Some good news for your day! The latest real-world study from Public Health England (PHE) shows that both Pfizer’s AND Oxford-AstraZeneca’s vaccines are both highly effective in reducing SARS-CoV-2 infections among older people aged 70 years and over.
khub.net/documents/1359…
Since January, protection against symptomatic COVID, 4 weeks after the first dose, ranged between 57 and 61% for one dose of Pfizer’s vaccine and between 60 and 73% for Oxford-AstraZeneca’s vaccine. Their data shows symptomatic infections in those over 70 decreasing from around 3
weeks after one dose of either vaccine. In those over 80, study data suggested a single dose of either vaccine is more than 80% effective at preventing hospitalization, around 3 to 4 weeks post immunization. Evidence also suggests Pfizer’s vaccine, leads to an 83% reduction in
deaths from COVID-19. Make no mistake these studies continue to provide further evidence these vaccines are working and are highly effective in protecting us against severe disease, hospitalization, and death.
And if you want some more data on the effectiveness of these vaccines from a previous PHE study on reduction of asymptomatic cases (because this study deserves much more attention) please see:
For those who were asking. It was announced that those who are over 65 in France will be able to receive Oxford/AstraZeneca vaccine after all in a change to an original decision which was because of lack of insufficient data for that age group. The good results are catching on.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Mac n’ Chise 🧬🦠🧫

Mac n’ Chise 🧬🦠🧫 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @sailorrooscout

3 Mar
I thought it was vital to bring this up as I am seeing this study circulate and being used in a lot of media today concerning Brazil’s variant P.1. Most of the misinformation over Brazil’s variant P.1 appears to stem from a single, unreliable serological survey in Manaus. 🧵
We can see the media has latched on to a study which claimed Manaus had reached herd immunity due to 76% of its population being previously infected with SARS-CoV-2. The claim was based on flawed serology data- its likely they never did. We now see that any reference to Manaus is
laced with fear of reinfection, despite there being no evidence of this on a larger scale. A follow-up study that received less publicity found that their peak was more like 15% rather than 76% that was being circulated and claimed.
thelancet.com/journals/langl…
Read 11 tweets
3 Mar
A recent study shows Pfizer’s and Moderna’s vaccines are protective against SARS-CoV-2 variant P.1. Despite some reduction, loss of neutralizing activity was modest (2.8 & 2.2 fold) & reduction was not as striking as observed prior against B.1.351. 🧵
biorxiv.org/content/10.110…
To study this, researchers created a VSV-based SARS-CoV-2 pseudovirus with all 10 mutations of the P.1 variant (B.1.1.28 lineage) and assessed its susceptibility to neutralization by neutralizing mAbs, convalescent plasma of patients, and vaccinee sera.
For thoroughness, activity of four mAbs including REGN10987 (imdevimab), REGN10933 (casirivimab), LY-CoV555 (bamlanivimab) and CB6 (etesevimab), six NTD mAbs, convalescent plasma of patients infected in Spring of 2020, and sera of Moderna and Pfizer recipients were analyzed.
Read 9 tweets
3 Mar
Cell-mediated immunity at work! Researchers in South Africa have found it you were previously infected with 501Y.V2 (B.1.351) your antibodies are cross-reactive and thereby able to neutralize other variants of SARS-CoV-2 and prevent infection from other variants! Image
Their research demonstrates immune response to B.1.351 is as potent as that seen in those infected with the original variant. Furthermore, antibodies from people infected with B.1.351 are not only able to neutralize B.1.351 but variant P.1 as well!
The press conference can be found here:
Read 7 tweets
2 Mar
The importance of T-cell immunity! This study finds CD4+ and CD8+ T-cell mediated responses are minimally affected by mutations found in SARS-CoV-2 VOCs (B.1.1.7, B.1.351, & P.1.) and VOI CAL20.C! Immunity is about more than just antibodies! Let’s go! 🧵
biorxiv.org/content/10.110…
Researchers utilized convalescent plasma to directly assess TCRs from persons recovered from previous SARS-CoV-2 infections obtained before the emergence of the variants, and from recent Moderna and Pfizer vaccine recipients for their capacity to recognize peptides derived from
the ancestral reference sequence as well as the B.1.1.7, B1.351, P.1 and the CAL.20C variants. Bioinformatic analyses were utilized to predict the impact of mutations in the various variants with sets of previously reported CD4+ and CD8+ T cell epitopes derived from the ancestral
Read 14 tweets
28 Feb
Guys. This is P.1. It isn’t “new” or “novel.” It has now been detected in cases in the U.K. We know the vaccines can neutralize this variant, and updated boosters should they be needed are already in development. Please don’t be alarmed. This is what viruses do, they spread.
If you’re interested in reading more about mutations and how we go about controlling these please see:
Keep in mind this study only takes into account humoral immunity and nAbs rather than cell mediated immunity as well (which I am a huge advocate for) but you can see the vaccines can neutralize P.1.
medrxiv.org/content/10.110…
Read 10 tweets
26 Feb
Ready for some wonderful news? Here we go! A recent study has found that a single dose of Pfizer’s vaccine can reduce the number of asymptomatic SARS-CoV-2 infections by 75%. This demonstrates these vaccines can greatly reduce the risk of transmission. 🧵
authorea.com/users/332778/a…
Cambridge University Hospitals NHS Foundation Trust and researchers at the University of Cambridge analyzed their results from thousands of COVID-19 tests carried out each week as part of their screening program on asymptomatic HCWs who showed no signs of infection.
Their vaccination program for HCWs began on December 8th of last year, with mass vaccination efforts continuing til January 8th of this year. During a two-week period between the 18th and 31st of January, researchers screened similar numbers of vaccinated and unvaccinated staff.
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!