The things we are discussing about 5-HT2 antagonists and plasma serotonin, about attempting to halt progression in the early severe stage, are relevant *during* these events.
Rates of PTSD following survival from severe COVID-19 exceed 30%, ditto anxiety and depression.
The ventilator settings required to keep these patients alive tend to permit blood CO2 levels to rise somewhat, in avoiding excessive mechanical damage to the lungs.
This has been repeatedly demonstrated to cause severe anxiety and promote PTSD.
Interrupting the feedforward mechanism of elevated plasma serotonin, endothelial dysfunction, and platelet hyperactivity is about pulling patients back out of what is, essentially, hell.
Note also that serotonin syndrome of any form tends to lead to particularly agitated and anxious delirium, which further contributes even beyond the CO2 issue or the various invasive interventions.
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