1/ THIS was an email sent 9yrs ago—from an unknown scientist with entrepreneurial ambitions.

We didn’t reply

9yrs later we + others (including Bill Gates, Jim Simons , sovereign wealth funds + top biotech VCs)—have put over $250M in companies @ipeikon has helped start with Lux
2/ Here is the story of KALLYOPE—which this brilliant young scientist helped create + build with Lux’s @AGoulburn leading the way.
3/ HERE was one of the founding dinners—

where Columbia U’s Tom Maniatis (to my right) tipped off Lux me + @AGoulburn
to the enormous potential of Cryo-EM as cutting edge technology for science...
4/ Sneak peak inside the Kallyope BoD room with @AGoulburn
5/ Here are some excerpts from exclusive Lux series—

explaining the science + tech + people behind Kallyope...

“The gut-brain axis is the bi-directional communication between the gut + the brain. It’s composed of neural circuits + hormonal circuits...”
6/ The brilliant @ThornberryNancy explaining the science + tech of cutting edge venture: Kallyope.

“We’re leveraging a # of advanced technologies—to create a comprehensive map of gut-brain circuits: single-cell sequencing, organoids, optogenetics, chemogenetics...”
7/ “There’s no question that important aspects of physiology are mediated by the gut-brain axis—there’s a biochemical basis for things like a GUT FEELING, for example.”

“In the same way that I might sit down at a piano and hit a note and it produces a sound or a chord...
8/ “In the same way that I might sit down at a piano and hit a note and it produces a sound or a chord...and it produces a different sounds, the idea is that if you can use gut-restricted molecules, that you are basically targeting different notes that you can play in the brain.”
9/ Especially RELEVANT in light of recent news...

wsj.com/articles/depre…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Josh Wolfe

Josh Wolfe Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @wolfejosh

15 Dec
1/ The VISUAL is VISCERAL

Was telling my 10yo daughter why we both cry more easily in movies than books—empathy, emulation, mirror neurons (maybe).

Few looked at Syria (statistics, words on pages)
til powerful pic of tragic toddler washed ashore
made it too hard to look away...
2/ A few 2020 year of pictures—

all powerful with context we have
that someone from the past would not grok
nor someone in the future without knowing history.

Dallas Morning News...
dallasnews.com/news/2020/12/1…
3/ SF Chronicle 125 pics for 2020

sfchronicle.com/projects/2020/…
Read 12 tweets
5 Dec
1/ As we approach the end of 2020–
a REMINDER of the power of RESILIENCE.

When things seem like total disasters—politics, poverty, pandemic—it is because of REALISM that they are...

...which gives way to conditional OPTIMISM that our globally interconnected, market-driven...
2/...highly competitive whether

-in SCIENCE via methods of conjecture + refutation

-in PRODUCTS via better, cheaper, faster, more convenient

-in INVESTORS in self-interest competing to be earlier than others, funneling funds MOST likely to be lost for slim chance of big gains
3/ Which have driven

-global communication costs to near ZERO
-processor computation + video rendering to exponentially better quality
-frictionless exchange of scientific information to model in DAYS(!) + manufacture in MONTHS(!) a vaccine
-with a system of safety + testing...
Read 5 tweets
3 Dec
1/ Why not cancel it all? Free everything!

Cancel construction workers + supers + electricians + painters + HVAC workers + gardeners + decorators

We can cancel taxes too (they come from people with jobs making + spending $)––then cancel politicians salaries paid for by taxes
2/ Cancel monthly bills for cable + phones + internet + gym memberships + magazines + newspapers + substack subscriptions!

And cancel restaurants too––
food + fun should be free for all!
3/ Cancel car payments + cancel airline tickets––travel should be free for everyone.

Cancel music subscription services + podcasts.
Cancel Spotify + Apple.
Cancel royalties to artists.
No 1 artist should be more popular than the 99%!
Cancel ticket sales to concerts + sports.
Read 6 tweets
3 Dec
1/ SCI-FI <> SCI-FACT🤯

Like Star-Wars—your first personal holographic display has arrived.

Meet “Looking Glass Portrait”.
Designed for people, real––and imagined.

Radically priced @ $199
today + tomorrow only.
Pre-order look.glass/portrait
2/ When @chrisfralic thought to introduce me to @LKGGlass––i remember we spoke about the directional arrow of progress

We had to take risk to believe resolution would keep evolving (just as YouTube went from 240 > 360 > 720 > 1080p > 4k)...

The PROGRESS + PROGRESSION amazes.
3/ Look at the progress from this video of ~3 years ago...
Read 4 tweets
30 Nov
1/ SOME NEWS

The charter school that I co-founded + Chair in my native Coney Island, Brooklyn––has sued the CDC + Trump administration.

Our scholars + families demand reliable information and government competence.

The @NewYorker just covered it.
newyorker.com/magazine/2020/…
2/ Part 1...
3/ Part 2...

From @ciprep CEO Leslie-Bernard Joseph:

"It's like trying to swim against the current of the Pacific Ocean. We knew we were drowning, and we were just going to try to keep swimming as long as we could"
Read 6 tweets
25 Nov
My 2020 rap faves

RTJ4
Jay Electronica—written testimony + act 2
Aesop Rock—spirit world field guide
unlocked—denzel curry x kenny beats
Marlowe 2
Eminem—Music to be..
Alfredo—alchemist
Revenge of the Dreamers
Clams Casino—esp ‘unchain me’; Lost Boys🎥
Pray for Paris
Marlowe 2
2/ A fave track of all of this––is this “DIET_”

GENIUS lyrics—and a hook with an amazing ascendant 3 bar rhyme that is an exorcism of DMX to a rising Slick Rick bassline

when you hear it you will hear it
(if you don’t it’s @ 0:47)
open.spotify.com/track/1AzqpMy3…
3/ the Clams Casino instrumental is solid but this track is more personal, he samples Cry Little Sister from “Lost Boys”—i was 9 and in middle of cross-country custody battle and LOVED this movie and well––wanted to be a vampire in Kiefer Sutherland’s gang
open.spotify.com/track/0RokJnY3…
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!