One common question in recent days: How come places with mask mandates & restrictions have also been affected with high rates of COVID?

A few thoughts:

1) We are dealing with an enemy that doesn’t play fair. So unless there is high compliance, it exploits the weakest link.
2) Unfortunately masks are only one piece of the puzzle needed to stop COVID. They work in concert with other measures including border control, testing, tracing, ventilation, social distancing, protecting vulnerable populations etc. They work as part of a coordinated strategy.
3)Some places did do well for months. But then when they relaxed, the virus came right back. Until we have herd immunity from vaccines, the COVID virus does not magically disappear with just a few months of compliance. Needs to be sustained. Thankfully we have an end in sight.
4) Some places like Australia, and New Zealand implemented pretty strict border controls early on. This made it difficult for the virus to enter their countries from outside. They have then been able to relax restrictions because there is no COVID inside their borders to speak of
4) Once there are tens of thousands of cases of COVID within the borders it becomes hard to do control. Hard to screen borders after the fact. So we have to rely on preventing spread from within. This is where masks, distancing, testing etc come in.
5) When 9/11 happened we gave up a lot of freedoms. Some permanently.

COVID is causing 9/11 like death tolls everyday for months now. The freedoms we give up by wearing masks and social distancing is temporary. We already have vaccines. So it won’t be much longer.
6) I wish this was a pandemic that came with warning and spread slowly, so that we could do randomized trials and prove that masks work. Or that distancing works. We didn’t have that luxury. We had to go with best medical judgment & data. And we did have a lot of supporting data.
7) No one is going to be able to prove conclusively anything. But it is clear that countries that did everything aggressively from the start have suffered the least. You can call it luck. But they have peace of mind. Im sure they are happy to have “overreacted”.
Thanks for many replies. I’m linking to a thread I did before that highlights how transmission happens in small get togethers at home may be useful. 👇

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More from @VincentRK

15 Dec
What evidence did it take thalidomide, the most notorious drug of all time to be used by cancer doctors in the US?

A study of 84 patients with no control arm. Myeloma cancer occurs in about 4/100,000 people per year. And had a median survival of 3-4 years at that time.
1/
This is that study.

84 patients of whom 25% responded to therapy. Published in 1999. @NEJM nejm.org/doi/full/10.10…
I led a randomized trial which eventually got thalidomide FDA approved for myeloma in 2006, but that trial would not be published until 2005.

By then thalidomide was already used widely in the US, off label, almost exclusively for myeloma. @ASCO_pubs ascopubs.org/doi/10.1200/JC…
Read 5 tweets
15 Dec
Moderna Vaccine. The numbers speak for themselves as well. Deja vu.

As I said with the Pfizer vaccine: One of the greatest achievements in medicine of all time. We are grateful. @ASlavitt
Link to the full FDA briefing comment. fda.gov/media/144434/d…
Here is the primary efficacy table for the Pfizer vaccine. And link to the FDA briefing document. fda.gov/media/144245/d…
Read 8 tweets
13 Dec
When COVID vaccines are available, should adult patients with cancer or on chemotherapy get the vaccine?

My opinion: Yes
I posted this because I had many inquiries on DM. If further questions please DM.
Reply to FAQ on DM.

There is no reason not to give the COVID vaccine from a safety standpoint to patients with cancer. In some patients with advanced cancer the vaccine may not work as well. But that is still better than no vaccine.
Read 4 tweets
10 Dec
The way the immune system works is that specific immunity to anything (whether virus or bacteria; first infection or recurrence) will only kick in after the infection gets into you, & the innate (non specific) immune response cells presents the pathogen to your T and B cells
1/
So any vaccine, will only help you clear the pathogen quickly before it causes harm or disease. No vaccine can actually prevent the pathogen from entering the body in the first place. It can only help you clear the virus or bacteria quickly.

2/
So during the time span from when a virus enters the body and when it is cleared by the specific immune response, a person is at least theoretically infectious. But it will be much shorter time span if someone has pre-existing immunity from prior natural infection or vaccine
3/
Read 6 tweets
10 Dec
For people of the world, it doesn’t matter whether it’s Moderna or Pfizer or Oxford or SinoPharm: Just get whichever vaccine that’s available. That’s the simple message.

The sooner more people are vaccinated, the closer we are to herd immunity, & more lives saved. @DrEricDing
All this nitpicking and overstating the obvious caveats is not helpful.

From what I have seen all 4 vaccines work great. Just get them going. It’s a hundred times better than a day extra with this awful pandemic and the lives being lost.
Who is to say the two extra weeks various agencies take to review will save more lives than could have been saved by faster vaccination?

At nearly 3000 deaths a day in the US, you can do the risk benefit calculations and contemplate.
Read 5 tweets
9 Dec
Those wanting to install two Mac OS systems on the same computer: don’t install in two volumes on same APFS container. Every time I boot in High Sierra it’s corrupting the Big Sur volume, & I had to reinstall. Try installing on two separate partitions. #BigSur #macOS @Apple
@JeffBenjam @9to5mac I tried your method. All went well for 2 weeks as long as I didn’t try to boot from High Sierra. Yesterday I did that. HS gave some error message which people have reported. Sadly when I booted back into Big Sur got a message that I need to reinstall the OS.
I thought may be an accident reinstalled Big Sur and was up and running after the installation. But when I booted to High Sierra and tried to boot back, same error and had to reinstall Big Sur again.
Read 5 tweets

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