John Bye Profile picture
31 Jan, 29 tweets, 13 min read
Sceptics make wild claims about the number of deaths caused by lockdown, but there's no evidence to support them.

The vast majority of excess deaths last year were directly caused by ("from", not "with") covid-19.

So what do ONS and PHE data and academic studies actually show?
Removing covid deaths, you can see more clearly that despite 10 months of varying levels of restrictions, the only time there have been large numbers of non-covid excess deaths was during the first wave.

Mostly elderly care home residents registered as dying from dementia.
We now know that many elderly people suffering from covid experience confusion and delirium, often without a cough or fever.

This is obviously easily mistaken for other, pre-existing conditions.

The same thing is thought to happen with flu each winter.

bbc.co.uk/news/health-54…
So while some excess dementia deaths may be due to issues in care homes and lack of hospital care, given the almost total lack of testing in care homes in April, many are likely to be undiagnosed covid.

This was raised by the ONS as early as June.

ons.gov.uk/peoplepopulati…
And a more recent study by Manchester University suggests that MOST "non-covid" excess deaths in care homes during the first wave may actually have been undiagnosed covid.

Which would add as many as 10,000 more deaths to the official covid death toll.

manchester.ac.uk/discover/news/…
Another sign is that there haven't been ANY excess deaths due to dementia and Alzheimer's since the first wave.

This is despite varying restrictions on visiting care homes over the last few months, which you would expect to have had a negative impact on vulnerable residents.
Finally, a recently released report to Sage estimated that there could be 22,000 more non-covid excess deaths in care homes over winter, based on the first wave's 10,000 "non-covid" deaths.

Thankfully they seem to be wrong.

So whatever happened in April, it isn't happening now.
The other main cause of non-covid excess deaths is disruption to hospital care.

This includes the (in hindsight over zealous) bed clearing operation in the first wave, delays to treatment, staff and bed shortages due to covid, and people not going to A&E for genuine emergencies.
For example, the Sage report estimates 4,000 excess deaths were caused in the first wave by people being unwilling or unable to access emergency care.

But they also estimated a further 10,000 deaths over the winter.

Again, there's thankfully no sign yet of this happening.
Possibly related to this, circulatory diseases are the only cause seeing any significant numbers of excess deaths throughout the year.

There were 5,707 excess deaths due to these causes (2,090 involving covid).

About half were in April, the rest spread over the next 8 months.
There's a spike in urinary disease excess deaths in April (439, of which 52 involved covid) but only 114 since then (which is less than the 193 that involved covid).

Liver diseases have seen small numbers of excess deaths all year, but only 735 in total (254 of them with covid).
The wide ranging "other causes" also shows a spike in the first wave, but then nothing.

The much smaller spike at the end of the year is (at least partly) due to bank holidays (which cause reporting delays) being spread across the weeks differently in 2020 than in most years.
And again, the ONS think that at least some of the "other causes" deaths in the first wave, reported as "symptoms, signs and ill-defined conditions" (which includes general frailty and old age), may have been undiagnosed covid.
The other issue related to hospitals is access to routine screening and surgery.

The report to Sage estimates there may be 8,600 excess deaths due to disruption to elective surgery, and 1,400 due to delays to cancer treatment and diagnosis, but spread over several years.
They estimate many more deaths due to disruption over the winter (bringing the total to 18,200). But again, this seems to be based on mistakes made in April.

And as we've just seen, the main thing causing disruption to the NHS this winter was the large numbers of covid patients.
Obviously there won't be much sign of these longer term impacts yet, but there were 1,388 excess deaths reported due to cancer in April (at least 374 of them involving covid).

There haven't been any more since then though.
So most "non-covid" excess deaths are NOT due to the lockdown itself, as sceptics imply, but due to issues in the NHS during the first wave, and undiagnosed covid.

And there's no sign of excess non-covid deaths in later national or regional lockdowns, when the NHS was more open.
Meanwhile non-covid respiratory diseases were below average all year (even before covid), apart from a bump in April that's probably undiagnosed covid.

The big drop this winter is at least partly due to other diseases being affected by measures taken to slow the spread of covid.
In fact the report to Sage estimates the impact of restrictions so far is 4,000 LESS non-covid deaths, thanks to everything from fewer accidents and better air quality to a reduction in other infectious diseases.

So even ignoring covid, lockdowns saved more lives than they cost.
Lockdown sceptics also point to increased deaths at home as a sign that lockdown has been killing people.

But these remained high over the summer, despite most restrictions being lifted then, and haven't increased much as new restrictions were introduced in the last few months.
It's noticeable that the number of excess deaths in homes almost exactly mirrors below average non-covid deaths in hospitals.

It's hard to say without more detailed data, but it looks possible that some people who would normally have died in hospital sadly died at home instead.
Looking at other settings, most excess deaths in hospitals and care homes throughout the pandemic have involved covid.

It's also worth noting that deaths in hospices were below normal. Again, maybe some people sadly died at home rather than receiving hospice care?
Another common claim is that lockdown is killing the young, whereas covid mostly kills the elderly.

Again, there's no evidence of this.

There are no excess deaths overall in people under 45, and most of the excess deaths in the 45-64 age group involved covid.
Covid (like most things) disproportionately kills the elderly, and sadly that's reflected in the excess death figures.

The vast majority of excess deaths last year are in people over 65, and most of those involved covid.
So:
- Most excess deaths are due to covid
- There are no excess deaths in the young
- Only circulatory diseases show significant excess deaths
- Many non-covid excess deaths in April seem to be undiagnosed covid
- Excess deaths at home may be displaced from hospitals and hospices
The other aspect the report to Sage looks at, which is impossible to judge yet, is long term deaths caused by reduced life expectancy as a result of the recession.

Their latest estimate is that this might cause 40,000 excess deaths. But that's spread over a 50 year period.
Most countries have had a recession due to the pandemic, regardless of what measures they took.

Ours is worse than most because our economy is more reliant on the service sector, and we locked down too late and did too little to avoid further lockdowns.

edition.cnn.com/2020/08/12/eco…
Lots of other countries locked down earlier and harder than us and managed to get the disease under control faster, and as a result had much milder recessions AND less deaths.

We ended up with the worst of both worlds by trying to walk a tightrope between health and the economy.
Sources:

Sage direct & indirect impacts of covid-19 report:
assets.publishing.service.gov.uk/government/upl…

PHE excess mortality data:
fingertips.phe.org.uk/static-reports…

ONS deaths data:
ons.gov.uk/peoplepopulati…

ONS weekly deaths reports:
ons.gov.uk/peoplepopulati…

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More from @_johnbye

1 Jan
The latest Test & Trace report is out, covering the week before Christmas.

Cases in London and the South East were soaring, and an outbreak of coronavirus at the Lighthouse Lab in Milton Keynes caused further issues in the testing system as demand for tests rapidly increased.
There was another big increase in testing as demand rose, with increasing numbers of quick but less sensitive Lateral Flow Tests being used to screen asymptomatic people.

In total 2.6 million tests were done. But a higher percentage than last week were positive.
If you separate Lateral Flow (which are ONLY used on asymptomatic people) and PCR (which are used on both symptomatic and asymptomatic people) tests, positivity for PCR is back to the peak last seen at the beginning of November, while positivity for LFTs is rising fast now too.
Read 15 tweets
28 Dec 20
It's sad we still need to say this, but false positives are NOT driving rising cases.

In the summer the False Positive Rate (FPR) at lots of labs was below 0.1%.

For example, Milton Keynes' FPR for the ONS Infection Survey was less than 0.04% in July.

ons.gov.uk/peoplepopulati… Image
In fact, when prevalence was low, labs all over the world had less than 0.1% of tests give a positive result.

So their FPR (the % of people they tested who didn't have the virus but got a positive result) must also have been less than 0.1% at the time.

So there's nothing fundamentally wrong with PCR. It doesn't conjure up lots of false positives out of thin air when nobody has the virus.

Any false positives would mostly come from cross contamination or errors, either when the sample is taken or at the lab when it's processed. Image
Read 27 tweets
26 Dec 20
This week's Test & Trace report covers the week to December 16th, when cases in London and the South East were surging and falls in the North and Midlands levelling off.

There were also issues in the Lighthouse Lab system, apparently caused by a shortage of reagents. Image
As demand soared, almost 2 million tests were done in a week in England, which is amazing when you consider we struggled to test a few thousand people 9 months ago.

Despite this, the number of positive results rose much faster than testing, with positivity rates climbing again. ImageImageImageImage
Breaking it down by type of test done:

The new Lateral Flow Tests are still only being used on people without symptoms, so positivity is very low but rose sharply this week.

Some (but not all) PCR tests are used on people with symptoms so have higher positivity. Over 10% again. Image
Read 19 tweets
24 Dec 20
The interim report on the Liverpool community testing trial is now out, with more complete results for the sensitivity of the tests, as well as lots of additional information and data about the trial.

h/t @angelaraffle and @scb909

liverpool.ac.uk/coronavirus/re…
Firstly, more results have been released, showing the Innova LFTs only found 40% of people who were PCR positive.

More relevantly, they missed 17.6% of people positive at Ct 20 or lower, and 45.5% at Ct 20-25.

So overall they missed a third of people with "higher viral load". Image
Interestingly though, when they went back and reassessed test results based on photos of the devices (with a third person checking if the result differed from the initial one), their performance improved significantly. Finding 83% of PCR positives at or below Ct 25. Image
Read 13 tweets
22 Dec 20
2,800 lorries are now stranded in Kent, with many drivers not even having access to basic facilities. The government appears to have done nothing to help them.
Meanwhile a Sikh charity that's more used to aiding victims of wars and natural disasters is stepping in to provide bottled water and hundreds of hot meals for stranded drivers.

The good news is France has agreed to reopen the border.

The bad news is this only applies to EU nationals and residents, and they must have had a negative PCR test within the last 72 hours.

So it may be a couple of days before things get moving.

Read 6 tweets
21 Dec 20
In case you wonder why everyone's so alarmed, daily case numbers in London, the South East and the East of England are rising VERY rapidly.

Much faster than the second wave in the North and Midlands in the autumn.

And the rest of the country seems to be edging up again now too. Image
Hospital admissions in those areas are now rising rapidly as well, with the East of England actually seeing the most new admissions when you adjust for population. Image
Both the East of England and South East have now passed the number of covid patients they had in hospitals at the peak of the first wave.

London is half way to its first wave peak and rising rapidly.

And the first wave was in the spring, when hospitals are generally quieter. Image
Read 4 tweets

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