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Eric Feigl-Ding Profile picture
@DrEricDing
Dec 27, 2020 • 10 tweets • 5 min read • Read on X
BREAKING—95%—new data from Oxford/AstraZeneca vaccine shows 95% efficacy & is “100% effective” in preventing severe 🏥illness, says AZ CEO. That’s on par w/ Moderna & Pfizer. No official data yet, but UK 🇬🇧 said to likely approve in days. HUGE🧵. #COVID19
thetimes.co.uk/article/covid-… Image
2) As u know, Oxford was unhappy with the last trial because of the dosing quirk with the half dose / full dose issue that led to a split finding of 90% in the half-full dose, but 63% in the full-full dose. Hence they said last month they will redo with a new trial.
3) Recall the original Phase 3 trial last month was still quite good. 70% overall (averaging across all doses), or 90% in the half-full dose. Oxford was the FIRST to publish formally in a journal! Moderna & Pfizer didn’t publish until later even though they were approved first.
4) Why is the Oxford #COVID19 vaccine so critical for the world?

—8-10x cheaper than Moderna/Pfizer

—Does **NOT** require any freezing! Only simple refrigeration.

—Is the #1 vaccine on order worldwide.

➡️Hence a cheap, easy to handle vaccine at 95% is huge!! Image
5) How much of the world depends on the cheap and easy to transport Oxford/AZ #COVID19 vaccine? Almost 3 bil doses—40% of the entire world 🌎’s order of 7.38 bil doses—by this one vaccine. Everyone is counting on this.

300 mil US & 400 EU is also the largest orders for them. Image
6) Some are asking why/how the new Oxford/AZ result is different — they retested the vaccine from the previous half-dose/full-dose regimen that had the earlier 90% efficacy.

To be clear, it wasn’t a safety issue before. Some critics said it was dumb luck or <55 age. Hence retest
7) My earlier thread 🧵 walks thru the denser epidemiological issues with the previous Oxford-AZ low dose trial that got the previous 90% efficacy. In short, they wanted to rerun to make sure. And the 90% result was NOT post-hoc dredging for strong funding, it was pre-registered.
8) The Oxford/AZ vaccine is not an mRNA vaccine like Moderna or Pfizer/BioNTech’s. Oxford relies on a neutralized adenovirus that is harmless, but “hitchhike” tagged with the spike genes of #SARSCoV2 coronavirus to train our cells to the spike protein. research.ox.ac.uk/amp/Article/20… Image
9) Oxford scientists say this on the adenovirus vector approach: “ChAdOx1 was chosen as the most suitable vaccine technology for a SARS-CoV-2 vaccine as it has been shown to generate a strong immune response from one dose in other vaccines...”
10) “It has been genetically changed so that it is impossible for it to grow in humans. This also makes it safer to give to children, the elderly and anyone with a pre-existing condition such as diabetes. Chimpanzee adenoviral vectors are a very well-studied vaccine type”.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Nov 13
⚠️BREAKING—ICU Hospitalized human bird flu case in Canada now officially confirmed as H5N1. Worse, it is the same 2.3.4.4b virus clade (variant group) as the one found in BC🇨🇦 poultry and in Washington state🇺🇸! The hospitalized teenager (with no pre existing conditions) had no animal contact, does not live on farm, had “deterioration quite rapid” and now critical in ICU with ARDS. Canada officials says infectious period is 2 days **prior to symptoms** (ie asymptomatic transmission) and infectious up to 10 days.Image
2) Public Health Agency of Canada's National Microbiology Laboratory (NML) in Winnipeg confirmed that the individual has avian influenza H5N1
canada.ca/en/public-heal…
3) details…

⚠️BAD UPDATE—BIRD FLU HOSPITALIZATION IN CANADIAN TEEN

Summary 🧵 of the live press conference with Canada’s British Columbia health officer.

📌The teen is in intensive care.
📌Condition is ARDS
📌Teen was healthy prior; no underlying conditions

bsky.app/profile/dreric…
Read 4 tweets
Eric Feigl-Ding Profile picture
Nov 13
Trump’s incoming SECRETARY OF DEFENSE who doesn’t wash his hands and doesn’t believe in germs. Image
2) Trump’s new SECDEF is also in favor of committing war crimes. businessinsider.com/pete-hegseth-a…
3) Trump’s SECDEF pick is a wild character. And loves hawking merch.
Read 4 tweets
Eric Feigl-Ding Profile picture
Nov 9
My god—Google Search for “what is a tariff” sudden spikes the DAY AFTER ELECTION DAY. 🤦🏻‍♂️ Image
2) many folks simply don’t understand what a tariff is — unless you explain it several times to them with analogies. Even then, it’s hard for many to grasp. Eg 👇
3) Ah shit… it’s now gotten worse. Why do so many people do their hw late??,
Read 6 tweets
Eric Feigl-Ding Profile picture
Nov 6
📍HARRIS IS STILL AHEAD IN PA—in terms of votes yet to be counted. She’s still +2 of what is needed to win PA, given the outstanding votes still remaining in PA cities, according to @CBSNews @NorahODonnell Image
Image
Image
Harris has enough remaining in PA Philly suburbs to still win. Image
3) folks. The NYT needle is not reliable.
Read 5 tweets
Eric Feigl-Ding Profile picture
Oct 31
Plastic cookware should not be used. Period. Especially BLACK PLASTIC cookware, that often mixes in toxic recycled electronic waste materials. DISPOSE OF ALL PLASTIC COOKWARE, especially if black colored plastic ones. Pass it on to your family.

Gift🎁🔗
theatlantic.com/health/archive…Image
2) Because optical sensors in recycling facilities can’t detect them, black-colored plastics are largely rejected from domestic-waste streams, resulting in a shortage of black base material for recycled plastic. So the demand for black plastic appears to be met “in no insignificant part” via recycled e-waste, according to Turner’s research. TV and computer casings, like the majority of the world’s plastic waste, tend to be recycled in informal waste economies with few regulations and end up remolded into consumer products, including ones, such as spatulas and slotted spoons, that come into contact with food.
3) You simply do not want flame retardants anywhere near your stir-fry. Flame retardants are typically not bound to the polymers to which they are added, making them a particular flight risk: They dislodge easily and make their way into the surrounding environment. And, indeed, another paper from 2018 found that flame retardants in black kitchen utensils readily migrate into hot cooking oil. The health concerns associated with those chemicals are well established: Some flame retardants are endocrine disruptors, which can interfere with the body’s hormonal system, and scientific literature suggests that they may be associated with a range of ailments, including thyroid disease, diabetes, and cancer. People with the highest blood levels of PBDEs, a class of flame retardants found in black plastic, had about a 300 percent increase in their risk of dying from cancer compared with people who had the lowest levels, according to a study released this year. In a separate study, published in a peer-reviewed journal this month, researchers from the advocacy group Toxic-Free Future and from Vrije Universiteit Amsterdam found that, out of all of the consumer products they tested, kitchen utensils had some of the highest levels of flame retardants.
Read 4 tweets
Eric Feigl-Ding Profile picture
Oct 29
⚠️MASK MANDATE RETURNING TO ALL NIH PATIENT CLINICS—Effective November 4, 2024, masking will be required in all patient care & waiting rooms. Furthermore, testing for COVID, flu A, flu B, and RSV will be required for all inpatients & rooming-in visitors.
cc.nih.gov/patient-servic…Image
Image
2) This means wearing a mask will be REQUIRED in all patient care areas, including waiting rooms. ➡️This change is due to an anticipated increase in COVID-19 and other respiratory virus activity in the community. 😷
3) I think people should stock up on COVID tests again. The Cheapest COVID test on the U.S. market is now as low as $1.50 with special promo code “COV20”… expiring Jan or March 2025.

store.pharmalynk.com/products/advin…Image
Read 6 tweets

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