and 12-19:
12/19- 5.In another study healthy women were fed two diets containing a reduced amount of total and saturated fat, with either low or high in vegetables, berries, and fruit. While LDL-C declined, Lp(a) increased 7-9% ncbi.nlm.nih.gov/pubmed/14739118
12/19- 5.In another study healthy women were fed two diets containing a reduced amount of total and saturated fat, with either low or high in vegetables, berries, and fruit. While LDL-C declined, Lp(a) increased 7-9% ncbi.nlm.nih.gov/pubmed/14739118
13/19- 6.Weight loss also tends to increase Lp(a), particularly in patients with small isoforms. ncbi.nlm.nih.gov/pmc/articles/P… 
14/19-7.On the other hand, plant based diets seem to lower Lp(a) and all atherogenic lipoproteins. ncbi.nlm.nih.gov/pubmed/30014498
15/19- So, bottom line:
1-Lp(a) levels often go in opposite directions to LDL-C, except with plant based diet in 1 study.
2-Low carb/high fat diet tends to lower Lp(a) but increase LDL-C.
3-In contrast, mono and poly rich diets tend to increase Lp(a) but have many benefits
1-Lp(a) levels often go in opposite directions to LDL-C, except with plant based diet in 1 study.
2-Low carb/high fat diet tends to lower Lp(a) but increase LDL-C.
3-In contrast, mono and poly rich diets tend to increase Lp(a) but have many benefits
16/19- 4-Weight loss tends to increase Lp(a)
5-Dietary effects on Lp(a) tend to be modest and not clear if clinically significant
6- data on pts with high Lp(a)/small isoforms is rare
7- more research on diet and Lp(a) is needed and very important
5-Dietary effects on Lp(a) tend to be modest and not clear if clinically significant
6- data on pts with high Lp(a)/small isoforms is rare
7- more research on diet and Lp(a) is needed and very important
17/19- My recommendation to pts with high Lp(a): Mediterranean diet- taking into account pros/cons, using mono, mainly olive oil, which is resistant to oxidation, palatability and ability to maintain over a lifetime.
Diets that raise LDL-C are not advised
Diets that raise LDL-C are not advised
18/19-Finally, it may be more important on ‘how much” one eats, vs “what’ one eats. Easier said than done, but all calories are calories. Make them worth eating and chose the best types.
19/19 Knowledge of diet continues to evolve, and it is bigger than Lp(a). Since Lp(a) is mainly a genetic factor, we need to overcome our genes to manage well in future.
There will be no quiz today, this topic is too complex with many unanswered questions.
There will be no quiz today, this topic is too complex with many unanswered questions.
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