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Vincent Rajkumar Profile picture
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8 Dec, 6 tweets, 3 min read
Pfizer COVID Vaccine. Amazing! The numbers speak for themselves. I’m sure Moderna has similar numbers. One of the greatest achievements in medicine of all time. I’m all in. @ASlavitt Image
Here is the link to the full FDA briefing document. A lot it detail in here. fda.gov/media/144245/d…
And additional information here from @Craig_A_Spencer
I still all in.
Answers to some questions.
And the full @NEJM paper. Congrats on getting this out so quickly. @pfizer @BioNTech_Group

@DrEricDing Didn’t know your praise of Oxford vaccine Lancet paper would have such immediate effect!
nejm.org/doi/10.1056/NE…

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Vincent Rajkumar Profile picture
10 Dec
The way the immune system works is that specific immunity to anything (whether virus or bacteria; first infection or recurrence) will only kick in after the infection gets into you, & the innate (non specific) immune response cells presents the pathogen to your T and B cells
1/
So any vaccine, will only help you clear the pathogen quickly before it causes harm or disease. No vaccine can actually prevent the pathogen from entering the body in the first place. It can only help you clear the virus or bacteria quickly.

2/
So during the time span from when a virus enters the body and when it is cleared by the specific immune response, a person is at least theoretically infectious. But it will be much shorter time span if someone has pre-existing immunity from prior natural infection or vaccine
3/
Read 6 tweets
Vincent Rajkumar Profile picture
10 Dec
For people of the world, it doesn’t matter whether it’s Moderna or Pfizer or Oxford or SinoPharm: Just get whichever vaccine that’s available. That’s the simple message.

The sooner more people are vaccinated, the closer we are to herd immunity, & more lives saved. @DrEricDing
All this nitpicking and overstating the obvious caveats is not helpful.

From what I have seen all 4 vaccines work great. Just get them going. It’s a hundred times better than a day extra with this awful pandemic and the lives being lost.
Who is to say the two extra weeks various agencies take to review will save more lives than could have been saved by faster vaccination?

At nearly 3000 deaths a day in the US, you can do the risk benefit calculations and contemplate.
Read 5 tweets
Vincent Rajkumar Profile picture
9 Dec
Those wanting to install two Mac OS systems on the same computer: don’t install in two volumes on same APFS container. Every time I boot in High Sierra it’s corrupting the Big Sur volume, & I had to reinstall. Try installing on two separate partitions. #BigSur #macOS @Apple
@JeffBenjam @9to5mac I tried your method. All went well for 2 weeks as long as I didn’t try to boot from High Sierra. Yesterday I did that. HS gave some error message which people have reported. Sadly when I booted back into Big Sur got a message that I need to reinstall the OS.
I thought may be an accident reinstalled Big Sur and was up and running after the installation. But when I booted to High Sierra and tried to boot back, same error and had to reinstall Big Sur again.
Read 5 tweets
Vincent Rajkumar Profile picture
7 Dec
#ASH20 IFM 2009 trial results presented by @PerrotAurore

On intent to treat basis early and delayed stem cell transplantation led to identical overall survival at 8 years. Timely given the pandemic situation. See thread on what these results mean. #ASH20VR @ASH_hematology
Important to note that higher PFS,better MRD- with early transplant, and the fact that not everyone who was randomized to delayed transplant did not manage to affect the probability of staying alive at 8 years one bit. #ASH20

2/
Nevertheless, I still recommend early transplant for most eligible patients for reasons discussed in this thread.
Read 6 tweets
Vincent Rajkumar Profile picture
7 Dec
Daily COVID deaths in the US have just reached the same level as in April. Back then we can say we were caught unawares. Now we can’t.

A massive human tragedy. ig.ft.com/coronavirus-ch…
I don’t think you want to look at the same figure for daily new cases. It’s not only depressing. But terrifying.
Or the raw numbers.
Read 4 tweets
Vincent Rajkumar Profile picture
5 Dec
@sumanthraman @EricTopol This is a great question. I’ll try my best to answer.
1) First is that the question also applies to Europe which is doing just as bad as the US. So why are USA and Europe doing worse than more crowded and much poorer countries?
@sumanthraman @EricTopol 2) I think one of the most likely factors is that there must be some form of pre-existing cross reactive immunity which is helping keep the disease severity low. So more asymptomatic cases, and fewer hospitalizations and deaths. I did a thread on this a while back.
@sumanthraman @EricTopol 3) The second factor is certain favorable demographics in countries like India: age distribution (lower median age), and lower prevalence of obesity. A lot of severe COVID is associated with these two factors.
Read 7 tweets

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