@coolnidal @farid__jalali First off:
Because Zaid et al. already directly demonstrated that plasma serotonin is indeed greatly elevated in hospitalized moderate to severe COVID-19.
Therefore, this is no longer a theory, but rather an established fact about the disease process.
Because Zaid et al. already directly demonstrated that plasma serotonin is indeed greatly elevated in hospitalized moderate to severe COVID-19.
https://twitter.com/__ice9/status/1346142081148997633?s=19
Therefore, this is no longer a theory, but rather an established fact about the disease process.
@coolnidal @farid__jalali Second:
Because the excess plasma serotonin has obvious and serious ramifications for clinical symptoms and management.
It is a miserable condition to be in for even hours, much less weeks.
People thrashing, hallucinating, clawing at tubes: here's why.
Because the excess plasma serotonin has obvious and serious ramifications for clinical symptoms and management.
It is a miserable condition to be in for even hours, much less weeks.
https://twitter.com/__ice9/status/1308329855092756480?s=19
People thrashing, hallucinating, clawing at tubes: here's why.
@coolnidal @farid__jalali Journalists like videos and media, right?
Here's what it looks like.
Click this post, scroll up by one for the video.
Imagine if this were your father or uncle or grandfather.
Just weeks like that.
We can do something about this. It can be blocked.
Here's what it looks like.
Click this post, scroll up by one for the video.
https://twitter.com/farid__jalali/status/1308312744504950784?s=19
Imagine if this were your father or uncle or grandfather.
Just weeks like that.
We can do something about this. It can be blocked.
@coolnidal @farid__jalali Third:
Because highly elevated plasma serotonin levels are known to cause the same major immunological effects observed in severe COVID-19.
It may or may not be responsible for the entire effect, but it gets the direction right for all of them. Thread:
Because highly elevated plasma serotonin levels are known to cause the same major immunological effects observed in severe COVID-19.
It may or may not be responsible for the entire effect, but it gets the direction right for all of them. Thread:
https://twitter.com/__ice9/status/1345738674793803777?s=19
@coolnidal @farid__jalali Fourth:
Because treating this issue is simple, inexpensive, accessible, and very low risk.
Cyproheptadine is a 5-HT2 antagonist, already standard treatment for serotonin syndrome.
Already saving COVID-19 patients.
Summary here, click for full thread:
Because treating this issue is simple, inexpensive, accessible, and very low risk.
Cyproheptadine is a 5-HT2 antagonist, already standard treatment for serotonin syndrome.
Already saving COVID-19 patients.
Summary here, click for full thread:
https://twitter.com/__ice9/status/1345500377228201986?s=19
@coolnidal @farid__jalali Fifth:
Because medical literature dating back decades already establishes high levels of plasma serotonin promote:
- pulmonary embolism
- pulmonary vasoconstriction
- pulmonary hypertension
- right-sided heart failure
- fibrosis
All in severe COVID-19.
Because medical literature dating back decades already establishes high levels of plasma serotonin promote:
- pulmonary embolism
- pulmonary vasoconstriction
- pulmonary hypertension
- right-sided heart failure
- fibrosis
All in severe COVID-19.
https://twitter.com/__ice9/status/1345473434965471233?s=19
@coolnidal @farid__jalali Sixth:
Because hyperactive platelets explain 'heparin resistance' in severe COVID-19, when the blood of a patient on anticoagulants still clots in vessels, often in spite of bleeding elsewhere.
AC also increase bleed risk more than antiplatelet drugs.
Because hyperactive platelets explain 'heparin resistance' in severe COVID-19, when the blood of a patient on anticoagulants still clots in vessels, often in spite of bleeding elsewhere.
https://twitter.com/__ice9/status/1330614811999268869?s=19
AC also increase bleed risk more than antiplatelet drugs.
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