Alina Chan Profile picture
21 Nov, 18 tweets, 7 min read
USA getting close to 200,000 new daily covid cases and ~1000 covid deaths per day.

An estimated 50 million travelers this Thanksgiving. Some may have already started their trip home this weekend.

Don't need magical powers to see this will won't go well.

technologyreview.com/2020/11/14/101…
For those still on the fence, please consider alternatives to in-person Thanksgiving.

On top of the regular Zoom, Skype, Facetime, Whatsapp meetings, you can:

(1) Watch movies and Netflix with your family using Teleparty netflixparty.com
I recommend Crash Landing on You.
(2) Play super fun app/online games.

Jackbox games - I like Drawful and Trivia Murder Party. jackboxgames.com/how-to-play/

Among Us - Murder your family and friends digitally instead of at Thanksgiving dinner. cnet.com/how-to/among-u…
(3) Go on virtual tours with your family and friends. You can keep your Zoom meeting on during the tour.

Here's one of the White House 360virtualtour.co/portfolio/the-…

Better ideas here:
forbes.com/sites/laurabeg…
(4) If you want to jazz up your typical online meeting, consider:

A virtual party room you can customize spatial.chat

Animal crossing
theverge.com/2020/4/8/21212…

I promise I'm not earning any commission from these apps I'm recommending.
Consider that you can immediately hang up on your parents & relatives when they start questioning all of your life choices, why you don't have kids, how you compare to your siblings or cousins, why you never became a real doctor (and why you're now a twitter conspiracy theorist).
But if you're set on going home for Thanksgiving, please plan out how you're going to maintain social distancing, minimize risk of superspreading, and have a clear outline of the steps to take if someone in your circle tests positive in the weeks to come.
massgeneral.org/news/coronavir…
Estimate the risk of attending a gathering, given the event size and location covid19risk.biosci.gatech.edu

Consider whether or not to exclude relatives who are college students or people whose jobs expose them to a lot of people in the community on a regular basis.
If possible, have a call with all attending family+friends first to establish some ground rules to keep everyone safe, e.g.,

(1) No Thanksgiving party hopping.
(2) Staying outdoors + socially distanced as much as possible.
(3) Immediately telling everyone if you feel unwell.
Plan what to do when you return from Thxgiving. Maybe you were 💯responsible, but this doesn't apply to everyone. A lot of people in this country still don't think that this virus is a real public health concern.

A Thanksgiving hike in cases is expected.
cnn.com/2020/11/21/hea…
If possible, have conversations with your employers pre-Thxgiving to ensure that there are no incentives/pressure for people to come into work immediately after Thanksgiving. Many of us have our biases, e.g., I was safe, I'm healthy, there's no way I could have gotten covid.
On this note, Zoom announced that it will lift its 40-minute time limit for free meetings on Thanksgiving (November 26). #Zoomsgiving

cnn.com/2020/11/17/tec…
I think it's incredibly important to walk through the steps of what to do if you find out someone at your Thanksgiving is covid-positive. This is likely going to happen across 100,000s of households over the next few weeks, although there are measures you can take to reduce risk.
(1) If someone is sick, stay home first, don't go to CVS or to the hospital. Prepare for the worst - assuming that they have covid - pick 1 person to be their caregiver, isolate both of them, but the entire household should also quarantine separately.
massgeneral.org/news/coronavir…
(2) Call your doctor to walk through the symptoms and decide whether to visit the hospital/call an ambulance.

If possible, put together a basic kit before Thanksgiving: thermometer, disinfectant wipes, tissues, painkillers, cough syrup/lozenges so that you have all this ready.
I know these sound like an overreaction to a lot of people who don't think they will develop severe covid. We often hear about the fatality rate but not the rate of developing severe covid, which is considerably higher even for younger people, especially with pre-existing issues.
Back in January, I started putting together my covid kit. Yes, this disease isn't as fatal as SARS1 or Ebola. But if your entire city succumbs to mass outbreaks, you will be faced with a shelter-in-place/lockdown and overflowing hospitals+CVSs, which will become covid hotspots.
I'm really glad that I did not have to use this kit so far (except for the TP) this year, but it still gives me a peace of mind knowing that I have it in case the worst case scenario happens.

Good lists here: healthline.com/health/stockin…

And here: cnn.com/2020/10/27/hea…

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More from @Ayjchan

20 Nov
Went from helping to co-organize the @sciencepolicy conference to being a #CSPC2020 topic.

How can scientists address questions that have been painted as conspiracy theories? And without amplifying or legitimizing misinformation related to these questions.

Thanks @Sciencish
Good tips in this graphic by @CaulfieldTim
Definitely: Always consider the body of available evidence on the topic, recognizing that science evolves.
As a scientist who has been washed out to sea on a contentious covid topic, I find it safest to talk to science journalists for news articles - professionals with some extent of scientific training, who know what to ask scientists, how to probe their reasoning and evidence.
Read 5 tweets
18 Nov
Yea, I don’t see how @TheLancet or @EcoHealthNYC can possibly be regarded as appropriate parties in a credible independent investigation of #originsofsarscov2
Based on the emails unearthed by @USRightToKnow EcoHealth was already circulating this letter by Feb 6. The virus had only been announced on Jan 20 to transmit from human to human; its genome released on Jan 12 was barely characterized at least publicly.
thelancet.com/journals/lance…
If you've been going around rallying other scientists to condemn lab origins as a conspiracy theory since the beginning of the pandemic, how can you possibly “systematically examine every theory” “not be bound by preconceived ideas” “with an open mind” telegraph.co.uk/global-health/…
Read 34 tweets
18 Nov
On the covid data sharing debate, I believe that the context of a raging pandemic killing millions of people should be considered 1st. If a scientist finds that there is rapid virus adaptation in minks, must they seek permission or wait for the data providers to publish first?
I know that some scientists on both sides of this issue think that the same data sharing protocol applies to pandemic data as it does to non-pandemic data. But I don't think so.

Pandemic data should be shared in real time, analyzed in real time, publish/preprinted in real time.
In non-pandemic times, it makes sense to let the data provider take precedence; no urgency.

But in pandemic times, if you can do the analysis differently, faster, or better, shouldn't it be released ASAP? Especially if data is already shared only months after sample collection?
Read 6 tweets
17 Nov
Pandemic rages. Meanwhile scientists are fighting about what open data sharing means and whether you can publish analysis using someone's data if part of their dataset has not yet been published.
For a layperson, what is the issue here?

Scientists often keep data private so that they can publish in high impact journals and avoid others beating them in the publication race.

If you share data pre-publication, others are likely to swoop in and you lose your advantage.
In the pandemic, we've seen scientists really step up their data sharing generosity. It's the only way global databases @GISAID, public resources @nextstrain @covidcg can provide big picture, powerful analyses of SARS2. So many analyses have been run on unpublished sequences.
Read 19 tweets
17 Nov
“if a similar phenomenon of host adaptation had occurred upon its jump into humans, those human-specific mutations would likely have reached fixation.. before the first SARS-CoV-2 genomes were generated.” 🙏🏻 ⁦@LucyvanDorp⁩ ⁦@BallouxFrancoisbiorxiv.org/content/10.110…
"The secondary host jump from humans into minks offers a glimpse into the window of early viral host adaptation of SARS-CoV-2 to a new host that has likely been missed at the start of the COVID-19 pandemic... and point to rapid adaptation of SARS-CoV-2 to a new host." 💯🔥
"pandemic is understood to have been caused by a unique host jump into humans from a single yet-undescribed zoonotic source in the latter half of 2019"

How does this fit with: "human-specific mutations would likely have reached fixation.. before the first SARS-CoV-2 genomes" 🤔
Read 4 tweets
16 Nov
It looks like the universe will not let me have a day off.

@Nature just released an Addendum on the WIV's first paper about COVID, explaining what's up with RaTG13, the bat coronavirus most closely related to SARS-CoV-2. nature.com/articles/s4158…
tldr from the Mojiang mine, 293 CoVs found, 9 were SARS CoVs, 1 was RaTG13 first published in 2016 (not cited in their original 2020 @Nature paper). The other 8 SARS CoVs? We have no insight to their sequences!
Why are we hearing about this in mid-Nov 2020 when their paper was released in January, saying that they first found a match in the RdRp between RaTG13 and SARS-CoV-2 and then full genome sequenced RaTG13 to find a 96.2% genome identity match?
Read 20 tweets

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