And glycation reduces elasticity of soft tissues, including arterial walls. This, in turn, would lead to decreased vessel compliance and decreased visible superficial pulses, probably long before cardiac CT scans would show CAC.
https://twitter.com/ldlskeptic/status/1344740284484079616
In ortho, Advance Glycation End-Products (AGEs) is quite possibly the #1 reason why we see so many rotator cuff tears, degenerative meniscal tears, quadriceps tendon ruptures, etc in mid to older adults.
The lack of elasticity leads to a rapid increase in tensile stress in eccentric muscle contractions for a given amount of strain and leading to muscle/tendon failure (rupture).
If all this sounds foreign, just think about two rubber bands- one you just just bought at the store and the other you found in a drawer in your home sitting there happily for the last 10-15 years.
If you rapidly stretch both of them, the new one will likely not tear but the old one will. Just like rubber can go through “dry rot” over time, so can our tissues go through a similar process through glycation.
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