Hospitals are getting full. There is still widespread practitioner ignorance about early treatment.
These are the antivirals proven to work in RCT against COVID-19 to date.
There are others that also look promising, but this is the short list.
Do with it what you will.
These are the antivirals proven to work in RCT against COVID-19 to date.
There are others that also look promising, but this is the short list.
Do with it what you will.
https://twitter.com/__ice9/status/1321149210285297665
Addendum, as many replies mentioned other promising options that nonetheless still lack proper RCTs:
Each item on this list appears to have attainable EC90 based on pre-clinical data, and most have observational evidence in favor, but no RCT to date.
https://twitter.com/__ice9/status/1328253352824745984?s=19
Each item on this list appears to have attainable EC90 based on pre-clinical data, and most have observational evidence in favor, but no RCT to date.
Also note the following options (not all of which are antivirals per se) are available OTC in at least some countries:
https://twitter.com/__ice9/status/1307927834267136000?s=19
Among the OTC items, personally, I would place particular emphasis on aspirin.
Aspirin is not an antiviral in any sense against SARS-CoV-2. It is an antiplatelet drug. In high risk cases, limiting platelet activation is extremely important.
https://twitter.com/farid__jalali/status/1326394936955183105?s=19
Aspirin is not an antiviral in any sense against SARS-CoV-2. It is an antiplatelet drug. In high risk cases, limiting platelet activation is extremely important.
Dipyridamole is another antiplatelet drug with a different and broader mechanism of action. It may also have antiviral effects.
It performed quite well in a Chinese COVID-19 RCT. A larger U.S. RCT is being conducted by @YogenKanthi and @jasonsknight.
It performed quite well in a Chinese COVID-19 RCT. A larger U.S. RCT is being conducted by @YogenKanthi and @jasonsknight.
https://twitter.com/__ice9/status/1274239127567896576?s=19
Interventions in moderate and severe cases, mostly non-antiviral, performing well in RCTs and controlled observational studies:
This table was meant for hospital cases. Think SpO2 on room air below 90%. Unfortunately, admission is no longer guaranteed.
https://twitter.com/__ice9/status/1307408819098718208?s=19
This table was meant for hospital cases. Think SpO2 on room air below 90%. Unfortunately, admission is no longer guaranteed.
It is very important to obtain medical evaluation and potentially hospital admission if SpO2 falls below 90-92%.
Buy a pulse oximeter. Keep it with your thermometer. Use it.
Please also watch for signs of pulmonary embolism, a medical emergency.
Buy a pulse oximeter. Keep it with your thermometer. Use it.
https://twitter.com/__ice9/status/1327263123334688768?s=19
Please also watch for signs of pulmonary embolism, a medical emergency.
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