Thread by @ProfTimNoakes

He's so right. If you have to obsess over something, obsess over insulin resistance, metabolic syndrome, T2DM. Rest is pretty irrelevant. Latest study from the Women's Health Initiative reported in JAMA in January FINALLY proves this jamanetwork.com/journals/jamac…

https://twitter.com/thrill_tweeter/status/1369239024339140608

Study's SO IMPORTANT because it comes from Women's Health Initiative which began in 1993 with specific goal of proving that low-fat "heart-healthy" US Dietary Guidelines will prevent T2DM, CHD, cancer, obesity etc. So authors' bias would always be to find in favour of that diet

So what did the study find?
T2DM increased risk of developing CHD 10-FOLD; metabolic syndrome 6-fold; hypertension 5-fold; obesity 4-fold! The best biomarker was lipoprotein insulin resistance at 6.4 fold increased risk. Nothing else came close. But what of LDL-Cholesterol?

Well LDL-cholesterol was associated with a 1.4 fold increased (associational) risk which is meaningless.

So in summary: The much vaunted $700 million Women's Health Initiative - a key component of which was to prove we should all be eating a low-fat "heart-healthy" diet - has now provided the ultimate disproof of that hypothesis. Nina Teicholz @bigfatsurprise was right all along.

So too was Dr Robert Atkins MD. This study shows that if you want to prevent CHD, you must prevent T2DM, Metabolic Syndrome and hypertension- all features of insulin resistance.
@virtahealth study (and others) shows most effective way to do that is to eat LCHF diet of real foods