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Vincent Rajkumar Profile picture
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15 Dec, 8 tweets, 3 min read
Moderna Vaccine. The numbers speak for themselves as well. Deja vu.

As I said with the Pfizer vaccine: One of the greatest achievements in medicine of all time. We are grateful. @ASlavitt
Link to the full FDA briefing comment. fda.gov/media/144434/d…
Here is the primary efficacy table for the Pfizer vaccine. And link to the FDA briefing document. fda.gov/media/144245/d…
The efficacy curves for the Pfizer/BioNTech and Moderna vaccines looks very similar. Outstanding efficacy.
Independent FDA panel meets Thursday, Dec 17 to review the Moderna vaccine. Hopefully we have a swift EUA.
Here is the Final analysis Table. Of note, Highly effective in people over 65: 4 cases vs 29 cases. (86.4% efficacy)

Importantly the vaccine was 100% effective in preventing severe COVID.

0 cases in Vaccine group vs 30 in placebo group.
Vaccines provide the immune system with the target that they had not encountered before. So when COVID virus meets the immune system, the body is more prepared. Which is why I believe vaccines will be even more effective in preventing severe disease. Glad with Moderna results.
Link to prior thread on Pfizer BioNTech vaccine results.

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More from @VincentRK

Vincent Rajkumar Profile picture
13 Dec
When COVID vaccines are available, should adult patients with cancer or on chemotherapy get the vaccine?

My opinion: Yes
I posted this because I had many inquiries on DM. If further questions please DM.
Reply to FAQ on DM.

There is no reason not to give the COVID vaccine from a safety standpoint to patients with cancer. In some patients with advanced cancer the vaccine may not work as well. But that is still better than no vaccine.
Read 4 tweets
Vincent Rajkumar Profile picture
10 Dec
The way the immune system works is that specific immunity to anything (whether virus or bacteria; first infection or recurrence) will only kick in after the infection gets into you, & the innate (non specific) immune response cells presents the pathogen to your T and B cells
1/
So any vaccine, will only help you clear the pathogen quickly before it causes harm or disease. No vaccine can actually prevent the pathogen from entering the body in the first place. It can only help you clear the virus or bacteria quickly.

2/
So during the time span from when a virus enters the body and when it is cleared by the specific immune response, a person is at least theoretically infectious. But it will be much shorter time span if someone has pre-existing immunity from prior natural infection or vaccine
3/
Read 6 tweets
Vincent Rajkumar Profile picture
10 Dec
For people of the world, it doesn’t matter whether it’s Moderna or Pfizer or Oxford or SinoPharm: Just get whichever vaccine that’s available. That’s the simple message.

The sooner more people are vaccinated, the closer we are to herd immunity, & more lives saved. @DrEricDing
All this nitpicking and overstating the obvious caveats is not helpful.

From what I have seen all 4 vaccines work great. Just get them going. It’s a hundred times better than a day extra with this awful pandemic and the lives being lost.
Who is to say the two extra weeks various agencies take to review will save more lives than could have been saved by faster vaccination?

At nearly 3000 deaths a day in the US, you can do the risk benefit calculations and contemplate.
Read 5 tweets
Vincent Rajkumar Profile picture
9 Dec
Those wanting to install two Mac OS systems on the same computer: don’t install in two volumes on same APFS container. Every time I boot in High Sierra it’s corrupting the Big Sur volume, & I had to reinstall. Try installing on two separate partitions. #BigSur #macOS @Apple
@JeffBenjam @9to5mac I tried your method. All went well for 2 weeks as long as I didn’t try to boot from High Sierra. Yesterday I did that. HS gave some error message which people have reported. Sadly when I booted back into Big Sur got a message that I need to reinstall the OS.
I thought may be an accident reinstalled Big Sur and was up and running after the installation. But when I booted to High Sierra and tried to boot back, same error and had to reinstall Big Sur again.
Read 5 tweets
Vincent Rajkumar Profile picture
8 Dec
Pfizer COVID Vaccine. Amazing! The numbers speak for themselves. I’m sure Moderna has similar numbers. One of the greatest achievements in medicine of all time. I’m all in. @ASlavitt Image
Here is the link to the full FDA briefing document. A lot it detail in here. fda.gov/media/144245/d…
And additional information here from @Craig_A_Spencer
Read 6 tweets
Vincent Rajkumar Profile picture
7 Dec
#ASH20 IFM 2009 trial results presented by @PerrotAurore

On intent to treat basis early and delayed stem cell transplantation led to identical overall survival at 8 years. Timely given the pandemic situation. See thread on what these results mean. #ASH20VR @ASH_hematology
Important to note that higher PFS,better MRD- with early transplant, and the fact that not everyone who was randomized to delayed transplant did not manage to affect the probability of staying alive at 8 years one bit. #ASH20

2/
Nevertheless, I still recommend early transplant for most eligible patients for reasons discussed in this thread.
Read 6 tweets

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