manage our Wts the best we can (lifestyle/meds/surgery), THE SYSTEM is rigged against us. Until we address the systemic issues driving OB (food deserts, health inequity, poverty, agricultural subsidies, etc.) major changes will not occur. Image
Read 13 tweets
10 Aug
1/ "MASK"ING THE CASE: WHY THERE SHOULD BE A UNIVERSAL MASK MANDATE

I have been fascinated by the discussion around mask use during the pandemic. Suffice it to say, the US' compliance has not been great considering the size of the current outbreak across the US states. [thread]
2/In fact, as recently as July 2020, there was a only ~48% chance everyone would be masked during five random public encounters.

original article: nytimes.com/interactive/20…
3/So why all the lack of compliance with mask use? Do masks really reduce the risk of COVID19 transmission? Let us jump in...[thread]
Read 24 tweets
26 Jul
1/ #OBESITYSERIES 2: WHY COMMON OBESITY IS NOT A CHOICE

A large number of people, including physicians, believe that obesity is a consequence of a person's moral character or poor choices. The reality could not be farther from the truth. Let's jump in...
2/ WHY DOES OBESITY OCCUR?

There are many contributors to OB both int. as well as extnl factors. However, the OB epidemic is a relatively new phenomenon that has only been present since the 1970s. Most believe it is due to the convergence of our biology w/ modern food environ.
3/ We are consuming a lot more food. Our best calculations estimate the modern OB epidemic to be the result of an additional 200 kcal of food per day. H/t @KevinH_PhD and @whsource
Read 23 tweets

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