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Dr. Ali Nouri Profile picture
@AliNouriPhD
Dec 24, 2020 • 4 tweets • 3 min read • Read on X
1/📌Evidence of #Airborne #SARSCoV2 traveling 12 floors of an apt building through the drainage system: 200+ residents in a wing of a high-rise were tested, revealing 9 infections. Those families lived in 3 vertically aligned flats connected by drainage pipes in the bathrooms🧵 Image
2/To confirm apt units are indeed connected, tracer gas was released into drainage system of one unit and shown to come out of the other. Evidence for alternative mechanisms of transmission (e.g. use of public spaces, elevators, etc..) could not be found. Image
3/Plausible scenario is infection through drainage system. While U-traps typically act as water seals in each bathroom's drainage system, if unused, they can dry out, allowing aerosols from one unit to travel to another.
Report: ncbi.nlm.nih.gov/pmc/articles/P… ImageImage
4/A separate study has also implicated the transmission of SARS-CoV-2 through the air ducts of a building in South Korea:

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More from @AliNouriPhD

Dr. Ali Nouri Profile picture
Aug 27
1/New study on how Clade 2b Mpox spreads between people👇

Note: this is a different clade (subtype) from more recent outbreak caused by Clade 1b which is more lethal (more on clade 1b later)

Now back to Clade 2b: from 2022-24 it spread to >100 nations
wwwnc.cdc.gov/eid/article/30…
2/The outbreak was driven by human-to-human transmission via close contact with infected persons; most cases among men who have sex with men.

However: the new study (albeit small sample size) points to infection from contact with skin lesions as higher risk than from semen.
3/Researchers looked at Mpox G2R-mRNA activity which is an indicator of replicating virus. They found high activity (more virus replication) in lesions, but much lower activity (in some cases non existent) in semen, suggesting that this biologic fluid could represent minor route.
Read 5 tweets
Dr. Ali Nouri Profile picture
Nov 6, 2022
According to CDC 1 out of 5 who are infected with SARS-COV-2 develop Long Covid.

New report by @zalaly using @DeptVetAffairs data found taking Paxlovid is associated with a 25% decrease in #LongCovid: rb.gy/vnwitj

A thread on how Paxlovid💊neutralizes the virus👇 1/5
2/The SARS-CoV-2 virus is made up of components (proteins, RNA, lipids) that come together and give rise to functional virus particles. Paxlovid blocks the ability of some of the proteins to function, resulting in a defective virus. Here's how…
3/Normally, when the virus infects cells, its RNA genome replicates, the RNA is turned into proteins, & proteins come together to make new viruses.

When the proteins are made, they're  initially strung together, but they need to be freed from one another in order to do their job
Read 5 tweets
Dr. Ali Nouri Profile picture
Oct 31, 2022
Big news from @ENERGY:

Electric Vehicle battery & grid battery supply chains are coming to the USA 🇺🇸

$2.8 Billion in awards to support 20 companies to manufacture domestically

This is 1st of set of investments to build out battery manufacturing

A thread on projects👇1/22
2/22

Albemarle: project objective to construct new, commercial-scale U.S.-
based lithium materials processing plant at Kings Mountain, North
Carolina that uses sustainably extracted minerals from the site’s lithium mine.
3/22

American Battery Technology Company: commercial-scale facility to manufacture battery cathode lithium hydroxide from Nevada-based lithium-bearing sedimentary resources.
Read 22 tweets
Dr. Ali Nouri Profile picture
Aug 15, 2022
The Inflation Reduction Act Congress just passed includes a historic $369 billion investment to 1) lower energy costs; 2) revitalize US manufacturing; 3) slash greenhouse gasses by 40%; and 4) address environmental justice. Here are a few highlights from this bill🧵 Princeton REPEAT Project
1. Lowers energy costs for consumers:

Includes rebates to install electric & low emission appliances in homes

Also includes tax credits to make homes energy efficient, install solar, geothermal, etc...

$7,500 consumer credit to purchase clean cars like EVs; $4K for used🚘
2. Supports nationwide clean energy manufacturing base

Tax credits for manufacturers of clean energy technologies

Grants and loans so auto makers can retool & produce clean cars, like Electric Vehicles

Funds R&D @ENERGY National Labs to develop next-gen energy technologies
Read 6 tweets
Dr. Ali Nouri Profile picture
Jul 18, 2022
1/Early diagnosis, isolation & contact tracing of close contacts are key to controling the Monkeypox outbreak.

Here are the European Union health authority's recommendations for who should be contact traced during this outbreak: the four categories of "close contacts" include:🧵 Image
2/
🔹️Sexual partners: those with any type of sexual contact with MPX cases from the onset of symptoms

🔹️Household contacts: those living in same household (inc. overnight camping/stay) with MPX cases; those sharing clothing, bedding, utensils; or caregivers of MPX cases Image
3/
🔹️Health workers coming into contact w/patient's lesions or w/prolonged face-to-face contact (>3 hrs at < 2m distance) or involved w/aerosol generating procedures—all without PPE

🔹️Other: case-by-case, may include those sitting next to MPX case during prolonged travel Image
Read 4 tweets
Dr. Ali Nouri Profile picture
Jul 9, 2022
1/Monkeypox is a member of the Poxviridae family. These are large viruses with large DNA genomes (∼200 thousand bases🧬). By comparison, sars-cov-2 has ~30 thousand. And since its genome is made of RNA it mutates more than monkeypox. Nice review article:rb.gy/higk98🧵
2/Monkeypox is closely related to the infamous smallpox. After smallpox was eradicated through a global vaccination campaign we rightly stopped vaccinating against it. But that allowed monkeypox, once confined to remote areas, to spread more.
3/While the monkeypox case fatality is lower than smallpox—which had a whopping 30% case fatality—monkeypox is quite serious and lethal. Historically the Central African clade had a 10.6% fatality, while the West African clade was 3.6%. The latter has spread around the world.
Read 5 tweets

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