Thread by @MonicaGandhi9

Helpful to understand more about the Sinopharm vaccine & UAE roll-out. 4 vaccines approved in the UAE: Sinopharm, Pfizer-BioNTech, Sputnik V and Oxford-AstraZeneca. As of Feb 20, 2021, UAE has already vaccinated 56% of its population, 2nd highest in world
gulfnews.com/special-report…

Sinopharm is an inactivated virus vaccine developed in China (but phase 3 trial elsewhere as cases too low in China). We like to look at the phase I/II trial data first which was published in Lancet. Two-dose with 4 μg vaccine 3-4 weeks apart
thelancet.com/journals/lanin…

We are now used to seeing T-cell responses being measured in the safety/immunogenicity phase but not measured in Lancet paper; neutralizing Ab titers went up with time out to measured 42 days. Pain/fever most common AEs. Next -phase 2 results in JAMA
jamanetwork.com/journals/jama/…

JAMA paper showed same findings; pain at injection site main adverse reaction. Although CD4/CD8 cells measured, not reported upon in the paper. Neutralizing antibody titers here measured with 3 injections and results shown here:

Then, phase 3 trial conducted in UAE with 31, 000 participants. Results here were given as 100% effective in preventing moderate and severe COVID-19; overall 86% efficacy rate if mild disease included; 99% seroconversion rate of neutralizing antibody (other phase 3 trials too)

This chart shows you falling cases in UAE - job market apparently improving. Nice that they have 4 vaccines approved by now.
graphics.reuters.com/world-coronavi…