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Mark Toshner Profile picture
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30 Jan, 4 tweets, 1 min read
@BijuCherianDr really important point in thread (and thanks for nod). We saw early in ChadOx that BAME underrepresented. This is panning out also in vaccine rollout. We need to urgently address complex, difficult community concerns. 1/n
Valid and deeply held concerns about govt, institutions and medical scientists that have not always had their back. These are added to the normal mix of mostly addressable safety concerns. I’m white and pretty privileged. Hard for me to walk a mile in their shoes. 2/n
We need community voices, strong leadership from trusted sources to stand up and join us. By definition this will not be won by public health/govt or even NHS and independent scientist voices because 3/n
we haven’t earned trust historically. We need a different approach to reach the communities who are sadly most likely to be affected by this blight. If you can help, then now is the time. If I can help you in this, let me know

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More from @mark_toshner

Mark Toshner Profile picture
30 Jan
Quick tweetorial on why the design of the different vaccine studies is important. I'm also going to talk about how reporting has coloured the debate.

My disclosures- Minor investigator on ChAdOx trial. No funding to declare. 1/n
First thing is funding/ sponsorship (who is responsible for trial). Most western vaccines are commercially sponsored and funded though with variable govt involvement. Exception was ChAdOx which was sponsored by Oxford Uni (with some trials yet to report further from AZ) 2/n
Why is this important? Because you may want to know how independent the studies are. E.g. Some concern about Russian Sputnik because it clearly isn't. Some people don't trust drugs companies so those ones may come under different scrutiny. 3/n
Read 18 tweets
Mark Toshner Profile picture
24 Jan
Thought a longer thread on the Pfizer delayed dose in UK might be useful. 1/n
Firstly important to keep local UK context clear. Pfizer will end up a minority vaccine in UK so this will not have much of a long-term effect on population coverage. However because of the way we are prioritising, it will disproportionately land in 2 groups. 2/n
Those are HCWs and over 80s. HCWs are as a population low risk for serious complications. They are at the front of the queue for the same reason you put your O2 mask on yourself first before your child on an airplane. Right now we are generally pretty critical. 3/n
Read 13 tweets
Mark Toshner Profile picture
24 Jan
Vaccine news coming out of Israel remains positive. google.co.uk/amp/s/amp.ft.c…

Few comments. 1/n
The statements on antibodies are reassuring and in line with the infection profile 2/n
However most of this data pertains to younger HCWs. I still think for HCWs the UK calculated gamble to delay second jab is reasonable and one I am personally comfortable with having had only one. I haven’t seen any older population data... 3/n
Read 5 tweets
Mark Toshner Profile picture
23 Jan
Timing seems odd, but we need to start the conversation about the second UK NHS restart. Why do this when we are still up to our necks in the current wave? 1/n
Firstly, at some point this will either improve for the NHS or become a cyclical new normal for most of the year. In either scenario we still need to figure out the reopening of services 2/n
This was hard enough first time. Many staff were shell-shocked with no time to recover before being asked to go flat out again to clear backlogs. This meant going into wave 2 with no rest. Wave 2 has become wave 3 and the signs of staff burnout are hard to ignore 3/n
Read 10 tweets
Mark Toshner Profile picture
30 Dec 20
I've been tweeting about vaccines for a while now. Next 6 months are crucial in misinformation war so here are a few things I have learned 1/n
1) Vaccine hesitancy is widespread, and a lot of it is soft. Many folk just need simple concerns addressed 2/n
2) People have a complex set of concerns. You need to understand them. Some can be addressed, some not. Keep an eye on what they are as they change 3/n
Read 10 tweets
Mark Toshner Profile picture
20 Nov 20
Next vaccine thingy to address. Getting asked mostly about long term vaccine effects. Important to be straight/honest. Nobody knows yet. Best way to understand the future is to look at past so... 1/n
... if you look at every vaccine ever developed, you see a clear pattern. Side effects are overwhelmingly short term. It is built into how vaccines work. 1-2 doses promote short term immune response that primes us for later. 2/n
You probably don't even think twice about this when you get your flu jab. Let's be honest, who has read the evidence for flu jabs (I haven't). It is such a non-event I roll up and get one, feel a bit rough for 2 days, moan to my wife then get on with life. 3/n
Read 8 tweets

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