learning from our mistakes, and taking lessons from those who have handled this pandemic best

a Trainspotting inspired🧵1/n

at the start of this pandemic, the WHO and others advised that restricting international travel was not an effective way to stop the spread of SARS-CoV-2
who.int/news-room/arti… 2/n
we now know that this was wrong 3/n
the deadliest infectious disease event of the last century, the 1918-19 Spanish Influenza pandemic, was propagated by the main form of mass transportation at the time: sea travel during the closing stages of World War I 4/n
this century’s deadliest pandemic (*so far*) has in turn been spread by international air travel

numerous research studies in the countries hardest hit by Covid-19 (United Kingdom, United States, Brazil) have arrived at the same findings regarding importation 5/n
the virus arrives in hundreds or thousands of separate events, and from these is seeded to spread throughout the entire population

science.sciencemag.org/content/early/… @ScienceMagazine @laduplessis @arambaut @erikmvolz 6/n Image
for Scotland, research has found that the virus had been introduced at least 283 separate times, mainly from continental Europe, and most commonly from Italy
nature.com/articles/s4156… 7/n
I believe that we could have avoided this first wave in Scotland

the novel coronavirus was first reported to the WHO on the 3rd of January 2020

who.int/emergencies/di… 8/n
by the 14th of January we knew that there was human to human transmission
9/n
by the 9th of February there were reports of it being spread by attendees at international conferences, in this case a business meeting in Singapore
bloomberg.com/news/articles/…

despite this large conferences were still being held in Scotland at the end of February 10/n
by the 21st of February we knew that SARS-CoV-2 was spreading within Italy.
reuters.com/article/us-chi… 11/n
but in Scotland we were too slow to act: advice was issued to self-isolate after returning from travel to selected parts of Northern Italy only, and not from Italy as a whole, 4 days later
gov.scot/news/coronavir… 12/n
only on the 10th of March did the Scottish government advise all international travellers to self-isolate on return from travel abroad

and only in early June did the UK government start to enforce these quarantine rules 13/n
the first lockdown, although painful in a number of ways, and extended for longer in Scotland than in England, was highly effective

by some days in July we were down to just 2 confirmed Covid-19 cases in the *entire country* @TravellingTabby @P_H_S_Official 14/n
further research, conducted by my academic and NHS colleagues, suggests that there were only a handful of viral lineages left at this point in Scotland, each causing a small number of cases 15/n

cogconsortium.uk/wp-content/upl… Image
but by September we were back to rising case counts. The source of these new cases?

travel again, this time from England and continental Europe 16/n
screening travellers is not enough

we know that airport screening is resource intensive, and often ineffective due to the incubation time of the virus
cochrane.org/news/cochrane-…

RT-PCR without enforced quarantine is ineffective too 17/n Image
the countries that have handled this pandemic best are those that have been able to secure and control the passage of people across their borders 18/n
Taiwan, Australia and New Zealand, to pick from the small number of countries that have managed to keep case counts relatively low, introduced stringent travel restrictions from the start of the pandemic 19/n
most importantly, they adopted measures to ensure that new arrivals complied with quarantine regulations 20/n
their low infection rates and tight handle on cases allows them to act quickly and decisively to investigate and contain outbreaks

in August, when a cluster of 4 cases was detected in Auckland (pop. 1.6 million)went into lockdown for 19 days news.sky.com/story/coronavi… 21/n
this strategy has proven highly successful: the last case of community transmission in New Zealand was on the 18th of November
health.govt.nz/our-work/disea… 22/n
in contrast in a Scotland with (at last count) 2309 cases a day, this degree of disease surveillance and control remains a distant dream

more vaccines will be arriving soon, but so far only just over 100,000 adults have been vaccinated

leaving 4.3 million unprotected 23/n
by May we may well have vaccinated those over fifty and the most vulnerable thenational.scot/news/18985311.…

but we are unlikely to have full (adult) population coverage until late summer, the autumn or even beyond 24/n
even these optimistic schedules are contingent on vaccine availability: manufacturers are already struggling to keep up with demand metro.co.uk/2021/01/01/cov…

in addition, we have no clinical trials to guide vaccinating the 1 million children and young people in Scotland 25/n Image
given that we can’t rely on vaccines to get us out of our current dire situation

let’s learn from our previous mistakes, and take lessons from those who have handled the pandemic best

Let's: 26/n
Choose to continue to restrict travel, including from England, unless it is absolutely essential
gov.scot/publications/c… 27/n
Choose to strictly enforce breaches of travel quarantine 28/n
Choose to think hard about continuing these travel restrictions beyond lockdown, until national case numbers are so low that we can effectively investigate and contain local outbreaks 29/n
Choose to seamlessly transition from a Scotland with very low case numbers, to one where everyone is vaccinated 30/n
Choose to minimise unnecessary death and disruption to healthcare and education 31/n
Choose to make sure that this lockdown is the last one we have to endure 32/n

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More from @Williams_T_C

3 Jan
could a non-segmented RNA virus rapidly evolve to evade a polyclonal immune response, rendering a vaccine ineffective?

I think if you'd asked the average RNA virus researcher a year ago, the answer would have been no

but then again, 2020 wasn't an average year ... 🧵1/n
what has been shown is that if you grow a virus in culture in the presence of a *monoclonal* antibody (mAb)

you will select for mutations that render the virus resistant to that mAb

this has been shown in the lab for measles, polio, and RSV sciencedirect.com/science/articl… 2/n
Read 19 tweets
3 Dec 20
with Scotland due to start vaccination next week with the Pfizer/BioNTech BNT162b2 coronavirus vaccine, what do we know about it?

a thread

bbc.co.uk/news/uk-scotla…
first of all, what type of vaccine is it?

BNT162b2 is an mRNA vaccine. Although the SARS-CoV-2 vaccines are the first of this family to be licensed, they have been studied for many years in influenza, Zika, rabies and RSV @CDCgov

cdc.gov/vaccines/covid…
the mRNA in the vaccine contains nucleoside modifications to make it more stable, and is packaged in lipid nanoparticles so that the the mRNA is taken up by cells.

as mRNA is the minimal genetic vector, anti-vector immunity is avoided.
nature.com/articles/nrd.2…
Read 19 tweets

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