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Sarah Karlin-Smith

1 Mar, 5 tweets, 1 min read

I'm watching the second day of CDC's ACIP meeting today. This meeting if focused more broadly on COVID-19 vaccines than yesterday's.

ACIP going to discuss possibility of delaying 2nd dose of mRNA vaccines as well as whether people who already had COVID-19 only need 1 dose. $BNTX $PFE $MRNA

CDC's Dooling says in Phase I/2 trials neutralizing antibodies did not show large increases until after 2nd dose of mRNA vaccines.

cdc's dooling - majority fo workgroup felt insufficent data to increase recommended intervals beteen mRNA vaccines.

and the work group also thinks there is insufficent data to support changes to guidance and recommendations in regards to suggesting that people w/ prior covid-19 could just get one dose of the mRNA vaccines. recommend sticking with two-doses. #COVID-19 #vaccine

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Sarah Karlin-Smith

@SarahKarlin

1 Mar

CDC's ACIP now talking about what data would be needed to inform delaying the 2nd dose of mRNA vaccines or single dose of mRNA vaccine for individuals w/ prioir confirmed SARs-coV-2 infection.

Sanchez - said have to go with what the RCTs showed us for timing of 2nd dose.

for single dose for peope w/ past infection -- he thinks need more data but could see this being a possibility down the line.

Talbot - says we don't need more data re single-dose of mRNA for people w/ confirmed infection - seems to think we could pivot now.

Read 7 tweets

Sarah Karlin-Smith

@SarahKarlin

5 Feb

@NateSilver538

screams into the abyss becuase people just don't get it!!!

.@NateSilver538 please please please please please call some people who understand the FDA and vaccine review.

https://twitter.com/NateSilver538/status/1357493589031452679

@NateSilver538

@NateSilver538 1. the US needs to stop pretending that vaccines are our ONLY tool. There are many and we need to do a lot better job using the other ones while the vaccine deveolpment does its thing.

@NateSilver538

@NateSilver538 2. I don't think people appreciate how much data FDA is going to pour through and how understaffed and overworked they are.

again read @KatherineEban's piece which will break your heart about the toll this pandemic has taken on some of its reviewers.

Read 7 tweets

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