# Mechanistic therapy on Notch-3 signaling, N-acetyl-cysteine prophylaxis and treatment in pulmonary fibrosis (# sequelacovid19) and other complications. #Immunometabolic
Proteins of the Notch family are cell surface receptors that TRANSDUCE SIGNALS BETWEEN NEIGHBORING CELLS. The Notch signaling pathway is evolutionarily highly conserved, including many aspects of vascular development.
The interaction of Notch receptors with ligands leads to the cleavage of the Notch intracellular domain (NICD) which then translocates to the nucleus and activates the transcription factor CBF1 / JBP-Jkappa, regulating downstream gene expression.
Not signaling is critically involved in vascular morphogenesis and function. Four Notch isoforms (Notch1-4) have been identified that regulate various cellular processes.
Of these, # Notch3 IS ALMOST EXCLUSIVELY EXPRESSED IN THE CELLS OF THE SMOOTH VASCULAR MUSCLE (#CMLV), where it PARTICIPATES critically in VASCULAR DEVELOPMENT AND DIFFERENTIATION.
Under pathological conditions, Notch3 regulates the VSMC shift between the contractile and synthetic phenotypes.
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