In May 2020, we would have been happy with any vaccine by 2022
By fall 2020, we were going to be happy if any vaccine was 50% effective.
By Feb 2021, we have vaccines with 95% efficacy but we worry about why it's not 100% effective, & if it prevents transmission or long COVID.
What we can control: Try and vaccinate as many people as possible, globally, so that there are less immunologically unprepared hosts for the virus to multiply in.
What we cannot control: The innate ability of the virus to mutate.
What we can do: Take precautions till a significant proportion of the population you live in has been vaccinated.
What we can't do: Create new vaccines in a month. It's going to take time for boosters that improve on the protection offered by current vaccines to arrive.
I called it a blunder then.
Why because it didn't make sense as the right judgment call.
We were essentially saying no to a vaccine when we we had 200,000 new daily cases a day and 3000 new deaths a day.
Too many pundits criticized the initial Astra Zeneca trials. Overstating procedural problems double blind placebo controlled trials. Most of these pundits were purists who had never led a randomized trial themselves. Let alone in lightning speed.
5/ The rate of DIC and cerebral venous thrombosis appear higher than expected baseline.
6/ Since these adverse events are very rare, the risks of COVID high, & the high efficacy of the vaccine, the @EMA_News recommended that the benefits of the vaccine outweighed the risks.
1/ Change in diagnostic criteria. MDE not CRAB. @TheLancetOncol
2/ Treatment of high risk SMM. Early preventive therapy with Len or Len/dex significantly delays end organ damage in high risk SMM. @SagarLonialMD@mvmateos
3/ Role of Transplant.
Early versus Delayed Transplant. Similar overall survival at 8 years means selected patients with standard risk myeloma can opt to delay transplant if feasible.
>2000 COVID deaths a day in the EU. Lots more seriously ill. Astra Zeneca vaccine (& all other approved vaccines) are 100% effective in preventing hospitalization & deaths.
The potential risk reported is a rare form of blood clots in 11 out of 17 million vaccinated.
This is how good the vaccines are in preventing this worst pandemic of all time. 👇👇