One of the best papers I read in the last few years:
Sudhir Kumar @cathyqqtao @stvnwvr @sergeilkp & al.
reconstructed virus evolution using cancer mutation lineage tracing approach @TempleUniv
@biorxivpreprint
biorxiv.org/content/10.110…
Sudhir Kumar @cathyqqtao @stvnwvr @sergeilkp & al.
reconstructed virus evolution using cancer mutation lineage tracing approach @TempleUniv
@biorxivpreprint
biorxiv.org/content/10.110…
The authors examined #SARSCoV2 evolution and found that all sequences originate from
proCoV2, the mother genome of all #SARSCoV2 sequences.
The reference SARSCoV2 sequence from 24 December (Wuhan‐1;EPI_ISL 402123) has 3 mutations compared to proCoV2.
2/
proCoV2, the mother genome of all #SARSCoV2 sequences.
The reference SARSCoV2 sequence from 24 December (Wuhan‐1;EPI_ISL 402123) has 3 mutations compared to proCoV2.
2/
The progression from proCoV2 to Wuhan-1 via 3 successive mutations is supported by >850 intermediate genomes.
The mother genome was detected in China and USA until March 2020.
3/
The mother genome was detected in China and USA until March 2020.
3/
This study included <50 genomes sampled in 2019.
WHO latest report: China had 124 confirmed COVID patients in December 2019.
(page 5 of who.int/publications/m…)
Hope these sequences will be available to go back in time.
4/
WHO latest report: China had 124 confirmed COVID patients in December 2019.
(page 5 of who.int/publications/m…)
Hope these sequences will be available to go back in time.
4/
This novel approach can be used to reconstruct evolution of other viruses, estimate mutation rate and test for recombination.
Wonderful finding!
5/5
Wonderful finding!
5/5
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