I am not terribly excited about the "clot" concerns for AZ/Ox in Europe:
medscape.com/viewarticle/94…
Both because it's not in the US, and I didn't like their data or how they collected it very much;
and because I am not sure this is a story. 1/3
I mean, if the avg vaccinated pop would have about a 1/6000 risk per mo of a VTE as the background rate;
and 5M ppl got the AZ/Ox in the past mo;
we'd expect >800 VTEs in any circumstance, not 30! 2/3
Maybe the up side of this latest issue w/ the ill-fated AZ/Ox vaccine is for all the Vax-suspicious out there:
living proof that Big Pharma, Big Govt,etc isn't doing a very good job of "covering up" adverse events.
Arguably, they're swinging too far to the other extreme here! 3/3
I feel fully vindicated in my assessment today since it has been independently verified by a completely trustable source:
*an AstraZeneca press release*.
OK, sketchy - but I still think they're right.
Overall, it shows that signals for adverse effects are being taken seriously.

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More from @buzzhollandermd

14 Mar
Another look at long covid out in a pre-print, from @mlipsitch&co:
medrxiv.org/content/10.110…
I'm not surprised, but at last someone had the notion to compare folks post-covid to folks post-viral-infection, non-covid.
The headline is "14% had sequelae" but they buried the lede! 1/6 Image
First, the limitations:
1) totally based, not on survey/exam, but on MD-reported ICD-10 codes; so these are "long," possibly random, symptoms bad enough to see an MD and have them code it.
2) retrospective cohort, so all the usual bias & matching concerns.
3) only age 18-65. 2/6
But it was HUGE (>200K matched cases), which helps;
and fairly well-matched;
and, at last, well-chosen cohorts (2020 no covid, 2019, pre-2020 viral).
WHAT DID THEY FIND???
Post-covid, you had a 14.6% chance of seeing an MD for post-viral problems.
Pre-2020 virus? 13%. 3/6 Image
Read 6 tweets
12 Mar
I missed this disturbing/fascinating bit on leaked docs w/ quality control issues from the Pfizer vaccine:
bmj.com/content/372/bm…
A reminder that just because Big Pharma hits a home run, they (& the medical-industrial complex) are not suddenly warm and fuzzy trusted friends. 1/3
I wish I understood mRNA vaccines better, but the bottom line appears to be:
these mRNA particles tucked in those lipid nanoparticle membranes are frail;
they degrade easily;
and you want them to be intact when they hit our cells, so the proper protein complexes are formed. 2/3
Since "commercial grade" seems to be 75-80% intact mRNA, and the "bad" batches were around 55%, that would imply about a third less production of proper spike-like proteins.
Not from zero to something, but from 25% to 45%.
So - I doubt these are forming *dangerous* proteins. Image
Read 4 tweets
20 Dec 20
A few patients have asked me to look into the research on ivermectin for Covid-19.
You know, that video of congressional testimony and all, from that Pulmonologist.
IVERMECTIN SOUNDS FABULOUS! 1/20

Now, when I see a gray-haired, highly-confident, white dude speaking strongly on a matter outside his own field of expertise, I get this comfortable feeling:
"That is MY demographic!"
But when he goes on about his own credentials;
and calls a re-purposed med "miraculous"... 2/20
I get that skeptical feeling.
But - I'll try to put that aside, and just look at their data.
It's a lot to review.
These folks, the FRONT LINE COVID-19 CRITICAL CARE ALLIANCE, put out a 33 pg document summarizing the research on ivermectin and covid. 3/20

covid19criticalcare.com/wp-content/upl…
Read 23 tweets

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