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The Mental Elf

17 Nov, 13 tweets, 9 min read

@pimcuijpers

Our next talk at #IEPA12 is by @pimcuijpers from @VUamsterdam who will be focussing on preventing the onset of depressive disorders: the opportunities and challenges pimcuijpers.com/blog/

“I’m always happy to talk about research on preventing the onset of depression", as there are lots of opportunities for helping people, says Cuijpers #IEPA12

@JAMA

Preventing depression: a global priority

This 2012 viewpoint by Cuijpers in @JAMA made the case for depression prevention and highlighted that the global biomedical community were ready for this idea (preventing depression) #IEPA12

doi.org/10.1001/jama.2…

@pimcuijpers

Why is it important to prevent depression?
@pimcuijpers speaking at #IEPA12

-high prevalence & incidence
-huge burden of disease
-it’s not good enough to wait for people to get ill and treat them
-AND our treatments aren’t good enough!

Treatments only take away 16% of the disease burden of major depression. If we gave everyone an evidence-based treatment we would only take away 34% of the burden, says Cuijpers
(Andrews, 2004, BJPsych)

We need better treatments for depression!
#IEPA12

@TheLancetPsych

The economic costs of depression (absenteeism/presenteeism) are very high

Dan Chisholm 2016 @TheLancetPsych: doi.org/10.1016/S2215-…
#IEPA12

Meta-analysis of RCTs - can we actually prevent depression? (Cuijpers in revision - updating previous reviews)

-50 trials (1 universal prevention, 16 selective, 33 indicated) across different populations
-using CBT (22), IPT (8) and stepped care (5)
#IEPA12

This review (preliminary unpublished results) shows that indicated AND selective prevention are effective at reducing incidence of depression, BUT the effects are modest:
-Indicated prevention IRR = 0.81
-Selective prevention IRR = 0.79
#IEPA12

Preventing depression is best (if possible) BUT we also need better treatments!

We can potentially improve effects by focusing on multiple disorders (e.g. anxiety and depression) or using stepped care models, says Cuijpers #IEPA12

@IoanaA_Cristea

Read @IoanaA_Cristea’s blog of @pimcuijpers 2016 RCT in @JAMA

"This is the largest depression prevention trial conducted so far and it shows web-based guided self-help to be effective."

nationalelfservice.net/mental-health/…
#IEPA12

@pimcuijpers

Great #IEPA12 talk from @pimcuijpers

Prevention can reduce depression incidence (up to 50%), BUT we need:
-to identify high risk groups with higher incidence rates, e.g. by combining risk factors
-better treatments
-to improve the uptake of interventions

If you’re interested in preventing depression, you should look at the Global Consortium for the Prevention of Depression.

Check out the podcast we recorded at the last #DepressionPrevention meeting in York in 2019 #IEPA12 soundcloud.com/national-elf-s…

@pimcuijpers

And if you fancy a longer listen on preventing depression, you can settle down to the dulcet tones of @pimcuijpers in this 50-min podcast recorded back in 2016 #IEPA12
soundcloud.com/national-elf-s…

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The Mental Elf

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17 Nov

@RodrigoAffonse1

And now it’s time for our final #IEPA12 keynote from Rodrigo A Bressan @RodrigoAffonse1 who is going to talk about Widening the clinical and geographical frontiers of neurodevelopmental studies - the Brazilian High Risk Cohort Study

We’ve heard this statistic a few times during #IEPA12
75% of mental disorders start before age 18. Bressan adds that 50% of mental disorders start before age 14.
So “we need to understand the biology very early on, not after onset”.

When we start identifying people with symptoms we don’t have good predictors of trajectories, says Bressan
#IEPA12

Read 29 tweets

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17 Nov

@L_Arseneault

Our next speaker is Louise Arseneault @L_Arseneault from King’s College London who will be talking about Early intervention for developing positive social relationships: can we prevent bullying victimization and loneliness? #IEPA12

The absence of social relationships, or problematic ones may lead to mental health problems, says Arseneault. At the same time, positive social relationships can protect our health and wellbeing. They are important malleable factors that can be target by interventions. #IEPA12

Transition periods in the human life course (starting school, relationships, jobs and retirement) are potentially tricky times, says Arseneault #IEPA12

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The Mental Elf

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17 Nov

@Families_MH

Our next #IEPA12 plenary talk comes from Juliana Onwumere @Families_MH from King’s College London who will be sharing some “Tales from the frontline: Understanding the impact of psychosis on families”

@TheBJPsych

Onwumere begins by talking about the cognitive model of caregiving in psychosis, which she published with Elizabeth Kuipers and Paul Bebbington in @TheBJPsych back in 2010 doi.org/10.1192/bjp.bp… #IEPA12

We know that people with lived experience of psychosis can have significantly reduced social networks and informal carers can play an important role in these networks #IEPA12

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The Mental Elf

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17 Nov

@CU_ChildPsych

Our first speaker in this #IEPA12 session is Cristiane Duarte (not on Twitter) from @CU_ChildPsych @ColumbiaPsych who will be talking to us about: Intergenerational Psychiatry: A New Look at a Powerful Perspective #IEPA12

Cristiane Duarte is an expert in the development of mental disorders in children, adolescents and young adults #IEPA12

Intergenerational Psychiatry
Duarte is going to talk about:
-definition, animal & human evidence
-role of adversities & perinatal period
-expanding our hypotheses (e.g. mechanisms of transmission)
-the Center for Intergenerational Psychiatry
#IEPA12

Read 27 tweets

The Mental Elf

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17 Nov

Our final speaker in this #IEPA12 session of talk is Eric Chen (not on Twitter) from the University of Hong Kong who will be speaking to us about “Youth mental health in troubled times”

Eric Chen has been leading one of the first early psychosis intervention programmes in Asia: the EASY programme (Early Assessment Service for Young People with Early Psychosis) #IEPA12 www3.ha.org.hk/easy/eng/servi…

Most mental health conditions (75%) start before the age of 25, says Chen #IEPA12

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The Mental Elf

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17 Nov

@golam_khandaker

Our next talk at #IEPA12 is by @golam_khandaker from @psychiatry_ucam who will be discussing the immune system as a potential target for treatment and prevention of serious mental illness and comorbid cardiometabolic diseases

This talk will focus on the potential role of the immune system.

Is inflammation likely to be a causal risk factor for depression, psychoses and comorbid physical illness? #IEPA12

Inflammation: what does it mean and why is it relevant? (when a friend becomes a foe)
-innate immunity (first line of defence) this is the focus on the talk today
-cytokines are similar to neurotransmitters: they enable white blood cells to talk to each other
#IEPA12

Read 22 tweets

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