And glycation reduces elasticity of soft tissues, including arterial walls. This, in turn, would lead to decreased vessel compliance and decreased visible superficial pulses, probably long before cardiac CT scans would show CAC.
In ortho, Advance Glycation End-Products (AGEs) is quite possibly the #1 reason why we see so many rotator cuff tears, degenerative meniscal tears, quadriceps tendon ruptures, etc in mid to older adults.
The lack of elasticity leads to a rapid increase in tensile stress in eccentric muscle contractions for a given amount of strain and leading to muscle/tendon failure (rupture).
If all this sounds foreign, just think about two rubber bands- one you just just bought at the store and the other you found in a drawer in your home sitting there happily for the last 10-15 years.
If you rapidly stretch both of them, the new one will likely not tear but the old one will. Just like rubber can go through “dry rot” over time, so can our tissues go through a similar process through glycation.

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More from @moreyraortho

25 May 20
If you want to avoid an orthopedic surgeon at some point in your life, and don’t want lengthy, complicated advice, I have two simple principles:

1. Employ risk mitigation (this is the obvious one) : Wear seatbelts, dont text and drive, etc. (the other is not so obvious)
2. Change your diet to a #lowcarb diet for life. Why? Simple. It addresses the #rootcause or associations in most chronic diseases (obesity, high blood pressure, type 2 diabetes, coronary artery disease, many cancers, benign prostatic hyperplasia, polycystic ovarian syndrome,...
...Non-alcoholic fatty liver disease, dementia, etc) INCLUDING that which leads to joint pain/inflammation and tendon tears. Through a process called glycation, sugars get deposited on soft tissues, leading to Advanced Glycation End-products (AGEs). These AGEs...
Read 10 tweets

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