Covid Epi Weekly: Death Won’t Take a Holiday this Holiday Season

Divided government. Divided country. Just when we most need unity to stop the pandemic. Covid skyrocketing. 100-fold difference between S Dakota and Vermont, and 10x between northeast and upper midwest. 1/thread
How bad is the increase? Bad. Doubling, tripling of cases or more in many communities and states. Much of the country is in the exponential increase phase. Every day of delay cost lives. Basic concept: 1-2 punch. 1: Knock virus down, minimizing social harm. 2: Keep it down. 2/14
First, the numbers. Bad almost everywhere. CDC understatement: “Percent positivity increased [7.2% to 8.2%] among all age groups ... in all regions.” Horrifying. National tsunami. Hospitalizations up 14%, deaths up 8%. Deaths follow hospitalizations by a week or two. 3/14
Huge thanks to covidexitstrategy.org for great work. We hope site and others will be put out of business by a competent Federal response that demonstrates the only enemy is a virus and gets us all on the same page. The more we work together, the more we can control Covid. 4/14
Hospitalization increases required exit strategy team to add a new color. Upper midwest is in the exponential increase phase. Here’s the key point: per capita hospitalization rates for Covid range from 500 per million to <50/million. 10-fold difference. Policy matters!! 5/14
One of the most frustrating aspects of the attention to Covid has been continued focus on the wrong numbers. Cases are only about one fifth of infections, and vary based on testing. Test-intensity weighted ranking/incidence helps. Varies 100-fold from S Dakota to Vermont! 6/14
We are waking up to truth: we need to shut down. We can do this sensibly. Keep schools, childcare, universities, shopping, ?barber shops, other areas open - ONLY with rigorous safety measures & modification. Reduce travel, risky indoor gatherings. Great example from Ireland. 7/14
Like oh-so-much-too-much in our society, Covid hurts the most vulnerable most. Rates vastly higher in American Indian, Latinx, Black/African American people. The virus doesn’t stay in any group - we’re all connected. The more safe we all are, the more safe we all will be. 8/14
Punch 1: Knock the virus down with strategic closures. We’ll do that sooner or later. But we need to vastly up our game with Punch 2: Reduce the time from infectivity to isolation. Paid sick leave for all. Rapid testing, rapid isolation - reduce infectious burden. 9/14
Stunningly study. Very high attack rate among children in families with Covid: 77%! bit.ly/3k0pdr6

Other studies find lower rates, but bottom line: not helping Covid patients relocate during maximum infectivity extends explosive spread by weeks or months. 10/14
We must discover more. How to not leave infectious people at home. bit.ly/3mSeKzM How to best use tens of millions of antigen tests being sent out. Validity? Utility? How to scale production of N95 (including safely reusable) and surgical masks? 11/14
Important: Success is possible. It takes rigor, discipline, patience, and working together. Good article in today's @CDCMMWR showing impact of closures, masks. Not as fast as we'd like, but it works. bit.ly/3p1oGsB 12/14
Covid fatigue is understandable. We all feel it. Excellent report from WHO EURO:
* Understand and empathize
* Engage communities to find solutions
* Reduce restrictions but protect lives
* Be transparent, consistent, predictable, and fair.

bit.ly/38r3y9c

13/14
The sooner we shut, the softer and shorter we can shut. We can minimize disruption to holiday shopping, jobs, and education, and also find and reduce the major drivers of spread. To have happier holidays at the end of the year, we must stay much safer for next 6 weeks. 14/end

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More from @DrTomFrieden

30 Oct
Covid Epi Weekly: Scariest. Halloween. Ever.

Hard to imagine a worse confluence. Cases surging in much of US. People are tired of limitations the virus is imposing. Economic harm is real, painful, and persistent. White House communications continue to mislead, divide, deny. 1/
Bottom line (almost) up front: there IS one thing that can stop Covid. For months I’ve said there isn’t, but there is one thing. Not masks. Not travel limitations. Not staying home. Not testing. Not contact tracing. Not isolation. Not quarantine. Not even vaccine.

It’s TRUST.
2/
Around the world, the best predictor of controlling Covid is social cohesion. The understanding that we’re all in this together. We’re all safer when we all mask up, support tracing, and, eventually, get vaccinated. No group can get infection without endangering others. 3/
Read 21 tweets
24 Oct
Covid Epi Weekly: Turning the Corner on Covid in the US ... Into an Oncoming Tsunami of Cases, Hospitalizations, and Death

You know who’s NOT tired of winning? Covid, that's who. Unless we up our game, it will keep winning, keep spreading, keep killing Americans preventably.

1/
Test positivity increasing in ALL age groups. Positivity in >65s increased 44%, from 3.6% 5 weeks ago to 5.2%; 5 weeks ago rate in young adults was 50% higher than in over 65s; last week 20% higher. What started in the young didn’t stay in the young. 2/
bit.ly/3jq6k0n
Cumulative hospitalizations people >65 in US
1 in 300 Caucasians
1 in 120 American Indian/AN
1 in 110 Latinx
1 in 87 (!) Black people

Covid+ failure to protect essential workers, many Black/Latinx+ baseline less access to healthcare = exacerbated racial injustice in health. 3/
Read 14 tweets
16 Oct
Covid Epi Weekly: Immunizing Against Herd Stupidity

Bad week for fight against Covid. Reopening without sufficient care. Failure to isolate. Failure to communicate. Dangerously misguided theory on immunity. Cases increasing, hospitalizations following, more deaths to come. 1/15
Test positivity increased for first time in a month (to 5.4%), but positivity difficult to interpret. Antigen tests, lack of consistent definitions. bit.ly/30Fj11C Hospitalization data concerning tho in the crazy world of US health economics supply creates demand. 2/15
In the past 2 weeks, 21 states had their highest reported rates ever, including most of the midwest, much of the west. As predicted, we have surpassed 50,000 cases/day. White House cluster up to 40 known cases, hundreds not untested. Maine and Vermont still encouraging. 3/15
Read 14 tweets
9 Oct
Covid Epi Weekly: The First Cluster

Cluster at White House is symptom and symbol of the failure of Federal response. Overconfidence in testing. Lack of basic safety precautions in crowded indoor places. Delayed isolation. Incomplete contact tracing. Failure to quarantine. 1/13
Testing only useful as part of a comprehensive strategy; it doesn’t replace safety measures. There are false negatives, and even if accurately negative in morning someone can be highly infectious hours later. Also need 3W’s: wear a mask, watch your distance, wash your hands. 2/13
Masks are important. Worth reading science review by the wonderful @CyrusShahpar. I learned from it. In addition to protecting others & yourself, masks may reduce inoculum and make it more likely that if you do get infected you won’t get severely ill. 3/13 bit.ly/36UK4tb
Read 13 tweets
5 Oct
We still don't know key elements about the Covid outbreak affecting the White House. This is what needs to happen to assess the outbreak's impact and stop continued spread. 6 steps in an epidemiologic investigation:
Step 1: Establish the case definition: person, place, and time. For example, someone who had contact with anyone in the White House after September 18 and has a positive test for Covid (confirmed) or symptoms consistent with Covid (suspected).
Step 2: Find all who meet the case definition through active surveillance.
Read 8 tweets
2 Oct
Epi Weekly. 40 million plus 1. And…NYC is on the brink of a precipice.

A minimal estimate is about 40 million infections in the United States with the virus that causes Covid. The infection of President Trump is the most prominent, and one of the most telling.

First of thread/
My thoughts are with the President, First Lady, family, and all others infected with and affected by Covid. The President’s infection is a reminder that Covid is an ongoing threat. No one is safe – not even heads of state – until everyone is safe. fxn.ws/3ioVuaG
2/16
Risk of severe illness and death increases with age. A 74-year-old has approximately 3% chance of death, higher in males and people who are obese, and much higher if hospitalization is required. 85-90% of those infected in their 70’s will have no, mild, or minor illness.
3/16
Read 16 tweets

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