Honored to present at combined medicine & surgery grand rounds @UCLAHealth today & a privilege to highlight the incredible work done by the UCLA #COVID19 front line. Also packed in a review of the evidence basis for COVID therapeutics & discussed COVID recovery.
A lot to cover, and admittedly, I haven’t been that nervous about a presentation in a long time. I’ll share some slides here, starting with a summary of #COVID19 therapeutics.
Reviewing the body of evidence is always a task, even if the last time you did it was a week ago. You’ll get >100,000 results in PubMed if you search for #COVID19. In one year, there are about as many results for COVID as there are for influenza over 30 years 😳
New manuscripts are constantly being published, so this summary might end up looking completely different a few months from now...Many studies are ongoing, on these drugs and others.
#CCCF2020 Brian Kavanaugh Controversies - #COVID19: #ARDS or not? What we really addressed - not so much "is it ARDS?" but rather, "does it matter?" So happy to have been a part of this, but man, I still have so much to say! My take on the ? – yes, it matters - to an extent 🧵 1/
Pre-intubation management: YES, but not because it substantially changes methods of support, or the criteria used for #intubation. It matters because categorizing patients as having #ARDS has value. 2/
If we use the Berlin definition, patients on Venturi masks or arguably #HFNC don’t actually meet criteria for #ARDS because they’re not on PEEP >/= 5. The natural history of ARDS though almost certainly begins prior to the use of mechanical ventilation (invasive or not). 3/