Thread on something really important.
At the outset of the pandemic, @DrMikeRyan called on us to "break the chains of transmission".
We haven't. The chains now number over 100,000,000 people.
Why? A central measure is often overlooked: isolating those exposed to the virus.
The above graph by @Paul5cott compares policy measures around the world on isolation and quarantine.
A lot of focus has been on reducing the random seeding of new chains of transmission through travel.
That's important - but only one part of containing Covid-19 spread.
It sounds simple: if everyone who currently has the virus right now could be kept separate from other people for about two weeks, infections would drop to zero. Pandemic over.
But individuals cannot achieve it alone. Isolation only works within a system of support and enforcement
Survey data shows that a very low percentage of people who are just 'told' to self-isolate actually do it.
A study of 32,000 people in the UK over three months last year found only 18% of them actually kept away from others. In the Netherlands, data indicates it's about 44%.
A large proportion of those who ventured out despite being warned they had been exposed to Covid-19 did so to go to work.
Others have to buy groceries, or medicines, or need something for their child.
It's not just people being dicks -- they need support.
In order to stop chains of transmission, countries around the world have brought in a range of supports and enforcement for self-quarantine -- illustrated by @Paul5cott with data collected by @Patel_Jay_ of @GlobalHealthGP
Meal deliveries, daily check-ups, sick pay, enforcement.
Isolation, including of travellers, can be done at home. But only if the person is kept totally apart from other household members.
If not, then they need to be provided with somewhere like a hotel room to be alone, as in New York, Norway, Denmark, Singapore, Japan, many others.
(Ireland is strange here. The HSE sanctions mixing with other household members for people who have been exposed to Covid-19 -- a leaky isolation policy).
Here's what happens in Australia:
Anyone exposed to Covid-19 is handed a legally-binding quarantine order with instructions on what they can and can't do.
It lays out steep fines for breaking quarantine. The order alone is enough for vast majority to comply, says @NICU_doc_salone
People quarantining are then smothered with support.
"We call them usually every day, we can arrange groceries. If they need to see a GP for something different we can help them with that, if they are alcoholics we can find them support," @NICU_doc_salone told me.
Some places like South Korea use geo-tracking apps. In New York, teams of neighbourhood helpers knock door-to-door, arranging anything that the person in quarantine needs. In Taiwan, they'll organise garbage collection for you.
East Asian countries had the advantage in rolling out these systems of past epidemic experience and strong decentralised public health systems.
But examples in the US show how much can be done if we choose to adjust, like New York's hotel quarantines and neighbourhood health hubs
Here's an incredible figure: in the US, 27% of employees do not have paid sick leave.
This study found that the introduction of two weeks' emergency sick pay due to the pandemic saw a drop of 400 Covid-19 cases -- per day, per state! healthaffairs.org/doi/pdf/10.137…
Advantage of keeping cases low is that you can surround those people exposed to the virus with every possible support. As cases grow exponentially, becomes exponentially harder to do.
Then, in lieu of targeted confinement, we end up with confinement of all irishtimes.com/news/health/co…

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More from @NaomiOhReally

29 Jan
Taoiseach Micheál Martin has held discussions with Ursula von der Leyen amid deep unhappiness in the Irish government at the use of Article 16 -- seen as "completely unnecessary" with "explosive political implications" according to a government source
irishtimes.com/news/health/eu…
UK government spokesman says Michael Gove has been in touch with EU Commission's Maros Sefcovic and that the British government is now "carefully considering next steps".
Hours since its publication, the European Commission's vaccine export control regulation has been unpublished from its website
Read 8 tweets
28 Jan
My understanding of AstraZeneca's EU doses:
- contract signed in August
- EU expected over 100 mln doses delivered by end-March, possibly 120 mln
- in early Dec, AZ revised down to 80 mln
- on Jan 22, AZ revised to 31 mln
- distributed proportionally: eg Ireland's share is ~1.1%
Meanwhile, on Jan 13, AstraZeneca chief Tom Keith-Roach told a UK parliament hearing it was scaling up vaccine deliveries "very rapidly" and by mid-Feb would be able to deliver two million doses to the UK every week.
Up to that point, 1.1 mln doses had been delivered to UK.
AZ and UK govt have represented UK doses as made in UK, and visa versa for EU.
However, on December 8, the UK's Vaccine Taskforce manufacturing lead Ian McCubbin told reporters that
"The initial supply... actually comes from the Netherlands and Germany."
reuters.com/article/uk-hea…
Read 14 tweets
27 Jan
The EU has asked AstraZeneca to make the contract public as it disagrees with the interpretation put forward by CEO Pascal Soriot, according to an official, who suggests this could be a breach of the contract confidentiality the company had insisted on.
The EU believes there are stocks of vaccines produced in Europe, that it wants to be delivered to the EU to fulfil its contract.
The factory that has an issue is not the most vital to supply, according to official.
"We are trying to get the vaccines that are somewhere in Europe."
The idea that there are separate supply chains for the UK is not reflected in the contract, according to official.
Two factories located in the UK are the primary ones slated for EU supply, followed by one in Belgium (which has a problem) and one in Germany, official says.
Read 5 tweets
26 Jan
EMA head Emer Cooke responds to questions about AstraZeneca's trial data, and the fact that there were a relatively small % of older people in the trial:
"The studies that were done that have been included in the file so far have a very small quantity of elderly populations..."
"This is what is being discussed in the media atm
Our scientific committee is looking at the totality of the data to see what that data means in terms of the populations that were studied and what could reasonably be expected in populations that maybe have not been studied yet."
"This is a normal process in relation to any vaccines. We have to look at the data that’s there, look at the science behind it, and what we can expect that data to mean."
Read 7 tweets
24 Jan
A very interesting area. I have heard from both @WHO and @NICU_doc_salone that what's vital isn't punitive enforcement but SUPPORT for quarantine.
The NZ and Aus legislation on mandatory self-isolation and quarantine are here...
legislation.govt.nz/regulation/pub…
health.nsw.gov.au/Infectious/cov…
If you only have a few infections, you can really put resources into making sure they don't spread further.
In Australia, if you have to self-isolate you are handed an official order that explains exactly what you can and can't do... health.nsw.gov.au/Infectious/fac…
Getting an official order on paper in itself is enough to get compliance from the vast majority of people, @NICU_doc_salone told me.
The order also notes that if you break the rules, the maximum penalty is a $11,000+ fine and six months in prison... health.nsw.gov.au/Infectious/fac…"
Read 7 tweets
9 Jan
How is international media reporting Ireland's dramatic Covid-19 surge that has taken it from one of the lightest-affected in Europe to a global hotspot in a matter of weeks?
Always interesting to see an international perspective.
A press review:
"Ireland is the country in the world where the epidemic is spreading the fastest, ahead of the Czechia and the United Kingdom," reports Belgium's @RTBFinfo rtbf.be/info/societe/d…
"It must be said that the Irish situation is in fact much more serious: if in the United Kingdom, infections have increased by 50% in one week, in Ireland, they have quadrupled!" @RTBFinfo adds
Read 24 tweets

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