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Thanks @J_Imagineering So here’s my argument.
1. Humans eating rapidly assimilated carbohydrates develop post-prandial hyperglycemia in proportion to the rate at which glucose is absorbed from the intestine bit.ly/1ExzbZs (primate study noted).
1. Humans eating rapidly assimilated carbohydrates develop post-prandial hyperglycemia in proportion to the rate at which glucose is absorbed from the intestine bit.ly/1ExzbZs (primate study noted).
2. Is there any evidence that postprandial hyperglycemia is good and serves an evolutionarily valuable function? Answer: Probably not. Supporting evidence: Why do human have a total circulating blood glucose mass of only 5 grams?
3. If post-prandial hyperglycemia is not desirable (in fact, probably harmful – see problems in T2DM) and has no evolutionary value, then why does it happen?
4. Post-prandial hyperglycemia happens because the human response to glucose arriving from the portal vein into the liver does not completely inhibit endogenous liver glucose production (again data from primate model) bit.ly/1ExzbZs
5. As result blood glucose concentrations rise as there’s only partial (not complete) inhibition of endogenous liver glucose production. In contrast complete inhibition of endogenous liver glucose production would prevent any post-prandial hyperglycemia.
6. Which raises the question: Are humans unique in showing repetitive (every few hours) post-prandial hyperglycemia (because they are now eating a diet that is high in sucrose/HFCS and in rapidly assimilated carbohydrates) - different from the primates/pre-humans in our lineage?
7. Answer is: I don’t know. But only published study I could find shows essentially FLAT 24-hr blood glucose levels (see Figures 2 and 3; page 971) in monkeys eating standard diet including some fruit and vegetables bit.ly/2RxIJPg We'd conclude: Perfect glucose control!
8. But bananas causes marked hyperglycemia bit.ly/2RxKc8e So bananas are used for glucose tolerance testing in monkeys.
9. So my suggestion is: If you believe that post-prandial hyperglycaemia (with associated hyperinsulinemia) is a normal and safe feature of human physiology that has evolutionary value, then don't concern yourself about the amount of sugar/HFCS and carbs you are eating.
10. If on other hand like me you're IR/T2DM (of if you don't know if you're IR/T2DM), you might want to consider whether you should be limiting frequency and extent of post-prandial hyperglycemic/hyperinsulinemic bouts to which you are exposing your body on a daily (hourly) basis
