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Mark Toshner Profile picture
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24 Jan, 5 tweets, 1 min read
Vaccine news coming out of Israel remains positive. google.co.uk/amp/s/amp.ft.c…

Few comments. 1/n
The statements on antibodies are reassuring and in line with the infection profile 2/n
However most of this data pertains to younger HCWs. I still think for HCWs the UK calculated gamble to delay second jab is reasonable and one I am personally comfortable with having had only one. I haven’t seen any older population data... 3/n
... and this is probably simply because it is easier to collate data, samples and follow-up people in hospital systems. 4/n
On balance I am still supportive of the current approach but acknowledge it remains a calculated gamble. Important thing to remember is Pfizer jabs will be the minority in UK so this story needs better context.

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More from @mark_toshner

Mark Toshner Profile picture
24 Jan
Thought a longer thread on the Pfizer delayed dose in UK might be useful. 1/n
Firstly important to keep local UK context clear. Pfizer will end up a minority vaccine in UK so this will not have much of a long-term effect on population coverage. However because of the way we are prioritising, it will disproportionately land in 2 groups. 2/n Image
Those are HCWs and over 80s. HCWs are as a population low risk for serious complications. They are at the front of the queue for the same reason you put your O2 mask on yourself first before your child on an airplane. Right now we are generally pretty critical. 3/n
Read 13 tweets
Mark Toshner Profile picture
23 Jan
Timing seems odd, but we need to start the conversation about the second UK NHS restart. Why do this when we are still up to our necks in the current wave? 1/n
Firstly, at some point this will either improve for the NHS or become a cyclical new normal for most of the year. In either scenario we still need to figure out the reopening of services 2/n
This was hard enough first time. Many staff were shell-shocked with no time to recover before being asked to go flat out again to clear backlogs. This meant going into wave 2 with no rest. Wave 2 has become wave 3 and the signs of staff burnout are hard to ignore 3/n
Read 10 tweets
Mark Toshner Profile picture
30 Dec 20
I've been tweeting about vaccines for a while now. Next 6 months are crucial in misinformation war so here are a few things I have learned 1/n
1) Vaccine hesitancy is widespread, and a lot of it is soft. Many folk just need simple concerns addressed 2/n
2) People have a complex set of concerns. You need to understand them. Some can be addressed, some not. Keep an eye on what they are as they change 3/n
Read 10 tweets
Mark Toshner Profile picture
20 Nov 20
Next vaccine thingy to address. Getting asked mostly about long term vaccine effects. Important to be straight/honest. Nobody knows yet. Best way to understand the future is to look at past so... 1/n
... if you look at every vaccine ever developed, you see a clear pattern. Side effects are overwhelmingly short term. It is built into how vaccines work. 1-2 doses promote short term immune response that primes us for later. 2/n
You probably don't even think twice about this when you get your flu jab. Let's be honest, who has read the evidence for flu jabs (I haven't). It is such a non-event I roll up and get one, feel a bit rough for 2 days, moan to my wife then get on with life. 3/n
Read 8 tweets
Mark Toshner Profile picture
17 Nov 20
More on vaccines. I'm going to get boring and geeky on this (no apologies) on the 10 year thing. Vaccines "normally take 10 years". This is being use as a reason to be fearful (ie rushed job). I'm a clinical trials doc. I can tell you most of that time is spent doing...1/n
.... nothing. It's spent submitting funding requests, then resubmitting them, then waiting, then submitting them somewhere else, then getting the money but the company changes it's mind or focus, then renegotiating then submitting ethics, then waiting for regulators...2/n
...then having problems with recruitment and having to open other sites, then dealing with more regulatory issues, then finally when you eventually get to the end of all of this you might have a therapy...3/n
Read 7 tweets
Mark Toshner Profile picture
13 Nov 20
On vaccine safety. 13 million vaccinated people studied. Mortality rates much lower than background population. Not a comment on causation (though seems bloody obvious), only safety
sciencedirect.com/science/articl…
With this in mind I present 5 things a vaccine is safer than 1/n
Based on above and NO REPORTED DEATHS in the 1000s of patients so far enrolled in vaccine studies, here are 5 things more dangerous than a COVID vaccine
Number 1 (close to my heart after Scotland heroics)

Watch football penalties
ncbi.nlm.nih.gov/pmc/articles/P…
Number 2 (HSE 2020)
Climbing up something at work Image
Read 7 tweets

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