Thread by @profshanecrotty

1/ Our pre-print on immune memory to SARS-CoV-2 is out today. To our knowledge, this is the largest such study for any acute infection.

The upshot is that there is substantial immune memory after COVID-19.

Lots of stuff in this manuscript.
biorxiv.org/content/10.110…
@SetteLab

2/ We assessed immune memory of all three branches of adaptive immunity (CD4+ T cell, CD8+ T cell, and humoral immunity—both antibodies and memory B cells) in a mixed cross-sectional and longitudinal study of 185 recovered COVID-19 cases, including 41 cases > 6 months post-COVID.

3/ Sources of protective immunity against SARS-CoV-2 may be multifaceted. Therefore, understanding immune memory in a coordinated manner is needed to see the potential complexities and gain insights into the likelihood of durability of protective immunity.

4/ So, this was a big @ljiresearch team effort, led by us, @SetteLab and @Dani6020, with big help from @EOSaphire and @florian_krammer and UCSD clinicians.

5/ By measuring antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2—each for multiple antigens—in an integrated manner, we observed that each type of SARS-CoV-2 immune memory exhibited distinct kinetics, and that memory to SARS2 appear to be robust.

6/ most individuals maintaining neutralizing antibodies for 6+ months, and other forms of immune memory.

7/ Our findings are consistent with earlier work from multiple labs, including @PepperMarion , @deeptabhattacha , and Nussenzweig and others, on components of immune memory and/or earlier memory, which is great!