Eric Topol Profile picture
Nov 28, 2020 5 tweets 5 min read Read on X
This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive.
I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months. Image
There are several points noteworthy related to this timeline:
1. Moderna had a head-start, so why didn't their Phase 3 trial finish first?
Part of #OperationWarpSpeed (OWS), they were requested to slow down enrollment to get better minority representation
nytimes.com/2020/11/21/us/… Image
2. 3 scientists led the way
Katalin Karikó, worked on a mRNA vaccine for ~30 years, was demoted from @PennMedicine d/t losing her grants, went to @moderna_tx
statnews.com/2020/11/10/the…
and the husband and wife team @BioNTech_Group
nytimes.com/2020/11/10/bus… ImageImage
3. The 5 days from sequencing the virus to design of an mRNA vaccine, relayed by Tony Fauci in our conversation
@Medscape Image
4. Whose idea was OWS and when did it kick in?
Peter Marks @US_FDA
nytimes.com/2020/11/21/us/… @SharonLNYT
It was announced May 15th
defense.gov/Explore/Spotli… Image

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More from @EricTopol

Jan 22
Breaking down the risks and benefit for lecanemab, the amyloid beta-directed antibody vs Alzheimer's drug approved @US_FDA last year. It doesn't look good.

@AnnalsofIM acpjournals.org/doi/10.7326/M2…
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A new systematic review of these antibodies looks even worse @AnnFamMed doi.org/10.1370/afm.30…



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Fixed link for this important paper
annfammed.org/content/22/1/5…
Read 4 tweets
Jan 4
My oped on the JN.1 variant and the 2nd biggest US wave of infections (after Omicron) since the pandemic began
@latimes @latimesopinion #LongCovid latimes.com/opinion/story/…
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Recent @CDCgov #SARSCoV2 wastewater data for current wave (vs Omicron Jan 2022 and subsequent waves), graph by @luckytran Image
Sorry, @washingtonpost, but this is not "another Covid-19 uptick" as you put it in your Health Alert. You ignore the best metric for infections that we have at present—wastewater—focusing only on hospitalizations
washingtonpost.com/health/2024/01…
Image
Read 4 tweets
Nov 23, 2023
3 New #LongCovid reports
1. Vaccination protection—1 dose 21%, 2 doses 59%, 3 doses 73% among ~590,000 people in Sweden (strong association)
bmj.com/content/383/bm…
Image
2. 3-year prospective follow up of a cohort of ~1350 participants, hospitalized in China
—Lung function restored back to baseline in most
—Higher risk of reinfection that people w/o Long Covid
—Half w/ persistent symptoms
thelancet.com/journals/lanre…
3. At @RSNA annual meeting, brain MRI with microstructure imaging (DMI), participants with #LongCovid vs controls had microstructure changes associated with impaired cognition, sense of smell and fatigue
eurekalert.org/news-releases/…
Image
Read 6 tweets
Aug 25, 2023
Big news #ESC2023 and @NEJM
In a placebo-controlled randomized trial of people with obesity + heart failure (with preserved ejection fraction). semaglutide (Wegovy) markedly improved symptoms, exercise time, reduced inflammatory markers (and weight loss)
nejm.org/doi/full/10.10…

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This also tells us something about the underlying mechanism of heart failure with preserved EF—metabolic dysfunction and attendant systemic inflammation—not previously acknowledged or confirmed
The accompanying editorial lays this finding out well. Prior studies of weight loss didn't help HFpEF
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Read 4 tweets
Aug 21, 2023
Two new papers @NatureMedicine and @JAMAInternalMed shed light on #LongCovid at 2-years. But there's no shortage of known unknowns.
Reviewed in a new Ground Truths (link in my profile, because that would be it X-suppressed) Image
Links to the new reports
@NatureMedicine by @zalaly and colleagues
@JAMAInternalMed nature.com/articles/s4159…
jamanetwork.com/journals/jamai…
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@NatureMedicine @zalaly @JAMAInternalMed Summary of previous 2-year Covid follow-up studies Image
Read 5 tweets
Aug 4, 2023
The EG.5 variant continues to show a growth advantage in the latest US genomics surveillance, from 11->17% in past 2 weeks
FL.1.5.1 also on the rise. The XBBs are on the wane. https://t.co/50Eq338zXLcovid.cdc.gov/covid-data-tra…
Image
EG.5.1 rise seen in many other places, nicely summarized in @kallmemeg 's thread about the new @UKHSA report
https://t.co/Ba3GZmwVWF
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Highlighting the evolution of these variants from XBB in @dfocosi's convergence map. The added F456L mutation may reflect impact of monoclonal antibody treatment escape mutation (see ) https://t.co/bZtWCt1oMH
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Read 5 tweets

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