bAlabodhana: a version of this molecule (more precisely with an additional -OH bonded to the C2' atom has been a key technological advance in the mRNA vaccines being rolled out. The relevant part is that hexagonal ring (the base) called 1N-methylpseudouracil
The mRNA vaccines are the triumph a still hazy principle in biology termed "social RNA". The reason for is that many organisms have an inbuilt immune action directed against social RNA for it could be a pathogenic RNA. The key idea in these vaccines is the use of the above base
systematically instead of its usual base uracil. This N-methyl pseudouridine does 2 things: makes the vaccine RNA less capable of triggering the body's anti-RNA immunity &inflammatory response & simultaneous makes it a better mRNA i.e. better for protein production. If as
expected the vaccines work then this will be the first step in the development of future vaccines with greater efficiency and most importantly short turnover times. However, this does not address the specific safety issues at this point: will the largescale introduction of
N methylpseudouridine result in development of immune responses against endogenous pseudouridines. Will there be eventual interference with slow developing anti psU immune responses when used as part of multi-vaccine regimens. Unfortunately, we do not know enough. Will do a
parallel thread on the alternative approaches to a vaccine.

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5 Jan
The vA~Nga cult of manasA has many unusual features not seen in the south. It is also rather unusual that she rose to be one of the most celebrated goddesses of the region. Some of those include: 1) He identification with an ancient goddess padmAvatI (shown with a snake in jin
tradition. 2) Her rivalry with the goddess chaNDikA who blinds one of her eyes. 3) Her unusual companion netA the laundrywoman of the deva-s. 4) Her rise to prominence involving the forcible conversion of a v3 of gAndhin (perfumer seller; like MKG) caste. 5) Her role in reviving
rudra after he drink viSha during the churning of the ocean. 6) Having a head like Channa fish.7) A late element of the vernacular ma~Ngala-kAvya-s of the vA~Nga-s: the subjugation of predatory Mohd sardar-s by manasA who sends a great horde of venomous animals to slaughter their
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5 Jan
While there is a lot of modern literature on cattle behavior much of it is directed at herds where some disruption might have occurred: e.g. hormonal implants; male removal; regular removal of members shaking up dominance hierarchies; unavailability of seclusion during calving;
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A few e.g. apratiratha aindra: AshuH shishAno vR^iShabho na bhImaH | -> the bull sharpening its horns: derived from behavior of bull of horning the ground: a threat display
sadyo jAto vR^iShabho roravIti -> roaring of bull a dominance display;
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5 Jan
This article stirred up some feelings from the past: Was fascinated by the artistry in these pens& was also enamored by my late grandparents' facility writing with these pens but really found it hard to write with them as a kid.Hence, I junked them despite…
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3 Jan
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3 Jan
1 observes that in India or many nations of the occident there is a fear of certain facts, i.e. quite reliable inferences based on reproducible observations, being "weaponized". The general reaction is to deny those facts by claiming them to be false or the exact opposite. This
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The Soviet Union did the same by force and several occidental nations are doing the same now: such denial can only be maintained by such. In contrast while the late Singaporean leader was called many names he decided to play along with with uncomfortable facts. The H really need
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1 Jan
There is a certain mental tendency that exists across groups to accept a patently contra-factual framework as reality. Once that is accepted the individuals who have done so work within that framework & to them the factual reality or pratyakSha appears delusional. To such people
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