Thread by @MonicaGandhi9

Some of this discussion after this article came out yesterday which shows that asymptomatic infection (transmission thereby) will reduce after vaccination reminded me how wed some are to continuing a narrative of fear. Remember how we used to say that "the clinical trials

https://twitter.com/MonicaGandhi9/status/1364067385703952386

designed to tell you if asymptomatic infection was reduced because post-vaccination regular asymptomatic screening was not done?" Well, here you have this done among HCWs after vaccination - swabbing just to make sure there is no virus in the nose & 86% of the time (these

are EXPOSED health care workers, they are around others), there was NO virus in that nose. Okay, what about the remaining 14%? Take these two papers please- tweeted details before so please read those.
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…

These two papers tell us that viral load for those that still have exposure to SARS-CoV-2 4-fold reduced in nose after vaccination because immune system goes into to halt nasal replication after vaccination. Put this with what we know about infectiousness/CT/low VL can't spread

and you have a situation where transmission from a vaccinated person is vanishingly small. We have the data now . Can wear masks after vaccination to maintain social norms until herd immunity but please think about biology after vaccination. At this point, we may want to turn

our minds away from confidence intervals and make decisions on vaccination based on principles of immunology (and what we know about diagnostic tests). Natural conclusion? Asymptomatic screening of teachers (especially PCR) after vaccination in schools not indicated given data