Short thread:

When things work well, they are unnoticeable to the public.

This is especially true of public health efforts. When public health efforts work, they go unnoticed. As in policy, boring is better in public health.

1/x

theatlantic.com/ideas/archive/…
Unfortunately, this fact, that when public health is working well, it is unnoticed, necessarily sets them up to appear like they are failing.

The only time the public thinks about successful public health efforts is when they falter at all, especially if faltering is rare.

2/x
This happens all the time with the most successful vaccines... b/c the only time highly successful vaccines make the news (outside of a pandemic) is when a rare adverse event occurs. We simply don't report the constant daily successes of the best working programs.

3/x
The same thing with testing programs to prevent outbreaks.

If a testing program prevents 99% of outbreaks - these will NOT be discussed in the media.

But the 1% of the time that a small outbreak occurs, it is discussed... causing a false denominator in the publics mind...

4/x
We saw this with the WH RoseGarden event.

Although the WH prevented any outbreaks for over 200 days... the only time outbreaks inside the WH were discussed was when an outbreak did happen - but not all of the days an outbreak did not happen....

5/x
This ultimately caused the public to conclude that a rapid testing "entrance screening" program in the WH was a total and complete failure. To this day it is held up as evidence that rapid tests don't work.

But in reality it failed <1% of the days & succeeded >99% of days

6/x
This is a perpetual problem of public health - the better it works, the more scrutiny is placed on rare negative events.

This begs for the media to TRY to report on at least some successes

(Sometimes successes are widely reported - largely owing to positive trials)

7/x
So when we see headlines or fingers pointing to an event as evidence that a whole program doesn't work... try to ask the question - "How many times is it working but I'm just not noticing".

Obviously we should be using this thought process in so many parts of life too...

8/8

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More from @michaelmina_lab

28 Feb
Interesting fact

I’ve not been PCR tested-Yet I helped start what is now the highest (?) throughput PCR lab in the world

Wouldn’t know where to sign up / don’t have time to stand in line for a test w results days later

I do have access to simple rapid at-home tests, 2x/wk

1/x
I’m not special. If I don’t have time to stand in line, millions and millions of others do not have time to do this.

If I’m not readily aware of how to sign up - millions of others aren’t. Sure, Google will tell me, but not everyone can just figure it out.

2/x
Testing is simply not equitable in the US and access is limited

Nearly 65% of Americans have never been tested. Not bc they don’t want to, but bc it’s not simple. Testing is a public good - we must make it simple!

At-home tests will improve equity and our public health response
Read 4 tweets
26 Feb
THREAD: NEW INFORMATION!

A first of its kind national survey out today from @CCDD_HSPH @TheCOVIDCollab and @HartSurveys on at-home rapid testing

What did we learn?

86% of Americans are willing/eager to use at-home rapid tests – BUT awareness of rapid antigen tests is low

1/x
This week Congress is considering $46B for testing, including for rapid tests. What does America think about that?

85% of Americans want government to fund these tests & distribute them. Strong support for rapid tests across political spectrum: 94% of Dems and 74% of Repubs.
But support for testing doesn’t come at any price. Willingness to test at-home decreases as $ increases. At $25 (price of the only two currently EUA authorized rapid at-home tests), only 33% of Americans would test themselves regularly.
Read 11 tweets
18 Feb
On TTI as a control measure:

Early 2020, we said contact tracing would not control community spread against #COVID19 once cases got high

Yet when cases got high, it was blasphemy to suggest lab PCR+contact tracing not useful to control spread.

Data is now catching up.

1/
The tweet thread above by Denis Nash @epi_dude is terrific and contains lots of wonderful data!

For me, It highlights the need for us to re-evaluate what it is we are doing. When our actions weren't working to slow spread, should we have kept forcing the same actions?

2/x
I worry that we get into group-think mentality and peer pressure is immense to "stick with the consensus"...

but when consensus is to stick to a failing test-trace-isolate as control, against our own warnings to our future selves... maybe we should've bucked the trend?

3/x
Read 8 tweets
13 Feb
NEW RESEARCH

Knowing if #COVID19 cases are going up v down is needed for decision making but changes in testing make it difficult to know

We found Instead of case counts, the distribution of Ct values gives a NEW way to estimate epidemic trajectory!

1/

medrxiv.org/content/10.110…
Essentially, we created a barometer that gives the growth rate (or decay rate) of an epidemic based entirely on whether the distribution of viral loads in ppl at a single time in a population is averaging high (epidemic growing) or low (epidemic declining).

2/x
This property of epidemics (when they are going up, detected virus loads are higher on average) has caused massive confusion.

The virus itself isn’t changing nor are the actual virus loads inside of individual people...

3/x
Read 9 tweets
10 Feb
Terrific write up!

Perhaps the most thorough reporting I’ve seen on the controversies surrounding rapid tests

An extremely important point @GiorgiaWithAnI covered is one at heart of the confusion but previously not covered well..

See short thread

1/x

nature.com/articles/d4158…
I’ve spoken on sensitivity and why rapid Ag tests shouldn’t be compared to PCR

Nevertheless, we’re stuck comparing to PCR. So, to deal w this, “we” have taken to comparing rapid antigen tests to PCR results below specific Ct values that may represent contagious virus loads

2/x
In many studies, Ct of <30 or <25 are considered to be likely contagious or “high virus”, respectively

HOWEVER this is bad. We must stop assuming this

Not all labs are the same

A Ct 25 in many labs may = a Ct of 18 elsewhere

This happened in Liverpool w Innova evaluation

3/x
Read 7 tweets
8 Feb
The new variant B.1.351 is evading immunity, infecting ppl already vaccinated w AZ vaccine

I’m concerned for the others too since all have very similar design against original Spike

This should be a wake up call

#Rapidtests needed for contingency plans

nytimes.com/2021/02/07/wor…
Good thing is the mRNA vaccines provided exceptional efficacy. But that was also when plasmablasts (temporary antibody producing cells) were fully abundant. We don’t know the efficacy after a few months after they all die off. Hopefully will remain very high and protect. But..???
We also do not know (or at least so far I haven’t heard) whether people are getting severely ill or not. If the AZ vaccine prevents severe disease w the new variant, then that can be good enough. I wish this part was reported so far.
Read 5 tweets

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