Phil Kerpen Profile picture
17 Jan, 6 tweets, 2 min read
NATURE: "We tested 690 respiratory samples from the 129 patients for the presence of infectious virus using cell culture and determined the viral RNA load with RT-qPCR (Fig. 1). Infectious SARS-CoV-2 was isolated from 62 respiratory tract samples (9.0%) of 23 patients (17.8%)."
"The median time of infectious virus shedding was 8 days post onset of symptoms (IQR 5–11, range 0–20) and probit analysis showed a probability of ≤5% for isolating infectious SARS-CoV-2 when the duration of symptoms was 15.2 days (95% CI 13.4–17.2) or more."
"The median viral load was significantly higher in culture positive samples than in culture negative samples (8.14 versus 5.88 Log10 RNA copies/mL, p < 0.0001) and the probability of isolating infectious SARS-CoV-2 was less than 5% when the viral load was below 6.63."
"A serum neutralizing antibody titre of at least 1:20 (OR of 0.01 (CI 0.003-0.08; p < 0.001) is independently associated with non-infectious SARS-CoV-2."
"We conclude that quantitative viral RNA load assays and serological assays could be used in test-based strategies to discontinue or de-escalate infection prevention and control precautions."

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More from @kerpen

17 Jan
This is so important. If you're over 65 (or under but medically high risk) and test positive GET THE ANTIBODY DRIP. If your doctor doesn't know anywhere to get it, call hospitals/infusion centers around town until you find it. This is ridiculous.
This is who qualifies for the antibody infusion:
For my local friends, we have a large antibody infusion center now at Washington Hospital Center! Spread the word.
Read 5 tweets
15 Jan
United States Influenza testing, week 1.

CDC flu view. cdc.gov/flu/weekly/ind…

Five-year average: 6,814 cases, 16.90% positive
This year: 107, 0.27%

docs.google.com/spreadsheets/d…
United States Influenza testing, season to date (15 weeks, 40 to 1)

Five-year average: 40,264 cases, 9.90% positive
This year: 1275, 0.19%
Influenza-Like Illness (ILI) continues to track lower than the mild 2015-16 season.
Read 6 tweets
4 Jan
United States Influenza testing, week 52.

CDC flu view. cdc.gov/flu/weekly/ind…

Five-year average: 17.44% positive
This year: 0.21%

docs.google.com/spreadsheets/d… Image
United States Influenza testing season-to-date (13 weeks from 40 to 52).

CDC flu view. cdc.gov/flu/weekly/ind…

Five-year average: 8.49% positive
This year: 0.18% Image
Influenza-Like Illness (ILI) continues to track well lower than the very mild 2015-16 season. Image
Read 6 tweets
4 Jan
DC reports 3 deaths with COVID. Now 9 total in January.

Positives / Tests %
1-Day: 140 / 3,119 4.49%
7-Day: 1562 / 35,244 4.43%
14-Day: 3164 / 86,981 3.64%
28-Day: 6585 / 182,035 3.62%
Positives and tests by week.

Note the dropout in negative tests was a holiday phenomenon observed nationally.
Total COVID-19 Patients in DC Hospitals: 251
Total COVID-19 Patients in ICU: 71
Total Patients in DC Hospitals (COVID and non-COVID): 1,921
Read 5 tweets
3 Jan
DC reports 2 deaths with COVID. Now 6 total in January.

Positives / Tests %
1-Day: 255 / 6,622 3.85%
7-Day: 1562 / 35,153 4.44%
14-Day: 3163 / 88,701 3.57%
28-Day: 6628 / 183,367 3.61%
Total COVID-19 Patients in DC Hospitals: 245
Total COVID-19 Patients in ICU: 69
Total Patients in DC Hospitals (COVID and non-COVID): 1,924
7-day Positives (raw and test-adjusted) and Deaths
Read 4 tweets
2 Jan
DC reports 4 deaths with COVID.

Positives / Tests %
1-Day: 257 / 7,076 3.63%
7-Day: 1553 / 37,751 4.11%
14-Day: 3167 / 90,379 3.50%
28-Day: 6637 / 183,991 3.61%
Total COVID-19 Patients in DC Hospitals: 237
Total COVID-19 Patients in ICU: 70
Total Patients in DC Hospitals (COVID and non-COVID): 1,929
7-day positives (raw and test-adjusted) and deaths
Read 4 tweets

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