15 quotes from Munger at the Daily Journal Meeting...

Source:
1/

On zero-commission brokerages:

"I think you should try to make your money in this world by selling other people things that are good for them."

"If you specialize in selling gambling services and rake money off the top, I think it's a dirty way to make money"
2/

"You wouldn't want to invest in a parking lot by a courthouse for the future because an awful lot of the court proceedings are going to the internet."
3/

"When you respond to software by the RFP process it's a very difficult and demanding process and it's less profitable and less sure than what Microsoft does"
4/

"We prefer holding common stocks rather than cash with the current market conditions"
5/

On the 1999 parallels today:

"Yes, I think it must end badly but I don't know when"
6/

On SPACs:

"It's just that the investment banking profession will sell sh*t as long as sh*t will be sold"
7/

"I didn't make money buy high multiple stocks in the midst of a speculative frenzy."

"But I am more willing to hold stocks at high multiples than if interest rates were a lot higher."
8/

"Value investing is trying to get more value than you pay for when you buy a stock"

"All good investing is value investing. It's just that some people look for value in strong companies and some look for value in weak companies"
9/

"I'm way more comfortable owning 2 or 3 stocks where I have an advantage" vs. owning 100 stocks
10/

"Since I never buy any gold, I never buy Bitcoin. And I think people should do the same"

"No, we will not be following Tesla into Bitcoin"
11/

On selling:

"I think you can count on the fact that if we really like the company and the management, we will be a little too loyal."
12/

"I never owned a share of General Electric because I didn't like the culture. I wasn't surprised when it blew up"
13/

On heuristics to size people up:

"If somebody is a chronic drunk, we'll avoid them"
14/

On payment for order flow:

"Nobody should believe Robinhood's trades are free"
15/

On China:

"It's entirely possible that their system was right for them and our system is right for us."

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Ryan Reeves

Ryan Reeves Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @investing_city

10 Feb
Genomics Thread #7

Let's talk about synthetic DNA...
1/ The leader here is Twist Biosciences (TWST).

Through cutting-edge science and manufacturing, they are able to produce synthetic DNA via a silicon chip.

How is this possible?
2/ It seems like science-fiction but the company can "write" DNA instead of just reading it like a normal sequencing process.

It's called phosphoramidite chemistry.

You can read more about the details here: twistbioscience.com/blog/science/s…
Read 11 tweets
9 Feb
Genomics Thread #6

Let's talk about liquid biopsies...
1/ A liquid biopsy is usually a blood-based test that can detect cancer.

How?

By detecting either CTC (circulating tumor cells) or ctDNA (circulating tumor DNA). In some studies, ctDNA has been shown to have 100x the concentration as CTC though.
2/ So why is this important?

Well, the standard of care is tissue biopsies. Doctors lop off a piece of the potentially cancerous area (a chunk of your lung for lung cancer for instance) to verify if cancer exists.

However, tissue biopsies are inferior in a few ways...
Read 12 tweets
3 Feb
Genomics Thread #5

We've already laid the groundwork for understanding DNA, and some parts of the sequencing value chain but now let's talk about genetic testing...
1/ You can think of genetic testing companies as platforms built on top of genome sequencing companies.

Some of the players here are 23andme, Ancestry, Invitae, Fulgent and Natera.

Interestingly, 23andme might come public via SPAC soon: bizjournals.com/sanjose/news/2…
2/ Ancestry and 23andme are probably the most popular DTC genetic testing companies. You receive a test kit, swab your cheek and then you can get insights into your familial history, etc.

However, the DTC market has been more difficult than servicing health care providers.
Read 12 tweets
2 Feb
Genomics Thread #4

Today we're talking about synthetic long-read companies like 10x Genomics and Bionano Genomics...
1/ In the last thread, we discussed the differences between SRS and LRS (go back and read if you need a refresher).

SRS is owned by Illumina and they have brought costs down a crazy amount.

LRS is being pioneered by PacBio and Oxford Nanopore.
2/ But in the past 5 years, there has been a lot of innovation in synthetic long-read sequencing.

The leader here is 10x Genomics.

Broadly speaking, using 10x's Chromium system, researchers can get comparable read lengths at a lower cost than true LRS.
Read 12 tweets
29 Jan
Genomics Thread #3

Let's move onto some companies!

Up first is Pacific BioSciences...
1/ When talking about genomics, the first company that comes to mind for people is likely Illumina.

They really led the charge in short-read sequencing and played a HUGE role in decreasing the overall costs to sequence a genome.
2/ Even now, Illumina has roughly 90% market share in all DNA that has been sequenced. In other words, it's the real giant in this space.

However, the next decade looks more uncertain for Illumina because long-read sequencing is actually superior in some important ways.
Read 16 tweets
28 Jan
Genomics Thread #2

Let's talk about gene sequencing...
1/ The first genome was sequenced in 1977 by Fred Sanger of a bacteriophage.

The first human genome wasn't sequenced until 2003 after 13 years of research through the Human Genome Project.

It took $3 billion (apparently $1 for each base pair 😅)
2/ In the past two decades, the cost of sequencing DNA has declined at an astounding rate.

From $3 billion with the Human Genome Project to well under $1,000 today.
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!