CDC's ACIP now talking about what data would be needed to inform delaying the 2nd dose of mRNA vaccines or single dose of mRNA vaccine for individuals w/ prioir confirmed SARs-coV-2 infection.
Sanchez - said have to go with what the RCTs showed us for timing of 2nd dose.
for single dose for peope w/ past infection -- he thinks need more data but could see this being a possibility down the line.
for single dose for peope w/ past infection -- he thinks need more data but could see this being a possibility down the line.
Talbot - says we don't need more data re single-dose of mRNA for people w/ confirmed infection - seems to think we could pivot now.
Long - suggesting second vaccine dose for people w/ prioir infection might actually be more harmful than helpful.
But Chair Romero - notes not everyone with past infection may have high enough levels of antiibody or other immune responses -- need to know more about longetivy of proection.
we need more data about correlates of protection and duration of immunity and how current mRNA vaccines fit with variants. I’m not so enthusiastic about going w/ single dose in those with prior confirmed infection.
Cotton - says immunocomprmised people may need 2 doses regardless - this could make guidelines challenging if people w/ past infection in general only need 1 dose.
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