Discover and read the best of Twitter Threads about #SARSCoV2

Most recents (24)

Concerning—The coronavirus can remain on some surfaces for 28 days, including phone screens, paper money, & stainless steel, according to a new study. Around room temp of 68 degrees F, #SARSCoV2 could last for 28 days on smooth surfaces. 🧵 #COVID19
webmd.com/lung/news/2020…
2) “The study also found that the virus survived longer at lower temperatures and tended to last longer on non-porous or smooth surfaces such as glass and stainless steel rather than porous or rough surfaces such as cotton.”
3) “At higher temperatures, the survival time decreased as the temperature increased, and on cotton, the virus wasn’t detectable after 14 days.
However, the study was conducted in the dark to remove the effect of UV light, which can inactivate the virus.
Read 4 tweets
(1/5) Study showing that school closures were associated with a marked reduction in the common cold in adults in the UK.

When schools reopened, rhinovirus detections surged. Physical distancing measures in schools are inadequate to prevent transmission.
thelancet.com/journals/lanre… Image
(2/5) In this study, patients admitted to hospital between March and September 2020 in Southampton were screened for rhinovirus.

The results were compared against data for 2019.

There was a marked decrease in rhinovirus in 2020, which was associated with school closures.
(3/5) When schools reopened, rhinovirus infections in adults increased, and became comparable to the previous year.

This suggests children are a major driver of the common cold, and that #COVID19 precautions in schools are inadequate to prevent transmission of rhinovirus.
Read 5 tweets
1/ THREAD: I’m obsessed with the eyes, brains, GABA, autopsies & #COVID19

Periodic reminder that I think too much and ask too many questions, and if that bothers you, I would not recommend following me!

Anywho, lots of thoughts percolating tonight...yay insomnia 🧪👩🏾‍🔬🧠🔬 👁️🦠🙃
2/ I've already written too many threads on eyeballs and #COVID19, so I'll spare you redundancy. Here was my most recent one:

The eye and a new paper re: #SARSCoV2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With COVID19
3/ So Brains...🧠

I was thinking more about that AMAZING German autopsy study in @TheLancetNeuro and how they found #SARSCoV2 by IHC in the cranial nerves [either the glossopharyngeal or vagal nerves] originating from the brainstem! #COVID19

thelancet.com/journals/laneu… Image
Read 21 tweets
Thread "conspirationniste" : et si le virus #SARSCoV2 n'était pas "bio", pas d'origine 100% naturelle ? 🤨

Jusqu'à présent, la quasi-totalité des virologistes ont assez rapidement balayé cette hypothèse parce que le #coronavirus a "l'air naturel", à leurs yeux.

MAIS :

⬇️
Il existe au moins un précédent CONNU de virus "probablement échappé d'un labo", c'est le virus influenza A/H1N1(grippe) de 1977 : il ressemble un peu trop au virus de A/H1N1 de 1950 pour que ça puisse être naturel.

virology.ws/2009/03/02/ori…

⬇️
Dans l'article précité, @profvrr (Vincent Racaniello) rappelle ce virus de 1950 réapparu en 1977 à propos de la fameuse pandémie de "grippe porcine". Or, le virus de 2009 est un virus réassorti avec au moins trois virus parents étonnants, difficile à expliquer naturellement :
⬇️
Read 22 tweets
Back in April, @c_drosten told me that investigations into #covid19 origin should also look at farmed raccoon dogs in China as possible intermediate hosts. Now, German scientists have made the first step, showing the animals can get and transmit #SARSCoV2. wwwnc.cdc.gov/eid/article/26…
@c_drosten "Our results indicate that affected farms might be reservoirs for #SARSCoV2. Thus, efficient and continuous surveillance should target susceptible animals, including raccoon dogs, especially in China, which is a key player in global fur production."
@c_drosten "We also need to initiate large-scale epidemiologic field studies with historic samples that might elucidate the role of farmed animals in the current pandemic."
Read 3 tweets
WHY MASK MANDATES ARE WRONG: I am in the 20% who had SARSCoV2. I wear a mask. I encounter SARSCoV2 & it's so small millions of miniscule virus parts are deposited on my mask by aerosols or touching. I breathe out through the mask filter: I AM NOW AN IMMUNE SPREADER! 🚫😷
By early May, 17.5% of the population of London had antibodies to SARSCov2. Cross reactive T cell immunity is probably at least twice as widespread.
gov.uk/government/pub…
If antibodies to SARSCoV2 were at 17.5% levels in May 5 months into the pandemic, what are they now 5 months later? If you find out please let me know. Let's guess:
Read 4 tweets
1/ THREAD: #SARS_CoV_2, #COVID__19, genetics, & HLA

Individual genetic variability in Human Leukocyte Antigen (HLA) genes in the major histocompatibility complex (MHC – 6p21.3) in humans have the potential to affect susceptibility to and severity of the diseases.
#FridayThoughts Image
2/ As the main drivers of our innate immune response, genetic variation in HLA complex may help explain different immune responses to a virus across a population. HLA alleles are critical components of the viral antigen presentation pathway.

nature.com/articles/s4141…
3/ These genes code for proteins on the surfaces of cells that send signals to the immune system, & differences in these signals can cause different reactions by the immune to invading pathogens.

ncbi.nlm.nih.gov/pmc/articles/P…

frontiersin.org/articles/10.33…
Read 31 tweets
Un resumen científico de la última semana sobre el #SARSCoV2 y la #COVID19. Un conjunto de evidencias y anécdotas variadas para estar informados, científicamente hablando, de la pandemia. Siempre queda mucho más, pero en este hilo os acerco algunas noticias importantes.
1. COVID19 EN JÓVENES
211 pacientes jóvenes (edad media: 44 años) recuperados de COVID19 y con baja co-morbilidad. Secuelas:
Fatiga (98%)
Dolor muscular (88%)
Problemas para respirar (87%)
Dolor de cabeza (83%),
2. COVID19 larga
Un extenso artículo sobre las secuelas de la COVID19. Con especial énfasis en los daños neurológicos, algunos de los cuales como la confusión y los dolores de cabeza pueden persistir meses. washingtonpost.com/health/covid-l…
Read 13 tweets
L'épidémie de #Covid_19 pour un infirmier libéral, c'est quoi?

Thread.
⬇️⬇️⬇️
Depuis le début de cette année nous vivons une situation très particulière. Difficile, éprouvante, l'épidémie impacte chacun d'entre nous.

Menace Depuis décembre 2019, réalité depuis février 2020 chez nous.
Nous sommes en février. Personne ne peut plus nier la réalité, le #SARSCoV2 est la. Dans l'ouest, chez moi, il s'agit d'écouter ce que vivent les collègues de l'est. Et c'est terrifiant.
Nous en savons alors très peu. Les modes de contamination possibles sont obscurs.
Read 19 tweets
A l'issue de cette journée du 22/10, il y a 41 622 nouveaux cas de #COVID19france (3e rang dans le classement mondial après les États-Unis et l'Inde qui ont respectivement 57 079 et 54 482 nouveaux cas ce jour). ⤵️
1,53 % de la population en France a été contaminé par #SARSCoV2.
Depuis le début de l'épidémie, 3,4 % des personnes atteintes par la maladie sont décédées.
Le nombre de cas total atteint désormais le nombre de 999 043.
Read 5 tweets
Illustre Prof.ssa @sandrasavaglio,la diffusione di #COVID19 registra una drammatico cambio di passo anche in #Calabria e i contagi aumentano in modo preoccupante:gli ospedali regionali sono già in grandissimo affanno e urgono misure efficaci (1/8)

(grafici by @Antonio_Caramia👇)
Nel contesto epidemico che sta attraversando la nostra Regione diventa estremamente delicato il tema #scuola. E' ormai accertata la trasmissione aerea di #SARSCoV2,per cui linee guida #CTS NON SONO ADEGUATE a rendere le aule scolastiche sicure (2/8)
👇
thelancet.com/journals/lance…
La distanza di 1 metro tra rime buccali indicata dal #CTS, a cui è consentito togliere la mascherina,è del tutto inadeguata a mitigare il rischio di contrarre #COVID19; oltretutto in assenza di areazione ADEGUATA l'aria si satura di particelle (3/8)

👇
bmj.com/content/370/bm…
Read 8 tweets
Am I living in bizarro world?!

🧵 So..US POTUS & Senate have refused to give K-12 schools $$$ for #SARSCoV2 testing for school safety: “You’re on yr own!” 🤯

So district in big Democratic city comes up w $$$ itself to do spot testing with parental consent (hats off, NYC!)..1/
So THEN someone in our “You’re on yr own” US executive says, “Actually I do have some thoughts!”

and bullies the actual *CDC* (the home of elite force of disease detectives who live to identify and squash outbreaks) into saying...2/
“Hey school districts, in case you were thinking about doing the extraordinary & forward-thinking work of standing up a whole #SARSCoV2 surveillance system in your K-12 schools bc yr federal govt has abandoned you...3/
Read 8 tweets
Time to share some thoughts and questions following the .@medrxivpreprint first release of results from the #SolidarityTrial that compared local standard care to #remdesivir, #HydroxyChloroquine #lopinavir_ritonavir and #interferon for treatment of patients with #COVID19
I have read the #solidarityTrial preprint: medrxiv.org/content/10.110…

Its supplementary material:medrxiv.org/content/10.110…

its posted protocol: who.int/publications/m…

The CRF: who.int/publications/i…

The final report from #ACTT1 for contrast: nejm.org/doi/full/10.10…
Everyone has focused on the results, which is understandable, yet understanding the specifics in #SolidarityTrial design compared to the #ACTT1 design, may bring light into the differences reported between trials and may give a way to do better in #COVID19 #therapeutics
Read 26 tweets
1/ Remember in April when @washingtonpost accidentally did some investigative reporting and revealed the State Department had worried about the very Wuhan lab from which the virus DEFINITELY DIDN'T ESCAPE in 2018, long before it DEFINITELY DIDN'T ESCAPE?
washingtonpost.com/opinions/2020/…
2/ And then scientists and reporters were like, oh, even though it would be bad for Chyyyna and make @realDonaldTrump super-duper happy, this is just one coincidence too many and it makes the theory that #sarscov2 went bat-civet-human BECAUSE SCIENCE even stupider?
3/ And then @nytimes @washingtonpost and other top outlets decided to investigate and @nature and other top journals did too, because the issue of the origins of #sarscov2 was just too important to allow the Chinese to steamroll the world? Even if the Orange Man would be pleased?
Read 5 tweets
Leider gibt es noch keine Stellungnahme des @ethikrat, ob die Durchsetzung der Schulpflicht während der #Pandemie dem allg. Lebensrisiko zu rechtfertigen ist. Ich habe mir die Stellungnahme Impfen als Pflicht angeschaut. Darin heißt es auf S. 49 Image
In der Zusammenfassung unter Punkt 4
Könnte man ähnlich auch auf #COVID19 anwenden. Image
Zusammenfassung Punkt 12
"das Grundrecht des Kindes auf Gesundheit und körperliche Unversehrtheit..." Image
Read 10 tweets
Cuando trabajas con niños te das cuenta de una cosa estupenda: tienden a la salud.
Gracias a diagnósticos precoces tras el nacimiento, mayor conocimiento de enfermedades, seguimiento de su desarrollo, uso de vacunas... la mayoría de los niños están sanos.
Y eso se puede utilizar.
Los niños son la mejor población para meter el cazo.
Puedes vender a los padres movidas que no aportan porque los padres siempre querrán lo mejor para sus hijos.
Objetos.
Libros.
Y, por supuesto, cosas que van de terapias pero dan dinerito.
Los críos son un win-win.
Toma este jarabe.
Mira estas gotas.
Este stick si se golpea.
Que no mire al este.
Dale estas vitaminas para subir las defensas.
Como están sanos o lo que les pasa se resolverá sin hacer nada son un target “crema”.
Read 15 tweets
(1/6) A new pre-print study (interpret carefully) describes *in vitro* evidence of antibody dependent enhancement (ADE) after natural infection with #SARSCoV2 in some people. ADE is when antibodies make a second infection worse.
scmp.com/news/china/sci…
(2/6) If ADE occurs, it is most likely to happen late after recovery when levels of neutralising antibodies have waned.

Here’s the actual study:
medrxiv.org/content/10.110…
(3/6) This review describes what ADE is, how it can occur, and what we know about ADE and other coronaviruses so far.

There is no evidence of ADE occurring with any #COVID19 vaccine under development yet.
stm.sciencemag.org/content/early/…
Read 6 tweets
Feels like it might happen again, doesn't it?

I'm not saying Trump will win - he dug himself a huge hole, and this time the media ex-Fox is so deeply in the tank for @joebiden they're actively suppressing news (not covering the legitimate issues in the Hunter Biden emails?)...
But the rallies are real. The early voting data is real. And most importantly @realDonaldTrump has turned into a walking, talking middle finger to the idea that #sarscov2 is the end of the world. And lots and lots of people are ready for the new normal to be old normal....
They are sick of school closings. Sick of signs telling them to wear masks. Sick of being told Thanksgiving is a health hazard. They aren't at home on Zoom calls, they are going to Wal-Mart for groceries, and THEY ARE DONE WITH THE RO.

And so is @realDonaldTrump.

We will see.
Read 3 tweets
My 2-year-old loves swings. His favorite playground finally opened, but all the swings have been removed.
SF reopened indoor dining before playgrounds.
And indoor dining is limited to 2 hours, while playing at a playground is limited to 30 minutes. bit.ly/2IEDWeg 🧵
When considering the differential in risk of transmission, this is backwards.
As a parent of 2 toddlers who went through their snotty-nosed years, I get it. Kids in general-and playgrounds in particular-are often associated w/ germs. But #SARSCoV2 is different. (2)
While the risk of transmission outdoors isn’t always zero, it’s likely many orders of magnitude (~20) lower than the risk of transmission indoors, especially when combined w/ masks. (Oddly, it’s harder for me to get my kids to wear shoes than masks.) (3)
medrxiv.org/content/10.110…
Read 8 tweets
🔥Une ressource incroyable sur #COVID19 #SARSCoV2 développée par #COREB @REACTing_fr @hopitalbichat

130 diapositives qui font le tour de la littérature scientifique COVID !
Voilà quelques "highlights" dans ce thread mais allez sur le lien pour le reste :
coreb.infectiologie.com/UserFiles/File…
Au programme
- Epidémiologie
- Virologie
- Clinique
- Thérapeutique
De nombreux articles montrant la possibilité de transmission par des patients asymptomatiques ou 2/3 jours avant début des symptômes.

Après 7 jours, bcp moins de risques de transmission.
Read 18 tweets
1/ Last week @mlipsitch - a Harvard epidemiologist - wrote a blistering @washingtonpost piece attacking any plan for herd immunity. Letting people at low risk for #Covid become infected “could kill millions,” he and other authors argued, because older people will also get sick...
2/ Now Lipsitch is smart, well-respected - a top public health expert. We should take what he says seriously.

But we all know #Covid has been deeply politicized. Which is why this piece from him in 2008 - before #sarscov2 was a gleam in a Chinese bat’s eye - is so fascinating...
3/ It’s called “Too Little Of A Good Thing: A Paradox Of Moderate Infection Control.” In it, @mlipsitch makes a persuasive case that for illnesses that are likely to spread widely, efforts to protect people at low risk will be COUNTERPRODUCTIVE. Why?
Read 5 tweets
BREAKING—China CDC confirms the isolation of active #SARSCoV2 coronavirus from outer packaging of imported frozen cod in city of Qingdao. First time proven that **contact w/ frozen packaging w/ active novel coronavirus could lead to infection**. Worrisome. xinhuanet.com/english/2020-1…
2) “The agency said that the risk of cold-chain food circulating in China's market being contaminated by the novel coronavirus is very low, citing recent nucleic acid test results for samples taken from the business.”
3) “A total of 2.98 mil samples had been tested across 24 provinces by Sept. 15, including 670k taken from cold-chain food & packaging, 1.24 mil from working staff and 1.07 mil from environment. Only 22 samples from cold-chain food or food packaging tested positive for the virus”
Read 7 tweets
𝟏 A 🧵 on:
🔸 Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) currently used to detect #SARSCoV2

🔸Cycle Threshold (CT) & what it means

#scicomm #COVID19
𝟐 RT-qPCR is a common lab technique used to convert RNA to DNA & quantify its amount.

DNA & RNA are two forms of genetic material: DNA is like the mother code, while the RNA is a transcribed copy of (often) a segment of this mother code.
𝟑 #COVID19 virus contains this transcribed form (RNA) wrapped in a protective protein capsule
To detect its presence in cells we collect a swab from a person suspected to be infected w/ the virus.
Note: swab will contain human, viral & other microbes’ particles
Read 16 tweets
People are talking about *forward* and *backward* #ContactTracing #COVID19

What do they mean?

I made a case study for the @GOARN @WHO contact tracing group

A fictional contact tracer’s tale

My slides are here:
ispmbern.github.io/covid-19/Forwa…

Short thread (1/7) Forward and backward contact tracing for COVID-19, slideshow
Most #ContactTracing seeks contacts from 2 days before the infected person developed symptoms

#SARSCoV2 can be transmitted before symptoms emerge.
That is looking *forwards*

Who might the index case have infected?

Contacts in quarantine soon enough won’t infect others

2/7
Forward contact tracing can break onward transmission chains.

But it doesn’t find the source who infected the index case

To find the source, we need to go *backwards*

Index cases are more likely to have been infected by a source, who also infected others in a cluster

3/7
Read 7 tweets

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