We are all scratching our heads at some of things being announced by Gov. We have the Variants, all originating ('put in place' according to Hancock?) where an AZ trial has been - South Africa, Brazil, Bristol. Remarkably Brazil seems to have heard nothing about their variant.
The Bristol Trial is not listed on here. clinicaltrials.gov/ct2/results?te… It also doesn't seem to be listed on here. astrazenecagrouptrials.pharmacm.com/ST/Submission/… BUT news about it is listed here on the Oxford Vaccine Group Website, which has a rather nauseating CGI of a moving Green viral monster.
The results of Phase I/II trial that took place in London, BRISTOL, Southampton and Oxford are shown here in summary in the Lancet (a favourite life sciences publication - remember H@Q?) thelancet.com/journals/lance…. Wondering if there are variants for London, Southampton and Oxford?
Phase II/III, which many people seem to think is over and results are out already, is still ongoing. See the different sites here covid19vaccinetrial.co.uk/participate-tr…. The interim analysis of results was published in the Lancet in December 2020 thelancet.com/journals/lance….
Funders for the Phase II/III are listed in the Lancet below. Interestingly included in Phase III are studies taking place in the US, and completes in 2023 clinicaltrials.gov/ct2/show/NCT04… and also again in Brazil, South Africa and now Kenya (KEMRI at Kilifi - keep an eye on that one) 
We heard Matt Hancock in his presser on the 1st March say that we do not have efficacy data on the second jab for Astra Zeneca. So what exactly have they been doing in these trials? According to Oxford they DO have efficacy data on the two jabs 'Phase 3 interim analysis...
...including 131 Covid-19 cases indicates that the vaccine is 70.4% effective when combining data from two dosing regimens'. research.ox.ac.uk/Article/2020-1…. Very puzzling. Or is that because it is interim data rather than final data?
That brings me on to Efficacy variations over time. We have ibtimes.com/which-covid-19… quoting AZ is 60% effective (presuming 2 doses), 70.4% effective by Oxford Vaccine Group, 76% effective for 3 months after a single dose, cnbc.com/2021/02/03/del…
64.1% after a single dose for AZ bbc.com/future/article… and bizarrely 90% effective after 1st 1/2 dose and full 2nd dose?? Last night, Matt Hancock says the first dose is now somehow 80% effective. Confusing for everyone.
WHY are 2nd doses been delayed for 9 weeks. It is miraculous that our 2nd jabs are timed for when our Brazil infected individual has escaped detection. Priming for a new phase of illness? Incentive to turn up for 2nd appointment? Cover for something else?
Two tweets down for the Oxford Vaccine group link
• • •
Missing some Tweet in this thread? You can try to
force a refresh
