What happens to the mRNA vaccine particle (Pfizer/Moderna) once it gets injected into your muscle? Short thread based on #TWiV 687. Thanks to @BioProfBarker for the explanation! (1/n)
microbe.tv/twiv/twiv-687/
microbe.tv/twiv/twiv-687/
There are two or three places where it can end up.
1. It can enter some local muscle cells. The vaccine mRNA is translated into protein inside those cells and that protein is recognized by immune cells are foreign, ultimately leading to production of antibodies and T cells. (2/
1. It can enter some local muscle cells. The vaccine mRNA is translated into protein inside those cells and that protein is recognized by immune cells are foreign, ultimately leading to production of antibodies and T cells. (2/
2. It can enter local dendritic cells, which are known as "professional antigen-presenting cells". As soon as the vaccine mRNA is translated into protein inside these cells, that protein will be recognized as foreign... (3/n)
and the dendritic cells will head to the lymph node, where they will present it on their surface to T cells of the immune system. (4/n)
3. It can enter local muscle cells, which immediately die due to the trauma caused by injection. Those dead muscle cells will then be swallowed by dendritic cells and the mRNA will then follow a similar path as described in 2) above. (end)
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