Maybe now some people will believe when I talk about cross reactive immunity. There are many redundancies in the immune system. It takes a lot for a whole world to be taken by surprise like it happened with COVID. Which is why we don’t have a new pandemic every year.
I wrote this thread about vaccines. But it also holds true for natural infections. The dose of exposure and presence or absence of repeated exposure determines durability and robustness of the immune response.
And why I’m confident that vaccines specifically designed to combat COVID 19 will be effective in preventing serious disease against new mutant variants.

The mutations have to be severe enough to make SARS CoV-2 into a new virus altogether to reduce protection significantly.
And even then as you can see there is cross reactivity between current vaccine response and original SARS virus. So total surprise of the immune system to a variant resulting in an IFR of 0.5-1% is unlikely.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Vincent Rajkumar

Vincent Rajkumar Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @VincentRK

10 Feb
I would like to share the story of how a patient with cancer came up with the idea for a randomized trial, & how listening to him saved a lot of lives.

1/ In 2002, I had just completed a randomized trial with the notorious drug thalidomide for the cancer, multiple myeloma.
2/ Thalidomide would later be FDA approved on the basis of this trial. As a young investigator I was thrilled with the success and eager for the next exciting trial testing fancy new regimens.

But a patient with myeloma, Mike Katz, had other ideas.
3/ Mike was on national patient advocacy committees. He had battled myeloma for years and knew all of the recent advances. More importantly he attended numerous patient support group meetings and had his finger on the pulse of what myeloma patients were going through.
Read 16 tweets
7 Feb
Mutants or not. This is what is happening in the UK since the start of COVID vaccination. Vaccines work.
So while we sequence and find a particular variant is dominant, the numbers that matter are total cases and deaths. The UK is doing well with vaccination and offers a preview of what is likely to happen in the US in the next month. nytimes.com/2021/02/07/hea…
Read 5 tweets
7 Feb
Reading this WSJ headline, there is an important clarification:

SARS CoV-2 and its variants are here to stay. But if we vaccinate 80% of the population, which is totally doable, then COVID-19 the disease is NOT here to stay.

1/ wsj.com/articles/as-va…
COVID-19 the disease has brought about utter chaos & turned the world upside down because of its ability to kill 0.5 to 1% of the people it infects, put ~10% of people it infects in the hospital, & leave some with long term consequences.

This won’t happen after vaccination.

2/
A respiratory virus that can easily spread is not enough to cause this kind of life-altering chaos. We already have the flu, the regular corona viruses, the rhino viruses and such.

SARS CoV-2 was new. It was new to the immune system and our bodies were attacked by surprise.

3/
Read 12 tweets
6 Feb
Our group has posted guidance for myeloma patients on COVID vaccination. I recommend the same for 𝙖𝙡𝙡 𝙘𝙖𝙣𝙘𝙚𝙧 patients. msmart.org @MayoMyeloma @MayoCancerCare
Which vaccine? Whichever approved vaccine you are offered.
Should I worry about which day of chemo or should I hold chemo?

No. These chemo drugs work for a long time and you can never be fully free from their effect. You may lose your spot in line or keep waiting for the “perfect” opportunity. Just get the vaccine when offered.
Read 7 tweets
5 Feb
Even yesterday I heard from a close friend who lost an elderly parent to COVID. They were just hoping to get vaccinated. But it was too late.

Every delay costs lives. There were over 3500 stories like this yesterday across the country.
15,000 across the world.
The new Administration took over only 15 days ago. They have a lot to deal with in terms of decisions that were already made. I have full confidence in their approach. I hope they can turn the vaccine situation around in a month.
But it’s not up to the federal government. It’s everyone from states to local governments to hospitals that have to gear up to 24/7 vaccination. Especially if J & J is approved and we have sufficient doses to dispense. Planning has to start now.
Read 4 tweets
3 Feb
If we focus on getting as many people vaccinated as possible, and continue basic precautions till each country reaches herd immunity, COVID will be history, mutants and all.
COVID minus its ability to make people severely ill or cause deaths is nothing. Vaccines work. And that’s what they will reduce COVID to.
Every month will bring news of a new variant or mutant. But for vaccinated people the chances of getting seriously ill will be very low. Not zero. But very low. In the range of what annual influenza outbreaks are. Time will tell. But I’m optimistic.
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!