Check out the latest experimental work from our group.biorxiv.org/content/10.110…; Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.@atarke @Alba_Grifoni @profshanecrotty @Dani6020.
1-CD4 and CD8 T cells induced by the ancestral reference sequence recognize the four common SARS-CoV2 variants B.1.1.7, B.1.153, P.1. and CAL.20C.
2-We think this is really good news. This is true for both COVID survivors and people who received the Moderna and Pfizer vaccines.
3-No substantial reduction observed regardless of the antigens considered, either S for vaccinees, or full genome for COVID survivors.
4-We also show that the vast majority of epitopes recognized by COVID survivors described in sciencedirect.com/science/articl… unchanged in all four variants.
5-The data provide some positive news in light of justified concern over the impact of SARS-CoV-2 variants of concern on efforts to control and eliminate the present pandemic.
6-While it is not anticipated that circulating memory T cells would prevent infection, they could reduce COVID-19 severity.
7- Early SARS-CoV-2 T cell responses are associated with milder COVID-19 (Rydyznski Moderbacher et al., 2020; Tan et al., 2021).
8-Thus, the T cell response may contribute to limiting COVID-19 severity induced by variants that partially or largely escape neutralizing antibodies.
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