Excellent paper on the human B cell response to COVID-19, by the fantastic Laura Walker. 🧵
immunology.sciencemag.org/content/6/56/e…
immunology.sciencemag.org/content/6/56/e…
1,213 human monoclonal antibodies (!), showing substantial affinity maturation of the B cells over time.
A substantial fraction of the Spike-specific response is to RBD. Consistent with other work. 
In their hands, virtually all of the potent neutralizing antibodies target RBD.
While common cold coronavirus crossreactive memory B cells participated in the immune response to SARS-CoV-2, none of them were neutralizing.
That is consistent with excellent work in this complimentary paper, which saw a bimodal distribution in early SHM in non-RBD Spike-specific B cells but not RBD-specific, indicative of memory B cells to previous betacoronavirus infections.
doi.org/10.1016/j.cell…
doi.org/10.1016/j.cell…
Overall, beautiful work by Walker, and a lot of consistent findings now in the literature on SARS-CoV-2 memory B cell responses.
• • •
Missing some Tweet in this thread? You can try to
force a refresh
